Results 41 to 50 of about 980,977 (401)

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

eLife, 2020
Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell fate decisions during pre-implantation development, but their lineage potential remains incompletely characterized.
C. Dong, Mariana Beltcheva, P. Gontarz, Bo Zhang, Pooja Popli, Laura A. Fischer, S. Khan, Kyoung-mi Park, Eun-Ja Yoon, X. Xing, R. Kommagani, Ting Wang, L. Solnica-Krezel, T. Theunissen   +13 more
semanticscholar   +1 more source

Generation of human induced pluripotent stem cell line from an obesity patient with POMC deficiency due to POMC:W84X mutation

Stem Cell Research
We generated the human induced pluripotent stem cell (iPSC) line BIHi261-A from dermal fibroblasts of a patient with severe early-onset obesity caused by a homozygous truncating mutation in the POMC gene (W84X).
Katarzyna A. Ludwik, Regina Jahn, Sabine Jyrch, Lara Lechner, Valeria Fernandez Valone, Peter Kühnen, Harald Stachelscheid   +6 more
doaj   +1 more source

Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) are adult stem cells with fibroblast-like morphology and isolated from the bone marrow via plastic adhesion. Their multipotency and immunoregulatory properties make MSCs possible therapeutic agents, and an increasing number ...
Chengzhu Zhao, M. Ikeya
semanticscholar   +1 more source

Generation of hiPSC lines with fusion tagged thyroid hormone receptor α isoforms to study isoform-specific actions of TRα1 and TRα2

Stem Cell Research
The role of the nuclear thyroid hormone receptor TRα1 as a mediator of thyroid hormone action on target gene expression is well understood. However, the function of the TRα2 splicing isoform, which does not bind thyroid hormones, remains unexplored.
Nina Härting, Katarzyna A. Ludwik, Regina Jahn, Frank J. Kaiser, Harald Stachelscheid   +4 more
doaj   +1 more source

Supporting dataset of two integration-free induced pluripotent stem cell lines from related human donors

Data in Brief, 2021
Integration-free induced pluripotent stem cells from related human donors’ exhibit great potential to the ongoing development of organ models. Blood cells from two different human donors were isolated, purified and reprogrammed into induced pluripotent ...
Anja Patricia Ramme, Daniel Faust, Leopold Koenig, Nhutuyen Nguyen, Uwe Marx   +4 more
doaj   +1 more source

Generation of 5 hiPSC lines from pediatric patients with Heritable pulmonary arterial hypertension (HPAH) caused by heterozygous mutations in the TBX4 gene

Stem Cell Research
Heritable pulmonary arterial hypertension (HPAH) and underlying pulmonary vascular disease (PVD) are often caused by TBX4 mutations—either loss- or gain-of-function—which are a leading cause of childhood-onset PAH.
Valeria Fernandez Vallone, Kristin Fischer, Judit Küchler, Franziska Diekmann, Georg Hansmann, Harald Stachelscheid   +5 more
doaj   +1 more source

Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin

Haematologica, 2015
Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells.
Isabel Dorn, Katharina Klich, Marcos J. Arauzo-Bravo, Martina Radstaak, Simeon Santourlidis, Foued Ghanjati, Teja F. Radke, Olympia E. Psathaki, Gunnar Hargus, Jan Kramer, Martin Einhaus, Jeong Beom Kim, Gesine Kögler, Peter Wernet, Hans R. Schöler, Peter Schlenke, Holm Zaehres   +16 more
doaj   +1 more source

Cell Therapy for Type 1 Diabetes [PDF]

, 2014
Acknowledgements The work described in this review was supported by a grant from the MRC. K.R.M. is supported by a fellowship from the Scottish Translational Medicines and Therapeutics Initiative through the Wellcome Trust.Peer reviewedPublisher ...
Docherty, H. M., Docherty, K., Lima, M. J., Muir, K. R.   +3 more
core   +1 more source

Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications

Signal Transduction and Targeted Therapy
The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and holds great promise to advance regenerative medicine. iPSCs have the capacity for an almost unlimited expansion, are amenable to genetic engineering, and can be ...
Jonas Cerneckis, Hongxia Cai, Yanhong Shi   +2 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source