Results 51 to 60 of about 21,552 (215)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Mismatch repair enzyme expression in primary and castrate resistant prostate cancer

Asian Journal of Urology, 2016
Objective: Although the utility of immunohistochemistry (IHC) for assessing mismatch repair (MMR) protein expression has been demonstrated in solid tumors including primary prostate cancer (PCa), its utility has not been assessed in castration-resistant ...
Belinda Nghiem, Xiaotun Zhang, Hung-Ming Lam, Lawrence D. True, Ilsa Coleman, Celestia S. Higano, Peter S. Nelson, Colin C. Pritchard, Colm Morrissey   +8 more
doaj   +1 more source

Evaluation of current prediction models for Lynch syndrome: updating the PREMM5 model to identify PMS2 mutation carriers [PDF]

, 2017
Until recently, no prediction models for Lynch syndrome (LS) had been validated for PMS2 mutation carriers. We aimed to evaluate MMRpredict and PREMM5 in a clinical cohort and for PMS2 mutation carriers specifically.
Bruno, M.J. (Marco), Dinjens, W.N.M. (Winand), Dubbink, H.J. (Erik Jan), Goverde, A. (Anne), Hofstra, R.M.W. (Robert), Nieboer, D. (Daan), Ouweland, A.M.W. (Ans) van den, Spaander, M.C.W. (Manon), Steyerberg, E.W. (Ewout), Ten Broeke, S.W. (Sanne W.), Tops, C. (Cmj), Wagner, A. (Anja)   +11 more
core   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Polymorphism of DNA repair system protein genes and its association with chronic viral hepatitis C

Инфекция и иммунитет
Hepatitis C is an infectious disease that causes liver inflammation and often leads to a chronic process. The genes encoding proteins involved in DNA repair systems participate in developing immune responses and inflammation, making them promising ...
Nadezhda P. Babushkina, V. E. Shavrak, I. A. Goncharova, E. V. Beloborodova   +3 more
doaj   +1 more source

Genetic anticipation in Swedish Lynch syndrome families.

PLoS Genetics, 2017
Among hereditary colorectal cancer predisposing syndromes, Lynch syndrome (LS) caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 is the most common.
Jenny von Salomé, Philip S Boonstra, Masoud Karimi, Gustav Silander, Marie Stenmark-Askmalm, Samuel Gebre-Medhin, Christos Aravidis, Mef Nilbert, Annika Lindblom, Kristina Lagerstedt-Robinson   +9 more
doaj   +1 more source

Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers [PDF]

, 2010
Background: Reported prevalence, penetrance and expression of deleterious mutations in the mismatch repair (MMR) genes, MLH1, MSH2, MSH6 and PMS2, may reflect differences in the clinical criteria used to select families for DNA testing.
Sjursen, Wenche, Haukanes, Bjørn Ivar, Grindedal, Eli Marie, Aarset, Harald, Stormorken, Astrid Tenden, Engebretsen, Lars Fredrik, Jonsrud, Christoffer, Bjørnevoll, Inga, Andresen, Per Arne, Ariansen, Sarah, Lavik, Liss Anne S., Gilde, Bodil, Bowitz-Lothe, Inger Marie, Mæhle, Lovise, Møller, Pål   +14 more
core   +1 more source

Association of expression of inflammatory response genes and DNA repair genes in colorectal carcinoma

Tumor Biology, 2019
Inflammation is an important etiological factor of colorectal carcinoma and may be related to colorectal carcinoma growth and proliferation. This study aimed to verify whether the presence of chronic inflammation represented by tumor necrosis factor-α ...
Demétrius Eduardo Germini, Maria Isete Fares Franco, Fernando Luiz Affonso Fonseca, Flávia de Sousa Gehrke, Beatriz da Costa Aguiar Alves Reis, Leonardo Cardili, Celina Tizuko Fujiyama Oshima, Thérèse Rachell Theodoro, Jaques Waisberg   +8 more
doaj   +1 more source

A case of Turcot’s syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report

BMC Medical Genetics, 2020
Background Lynch syndrome (LS), which is known as a hereditary cancer syndrome, is distinguished by microsatellite instability, represented by the altered number of repetitive sequences in the coding and/or non-coding region. Immunohistochemical staining
Shintaro Akabane, Takao Hinoi, Kiwamu Akagi, Hideki Yamamoto, Haruki Sada, Yosuke Shimizu, Wataru Shimizu, Takeshi Sudo, Takashi Onoe, Kohei Ishiyama, Takahisa Suzuki, Hirofumi Tazawa, Naoto Hadano, Toshihiro Misumi, Masato Kojima, Haruna Kubota, Daiki Taniyama, Kazuya Kuraoka, Hirotaka Tashiro   +18 more
doaj   +1 more source

Outcomes of Genetic Testing in a Genitourinary Genetics Clinic [PDF]

, 2018
Several known hereditary cancer syndromes confer an increased risk for genitourinary (GU)related malignancies. Various guidelines indicate when to refer patients to genetic counseling for GU-related hereditary cancer syndromes but there is limited ...
Pace, Annelise
core   +1 more source