Results 311 to 320 of about 980,977 (401)

Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation

Arthritis &Rheumatology, Accepted Article.
Background Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Since mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong, Yanhua Xiao, Haodong Qi, Shihao Zhu, Tim Filla, Andrea‐Hermina Györfi, Yi‐Nan Li, Meilin Xu, Langxian Zhi, Thuong Trinh‐Minh, Clara Dees, Georg Schett, Jörg H.W. Distler, Alexandru‐Emil Matei   +13 more
wiley   +1 more source

Intrinsic mechanotransduction during apical constriction licenses lineage competence in pluripotent stem cells

Hamouda MS, Labouesse C, Wylde GW, Yamamoto D, Miroshnikova YA, Basu S, Clare WM, Chalut KJ.   +7 more
europepmc   +1 more source

Generation of Induced Pluripotent Stem Cells and Neuroepithelial Stem Cells from a Family with the Pathogenic Variant p.Q337X in Progranulin. [PDF]

Int J Mol Sci
Gaweda-Walerych K, Figarski A, Gawlik-Zawiślak S, Woźniak M, Chołoniewska A, Mierzwa N, Lutostańska E, Szymanowski J, Wężyk M.   +8 more
europepmc   +1 more source

Hydrogel Embedding of Mesenchymal Stem Cells Supports Extracellular Vesicle Production

Biotechnology and Bioengineering, EarlyView.
This study investigates the effects of 3D culture conditions on extracellular vesicle (EV) production by mesenchymal stem cells (MSCs) in a gelatin‐based hydrogel matrix (GelMA). The EVs from both conditions were found to have similar morphological, molecular, and functional properties, but 3D cultures produced more total EVs per volume.
Rachel K. Moen, Gabriella Faircloth, Nicole T. Marguerite, Mariachiara Conti, Ethan S. Lippmann, Jamey D. Young   +5 more
wiley   +1 more source

Upscaling: efficient generation of human lung organoids from induced pluripotent stem cells using a stirring bioreactor. [PDF]

Front Bioeng Biotechnol
Budeus B, Kroepel C, Sevindik ZF, Buttler LF, Klein D.   +4 more
europepmc   +1 more source

Combination of Atelocollagen Gel With Induced Pluripotent Stem Cell-Derived Tenocyte for Rotator Cuff Tendon Regeneration in a Rat Model

Jong-Ho Kim, Darryl D. DʼLima, Yang-Soo Kim, Jong-Ick Kim, Hyojin Lee   +4 more
openalex   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source

NGR1 Pretreatment Enhances the Therapeutic Efficacy of Transplanting Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells for Myocardial Infarction. [PDF]

Int J Mol Sci
Cai H, Huang MY, Mou FF, Wang QL, Luo ZR, Lu PP, Liu BN, Hu L, Guo HD.   +8 more
europepmc   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Recombinant production of canine vitronectin for optimizing the culture of canine induced pluripotent stem cells. [PDF]

Regen Ther
Shishida K, Ikuta Y, Sugisaki H, Kimura K, Katahira J, Tsukamoto M, Hatoya S.   +6 more
europepmc   +1 more source