Results 71 to 80 of about 57,867 (297)

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Polyethylene glycol and prevalence of colorectal adenomas : Population-based study of 1165 patients undergoing colonoscopy [PDF]

, 2006
Background and aim — Dietary polyethylene glycol (PEG) is extraordinarily potent in the chemoprevention of experimental colon carcinogenesis. PEG is used to treat constipation in France and in the USA. French laxatives include Forlax® (PEG4000), Movicol®
Barbieux, Jean-Pierre, Bertrand, Philippe, Bougnoux, Philippe, Brondin, Brigitte, Corpet, Denis E., Dorval, Etienne, Jankowski, Jean Marie, Viguier, Jérôme   +7 more
core  

Preclinical evaluation of local prolonged release of paclitaxel from gelatin microspheres for the prevention of recurrence of peritoneal carcinomatosis in advanced ovarian cancer [PDF]

, 2019
Patients with advanced ovarian cancer develop recurrence despite initial treatment response to standard treatment of surgery and intravenous/intraperitoneal (IP) chemotherapy, partly due to a limited peritoneal exposure time of chemotherapeutics ...
Ceelen, Wim, De Clercq, Kaat, De Wever, Olivier, Descamps, Benedicte, Hoorens, Anne, Vermeulen, An, Vervaet, Chris, Xie, Feifan   +7 more
core   +2 more sources

Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues

Advanced Healthcare Materials, EarlyView.
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman, Hadas Oved, Itay Gil, Amgad Marzook, Ester Sapir Baruch, Yahel Shechter, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Pluronic block copolymers and Pluronic poly(acrylic acid) microgels in oral delivery of megestrol acetate

Journal of Pharmacy and Pharmacology, 2004
Abstract Several Pluronic-based formulations were studied in-vitro and in a rat model with respect to the release and bioavailability of megestrol acetate (MA) after oral administration. It was demonstrated that an aqueous, micellar formulation comprising a mixture of a hydrophobic (L61) and a hydrophilic (F127) Pluronic copolymer ...
Valery, Alakhov, Grzegorz, Pietrzynski, Kishore, Patel, Alexander, Kabanov, Lev, Bromberg, T Alan, Hatton   +5 more
openaire   +2 more sources

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Numerical investigation of moving gel wall formation in a Y-shaped microchannel

SN Applied Sciences, 2023
Molecular diffusive membranes play crucial roles in the field of microfluidics for biological applications e.g., 3D cell culture and biosensors. Hydrogels provide a range of benefits such as free diffusion of small molecules, cost-effectiveness, and the ...
Donya Dabiri, Mohammad Dehghan Banadaki, Vahid Bazargan, Allison Schaap   +3 more
doaj   +1 more source

Effects of various penetration enhancers on percutaneous absorption of piroxicam from emulgels [PDF]

, 2012
A suitable emulgel formulation of piroxicam was prepared and its percutaneous permeation was investigated using Wistar rat skin and diffusion cell technique.
Azarmi, Sh, Fasihi, Z, Hallaj-Nezhadi, S, Javadzadeh, Y, Nokhodchi, A, Shokri, J   +5 more
core   +2 more sources

Structure of nanoparticles embedded in micellar polycrystals

, 2012
We investigate by scattering techniques the structure of water-based soft composite materials comprising a crystal made of Pluronic block-copolymer micelles arranged in a face-centered cubic lattice and a small amount (at most 2% by volume) of silica ...
Alexandridis P., Alexandridis P., Balazs A. C., Bartlett P., Bockstaller M. R., Boucenna I., Cipelletti L, de Villeneuve V. W. A., Diat O., Duan H., Duhr S., Elisa Tamborini, Ferri F., Glotzer S. C., Grzelczak M., Gudiksen M. S., Haryono A., Herzig E. M., Iler R. K., Julian Oberdisse, Kim J., Kobayashi M., Laurence Ramos, Law M., Lee Y. C., Lin Y., Lindner P., Losert W., Luca Cipelletti, Mann S., Mortensen K., Neda Ghofraniha, Pozzo D. C., Pozzo D. C., Pozzo D. C., Sarikaya M, Schofield A. B., Schroën C. G. P. H., Shar J. A., Sharma K. P., Sharma K. P., Spannuth M., Stipp A., Sun K., Veugopal E., Wu C., Xu C., Yardimci H.   +47 more
core   +3 more sources

Microwave-assisted embedding of bis-vanillin and bis-eugenol into SBA-15: Synthesis of chemosensors precursors for the detection of metal cations [PDF]

, 2017
In this work we evaluate the necessary experimental conditions to carry out the embedding of bis-vanillin and bis-eugenol, two potential precursors of chemosensors, in the porous structure of the mesoporous silica SBA-15 through a microwave assisted ...
Espinoza Martinez, Dailenys, Ferretti, Cristián Alejandro, Guntero, Vanina Alejandra, Kneeteman, Maria Nelida, Mancini, Pedro Maximo Emilio   +4 more
core   +1 more source