Results 31 to 40 of about 201,548 (273)

DIRECTED RE-PROGRAMMING OF SOMATIC CELLS: ADVANTAGES AND LIMITATIONS OF INDUCED PLURIPOTENT STEM CELLS (REVIEW)

Сибирский научный медицинский журнал, 2019
Stem cells are divided into embryonic and adult stem cells. The relevance of the use of stem cells in clinical practice has received new evidence in recent years however, the methods of obtaining stem cells for medical purposes cause ethical rejection ...
A. V. Korel, S. B. Kuznetsov
doaj   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Non-coding microRNAs for cardiac regeneration: Exploring novel alternatives to induce heart healing

Non-coding RNA Research, 2017
In recent years, different studies have revealed that adult mammalian cardiomyocytes have the capacity to self-renew under homeostatic conditions and after myocardial injury.
Elena Garreta, Patricia Prado, Juan Carlos Izpisua Belmonte, Nuria Montserrat   +3 more
doaj  

Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff

Stem Cell Research, 2017
The diverse cell states and in vitro conditions for the derivation and maintenance of the mammalian embryo-derived pluripotent stem cells raise the questions of whether there are multiple states of pluripotency of the stem cells of each species, and if ...
Pierre Savatier, Pierre Osteil, Patrick P.L. Tam   +2 more
doaj   +1 more source

Cellular network entropy as the energy potential in Waddington's differentiation landscape [PDF]

Scientific Reports (2013) 3, 3039, 2013
Differentiation is a key cellular process in normal tissue development that is significantly altered in cancer. Although molecular signatures characterising pluripotency and multipotency exist, there is, as yet, no single quantitative mark of a cellular sample's position in the global differentiation hierarchy. Here we adopt a systems view and consider
arxiv   +1 more source

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

Glucokinase (GCK) in diabetes: from molecular mechanisms to disease pathogenesis

Cellular & Molecular Biology Letters
Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver.
Yasmin Abu Aqel, Aldana Alnesf, Idil I. Aigha, Zeyaul Islam, Prasanna R. Kolatkar, Adrian Teo, Essam M. Abdelalim   +6 more
doaj   +1 more source

Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media

Regenerative Therapy, 2017
Human pluripotent stem cells are considered to be ideal cell sources for regenerative medicine, but their clinical and industrial application is hindered by their tumorigenic potential.
Hiroaki Tateno, Keiko Hiemori, Kazunari Hirayasu, Nagako Sougawa, Masakazu Fukuda, Masaki Warashina, Makoto Amano, Taku Funakoshi, Yoshifusa Sadamura, Shigeru Miyagawa, Atsuhiro Saito, Yoshiki Sawa, Tomoko Shofuda, Miho Sumida, Yonehiro Kanemura, Masaya Nakamura, Hideyuki Okano, Yasuko Onuma, Yuzuru Ito, Makoto Asashima, Jun Hirabayashi   +20 more
doaj   +1 more source

Unleashing the Power of Multiomics: Unraveling the Molecular Landscape of Peripheral Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Peripheral neuropathies (PNs) affect over 20 million individuals in the United States, manifesting as a wide range of sensory, motor, and autonomic nerve symptoms. While various conditions such as diabetes, metabolic disorders, trauma, autoimmune disease, and chemotherapy‐induced neurotoxicity have been linked to PN, approximately one‐third of
Julie Choi, Zitian Tang, Wendy Dong, Jenna Ulibarri, Elvisa Mehinovic, Simone Thomas, Ahmet Höke, Sheng Chih Jin   +7 more
wiley   +1 more source

Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development

Scientific Reports
Thyroid hormones (TH) play critical roles during nervous system development and patients carrying coding variants of MCT8 (monocarboxylate transporter 8) or THRA (thyroid hormone receptor alpha) present a spectrum of neurological phenotypes resulting ...
Adina Sophie Graffunder, Audrey Amber Julie Bresser, Valeria Fernandez Vallone, Matthias Megges, Harald Stachelscheid, Peter Kühnen, Robert Opitz   +6 more
doaj   +1 more source