Results 31 to 40 of about 21,552 (215)
Journal of Animal Reproduction and Biotechnology, 2021 Increasing the efficiency of HR (homologous recombination) is important for a successful knock-in. Rad51 is mainly involved in homologous recombination and is associated with strand invasion. The HR-related mismatch repair system maintains HR fidelity by
Hyeong-Ju You +3 more
doaj +1 more source
PMS2-associated Lynch syndrome: Past, present and future
Frontiers in Oncology, 2023 Carriers of any pathogenic variant in one of the MMR genes (path_MMR carriers) were traditionally thought to be at comparable risk of developing a range of different malignancies, foremost colorectal cancer (CRC) and endometrial cancer.
Katarina D. Andini +10 more
doaj +1 more source
Immunohistochemical phenotype of colorectal carcinoma in patients with KRAS mutation and mismatch repair status [PDF]
Folia Medica, 2023 Introduction: Aberrant expression of CK7/CK20/CDX2 is reported in percentage of colorectal carcinomas (CRC). Aim: The objective of this study was to investigate specific morphological and immunohistochemical characteristics of colorectal
Desislava Tashkova +6 more
doaj +3 more sources
FGFR2 amplification in colorectal adenocarcinoma [PDF]
, 2017 FGFR2 is recurrently amplified in 5% of gastric cancers and 1%–4% of breast cancers; however, this molecular alteration has never been reported in a primary colorectal cancer specimen.
Carter, Jamal H +6 more
core +2 more sources
Clinical utility gene card for: Lynch syndrome (MLH1, MSH2, MSH6, PMS2) [PDF]
European Journal of Human Genetics, 2010 (1) Clinical selection1: Lynch-related cancer (colon, rectum, endometrium, urinary tract, small bowel, biliary tract, ovary, stomach). Sporadic before 50 years of age, first-degree relative or prior Lynch-related cancer. (2) Study of MMR function in tumour cells2: microsatellite DNA analysis—genotyping of the consensus panel of five mononucleotidic ...
Nils, Rahner +5 more
openaire +2 more sources
Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients. [PDF]
, 2017 PurposeMany women with an elevated risk of hereditary breast and ovarian cancer have previously tested negative for pathogenic mutations in BRCA1 and BRCA2. Among them, a subset has hereditary susceptibility to cancer and requires further testing.
Adams, Sophie B +8 more
core +1 more source
Evaluation of microsatellite instability in routine examinations of surgical samples
Indian Journal of Pathology and Microbiology, 2022 Context: Approximately 20%–30% of colon cancer cases have a hereditary basis. The genetic defect may involve mismatch repair (MMR) genes, which results in microsatellite instability (MSI).
Pawel Wlaszczuk +4 more
doaj +1 more source
Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. [PDF]
, 2016 Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. Observed during CRC tumorigenesis is loss of post-transcriptional regulation of tumor-promoting genes such as COX-2, TNFα and VEGF. Overexpression of
Aguado, Andrea +12 more
core +2 more sources
Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells
Oncotarget, 2015 DNA mismatch repair (MMR) enzymes act as proofreading complexes that maintains genomic integrity and MMR-deficient cells show an increased mutation rate. MMR has also been shown to influence cell signaling and the regulation of tumor development. MMR consists of various genes and includes post-meiotic segregation (PMS) 2 which is a vital component of ...
Shinichiro, Fukuhara +14 more
openaire +6 more sources