Purine nucleoside phosphorylase as a target for the treatment of interstitial cystitis/bladder pain syndrome with and without Hunner lesions [PDF]
Scientific ReportsChronic visceral pain disorders, such as interstitial cystitis/bladder pain syndrome (IC/BPS), are difficult to treat, and therapies are limited in number and efficacy.
Lori A. Birder +6 more
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Selective RNA Processing and Stabilization are Multi‐Layer and Stoichiometric Regulators of Gene Expression in Escherichia coli [PDF]
Advanced Science, 2023 Selective RNA processing and stabilization (SRPS) facilitates the differential expression of multiple genes in polycistronic operons. However, how the coordinated actions of SRPS‐related enzymes affect stoichiometric regulation remains unclear.
Daixi Liu +5 more
doaj +2 more sources
Rapid Degradation of Hfq-Free RyhB inYersinia pestisby PNPase Independent of Putative Ribonucleolytic Complexes [PDF]
BioMed Research International, 2014 The RNA chaperone Hfq in bacteria stabilizes sRNAs by protecting them from the attack of ribonucleases. Upon release from Hfq, sRNAs are preferably degraded by PNPase. PNPase usually forms multienzyme ribonucleolytic complexes with endoribonuclease E and/
Zhongliang Deng +6 more
semanticscholar +5 more sources
Suppression of PNPase Alleviates Gestational Diabetes Mellitus-cardiovascular Injury through Up-regulating MicroRNA-26a and Down-regulating PTEN [PDF]
, 2021 Objective: Gestational diabetes mellitus (GDM) is often accompanied by cardiovascular injury (CI), while the specific pathology remains largely unknown.
Li Liu, Hai-Ying Wu, Xianghong Cheng
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Ring around the Ro-sie: RNA-Mediated Alterations of PNPase Activity [PDF]
Cell, 2013 Chen et al. demonstrate a new way by which noncoding RNAs tailor the function of multicomponent complexes. They show that a noncoding RNA interacts with an exoribonuclease, altering its substrate specificity and enzymatic activity by serving as a ribonucleoprotein scaffold and, perhaps, a gate for entry of the RNA substrate.
Brian J. Geiss, Jeffrey Wilusz
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Rapid and scalable detection of synthetic mRNA byproducts using polynucleotide phosphorylase and polythymidine oligonucleotides [PDF]
RNA BiologyProduction and storage of synthetic mRNA can introduce a variety of byproducts which reduce the overall integrity and functionality of mRNA vaccines and therapeutics.
Francis Combes +3 more
doaj +2 more sources
Loop-mediated regulation and base flipping drive RNA cleavage by human mitochondrial PNPase. [PDF]
Nucleic Acids ResHuman polynucleotide phosphorylase (hPNPase), a trimeric exoribonuclease, is crucial for maintaining mitochondrial RNA metabolism, including the regulated degradation of RNA.
Unseld O, Das H, Hällberg BM.
europepmc +2 more sources
PNPase activity determines the efficiency of mRNA 3'-end processing, the degradation of tRNA and the extent of polyadenylation in chloroplasts [PDF]
EMBO Journal, 2002 Michael Walter, Joerg Kudla
exaly +2 more sources
PNPase IN C. ELEGANS: MUTAGENIC ANALYSIS TO COMPLEMENT KNOCKDOWN STUDIES
, 2017 VCU Theses and ...
Danielle K. Seibert
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