Results 41 to 50 of about 959,542 (406)

Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) are adult stem cells with fibroblast-like morphology and isolated from the bone marrow via plastic adhesion. Their multipotency and immunoregulatory properties make MSCs possible therapeutic agents, and an increasing number ...
Chengzhu Zhao, M. Ikeya
semanticscholar   +1 more source

Derivation of trophoblast stem cells from naïve human pluripotent stem cells

eLife, 2020
Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell fate decisions during pre-implantation development, but their lineage potential remains incompletely characterized.
C. Dong, Mariana Beltcheva, P. Gontarz, Bo Zhang, Pooja Popli, Laura A. Fischer, S. Khan, Kyoung-mi Park, Eun-Ja Yoon, X. Xing, R. Kommagani, Ting Wang, L. Solnica-Krezel, T. Theunissen   +13 more
semanticscholar   +1 more source

Transgene Reactivation in Induced Pluripotent Stem Cell Derivatives and Reversion to Pluripotency of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells [PDF]

Stem Cells and Development, 2016
Induced pluripotent stem cells (iPSCs) have enormous potential in regenerative medicine and disease modeling. It is now felt that clinical trials should be performed with iPSCs derived with nonintegrative constructs. Numerous studies, however, including those describing disease models, are still being published using cells derived from iPSCs generated ...
Mariana Perepitchka, Yekaterina Galat, Philip M. Iannaccone, Mary J.C. Hendrix, Vasiliy Galat, Lawrence J. Jennings   +5 more
openaire   +3 more sources

Supporting dataset of two integration-free induced pluripotent stem cell lines from related human donors

Data in Brief, 2021
Integration-free induced pluripotent stem cells from related human donors’ exhibit great potential to the ongoing development of organ models. Blood cells from two different human donors were isolated, purified and reprogrammed into induced pluripotent ...
Anja Patricia Ramme, Daniel Faust, Leopold Koenig, Nhutuyen Nguyen, Uwe Marx   +4 more
doaj   +1 more source

Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]

, 2016
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai, Liu, Yan-Qun, Xie, Chong, Zhang, Guang-Xian   +3 more
core   +2 more sources

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

Nature Network Boston, 2018
CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-wide screens in human cells1–3. Whereas some cell types are amenable to genome engineering, genomes of human pluripotent stem cells (hPSCs) have been difficult to engineer,
Robert J Ihry, Kathleen A. Worringer, M. Salick, Elizabeth Frias, Daniel J. Ho, Kraig M. Theriault, Sravya Kommineni, Julie T. Chen, M. Sondey, Chaoyang Ye, Ranjit Randhawa, Tripti Kulkarni, Zinger Yang, Gregory McAllister, Carsten Russ, John Reece-Hoyes, W. Forrester, G. Hoffman, R. Dolmetsch, A. Kaykas   +19 more
semanticscholar   +1 more source

Cardiac Differentiation of Pluripotent Stem Cells [PDF]

Stem Cells International, 2011
The ability of human pluripotent stem cells to differentiate towards the cardiac lineage has attracted significant interest, initially with a strong focus on regenerative medicine. The ultimate goal to repair the heart by cardiomyocyte replacement has, however, proven challenging. Human cardiac differentiation has been difficult to control, but methods
Rajala, Kristiina, Pekkanen-Mattila, Mari, Aalto-Setälä, Katriina   +2 more
openaire   +4 more sources

Generation of an isogenic iPSC line via CRISPR correction of the POMC:W84X mutation for monogenic obesity modeling

Stem Cell Research
We report the generation of a genetically corrected induced pluripotent stem cell (iPSC) line, BIHi261-A-1, derived from the patient-specific iPSC line BIHi261-A carrying a homozygous truncating mutation in the POMC gene (POMC:W84X). This mutation causes
Katarzyna A. Ludwik, Valeria Fernandez Valone, Regina Jahn, Sabine Jyrch, Lara Lechner, Peter Kühnen, Harald Stachelscheid   +6 more
doaj   +1 more source

Investigating the functionality of an OCT4-short response element in human induced pluripotent stem cells. [PDF]

, 2016
Pluripotent stem cells offer great therapeutic promise for personalized treatment platforms for numerous injuries, disorders, and diseases. Octamer-binding transcription factor 4 (OCT4) is a key regulatory gene maintaining pluripotency and self-renewal ...
Awe, Jason P, Byrne, James A, Chang, Katherine M, Hermann, Kip J, Lee, Patrick C, Lipshutz, Gerald S, Schoenberg, Benjamen E, Truong, Brian, Vega-Crespo, Agustin, Wu, Lily   +9 more
core   +3 more sources

Generation of human induced pluripotent stem cell line from an obesity patient with POMC deficiency due to POMC:W84X mutation

Stem Cell Research
We generated the human induced pluripotent stem cell (iPSC) line BIHi261-A from dermal fibroblasts of a patient with severe early-onset obesity caused by a homozygous truncating mutation in the POMC gene (W84X).
Katarzyna A. Ludwik, Regina Jahn, Sabine Jyrch, Lara Lechner, Valeria Fernandez Valone, Peter Kühnen, Harald Stachelscheid   +6 more
doaj   +1 more source