Results 21 to 30 of about 4,003 (181)

Mitochondrial sequencing identifies long noncoding RNA features that promote binding to PNPase.

Am J Physiol Cell Physiol
Extranuclear localization of long non-coding RNAs (lncRNAs) is poorly understood. Based on machine learning evaluations, we propose a lncRNA-mitochondrial interaction pathway where Polynucleotide Phosphorylase (PNPase), through domains that provide ...
Taylor AD, Hathaway QA, Kunovac A, Pinti MV, Newman MS, Cook CC, Cramer ER, Starcovic SA, Winters MT, Westemeier-Rice ES, Fink GK, Durr AJ, Rizwan S, Shepherd DL, Robart AR, Martinez I, Hollander JM.   +16 more
europepmc   +2 more sources

The Protein Interaction of RNA Helicase B (RhlB) and Polynucleotide Phosphorylase (PNPase) Contributes to the Homeostatic Control of Cysteine in Escherichia coli

Journal of Biological Chemistry, 2015
PNPase, one of the major enzymes with 3′ to 5′ single-stranded RNA degradation and processing activities, can interact with the RNA helicase RhlB independently of RNA degradosome formation in Escherichia coli.
Sue Lin-Chao, Yi-Ting Tseng
exaly   +2 more sources

Purine nucleoside phosphorylase as a target for the treatment of interstitial cystitis/bladder pain syndrome with and without Hunner lesions [PDF]

Scientific Reports
Chronic visceral pain disorders, such as interstitial cystitis/bladder pain syndrome (IC/BPS), are difficult to treat, and therapies are limited in number and efficacy.
Lori A. Birder, Amanda Wolf-Johnston, Vladimir Ritov, Joel N. H. Stern, Robert Moldwin, Hann-Chorng Kuo, Edwin K. Jackson   +6 more
doaj   +2 more sources

Rationale for the Use of 8-Aminoguanine for the Management of Cystitis. [PDF]

Int J Urol
ABSTRACT Bladder pain and associated lower urinary tract symptoms (LUTSs) are hallmark features of interstitial cystitis/bladder pain syndrome (IC/BPS) and hemorrhagic cystitis (HC). IC/BPS is characterized by bladder‐based pain and irritative bladder symptoms, with or without gross inflammatory changes (Hunner lesions) in the bladder wall, and the ...
Birder LA, Stern JNH, Moldwin R, Jackson EK.   +3 more
europepmc   +2 more sources

Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosol [PDF]

Life Science Alliance
Mitochondrial double-stranded RNA is a new signaling molecule that, likely under stress conditions, is exported to induce a type 1 interferon response, thus mimicking a viral response. This export pathway is detected in a subset of lung cancer cell lines.
Matthew R Krieger, Melania Abrahamian, Kevin L He, Sean Atamdede, Hesamedin Hakimjavadi, Milica Momcilovic, Dejerianne Ostrow, Simran DS Maggo, Yik Pui Tsang, Xiaowu Gai, Guillaume F Chanfreau, David B Shackelford, Michael A Teitell, Carla M Koehler   +13 more
doaj   +2 more sources

Enolase binds to RnpA in competition with PNPase in Staphylococcus aureus

FEBS Letters, 2017
Chengliang Wang, Tian Tian
exaly   +2 more sources

RNase-mediated reprogramming of Yersinia virulence. [PDF]

PLoS Pathogens
RNA degradation is an essential process that allows bacteria to regulate gene expression and has emerged as an important mechanism for controlling virulence. However, the individual contributions of RNases in this process are mostly unknown.
Ines Meyer, Marcel Volk, Ileana Salto, Theresa Moesser, Paweena Chaoprasid, Anne-Sophie Herbrüggen, Manfred Rohde, Michael Beckstette, Ann Kathrin Heroven, Petra Dersch   +9 more
doaj   +2 more sources

Structure and function of Campylobacter jejuni polynucleotide phosphorylase (PNPase): Insights into the role of this RNase in pathogenicity.

Biochimie, 2023
Ribonucleases are in charge of the processing, degradation and quality control of all cellular transcripts, which makes them crucial factors in RNA regulation.
C. Bárria, D. Athayde, G. Hernandez, L. Fonseca, Jorge Casinhas, Tiago N. Cordeiro, Margarida Archer, C. Arraiano, J. Brito, R. Matos   +9 more
semanticscholar   +1 more source

Polynucleotide phosphorylase: Not merely an RNase but a pivotal post-transcriptional regulator. [PDF]

PLoS Genetics, 2018
Almost 60 years ago, Severo Ochoa was awarded the Nobel Prize in Physiology or Medicine for his discovery of the enzymatic synthesis of RNA by polynucleotide phosphorylase (PNPase).
Todd A Cameron, Lisa M Matz, Nicholas R De Lay   +2 more
doaj   +1 more source

Target recognition by RNase E RNA-binding domain AR2 drives sRNA decay in the absence of PNPase

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance RNase E performs an indispensable function in gram-negative bacteria by initiating breakdown of cellular RNAs and providing the scaffold for the primary RNA decay machine, the RNA degradosome.
D. Sinha, Nicholas R. De Lay
semanticscholar   +1 more source