Revista Portuguesa de Pneumologia, 2005 Resumo: O diagnóstico diferencial do Mycobacterium bovis é importante no controlo da transmissão para a população humana e também no tratamento da doença, visto que o M. bovis é naturalmente resistente à pirazinamida.
Suzana David +7 more
doaj +1 more source
Pyrazinamide resistance associated with pncA gene mutation in Mycobacterium tuberculosis in Japan
Epidemiology and Infection, 2002 Thirty Japanese clinical isolates of Mycobacterium tuberculosis were analysed by pyrazinamide susceptibility testing and pyrazinamidase assay, as well as polymerase chain reaction for single-strand conformational polymorphism and direct sequencing of the gene encoding pyrazinamidase (pncA).
T, Endoh +8 more
openaire +3 more sources
Non-synonymous mutations in pncA and their presence in the published lists. [PDF]
, 2019 Non-synonymous mutations in pncA and their presence in the published lists.
Satoshi Mitarai (687324) +11 more
core +1 more source
pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates from the southeast region of Brazil [PDF]
, 2006 Objectives: To investigate the presence of mutations in the pncA gene in 31 pyrazinamide-resistant Mycobacterium tuberculosis and 5 susceptible strains. MICs and pyrazinamidase (PZase) activity were also determined.Methods: All 36 M.
Shikama, M. L. +11 more
core +1 more source
Screening mutations in drug-resistant Mycobacterium tuberculosis strains in Yunnan, China
Journal of Infection and Public Health, 2017 Drug-resistant tuberculosis (DR-TB), especially multidrug-resistant tuberculosis (MDR-TB), is a serious medical and societal problem in China. The purpose of this study was to evaluate the mutation characteristics of drug-resistant Mycobacterium ...
Daoqun Li +5 more
doaj +1 more source
Distribution of reported single nucleotide polymorphisms (SNPs) throughout the pncA gene. [PDF]
, 2015 Dashed lines indicate the open reading frame for the pncA gene.
Annelies van Rie (5664598) +7 more
core +1 more source
Inscriptions, 2022 This is the third in a series of essays, linked thoughts about change over time. In the space of very few years in world historical terms, English beaches and wave-like rolling hills were transformed.
David Ritchie
doaj
Correlation of pncA sequences with pyrazinamide resistance level in BACTECtm for 21 Mycobacterium tuberculosis clinical isolates [PDF]
, 2000 Mutations in the pncA gene, encoding pyrazinamidase, are considered the major mechanism of pyrazinamide (PZA) resistance in Mycobacterium tuberculosis, but resistant strains containing the wild-type gene have been described.
Mestdagh, M. +8 more
core
pncA Mutations as a Major Mechanism of Pyrazinamide Resistance in Mycobacterium tuberculosis : Spread of a Monoresistant Strain in Quebec, Canada [PDF]
, 2000 Pyrazinamide (PZA) is an important first-line tuberculosis drug that is part of the currently used short-course tuberculosis chemotherapy. PZA is a prodrug that has to be converted to the active form pyrazinoic acid by pyrazinamidase (PZase) activity ...
Louise Thibert +4 more
core +1 more source