Results 11 to 20 of about 4,003 (181)

PNPase is involved in the coordination of mRNA degradation and expression in stationary phase cells of Escherichia coli

BMC Genomics, 2018
Background Exoribonucleases are crucial for RNA degradation in Escherichia coli but the roles of RNase R and PNPase and their potential overlap in stationary phase are not well characterized.
Clémentine Dressaire, Vânia Pobre, Sandrine Laguerre, Laurence Girbal, Cecilia Maria Arraiano, Muriel Cocaign-Bousquet   +5 more
doaj   +4 more sources

Lack of PNPase activity in Enterococcus faecalis 14 increases the stability of EntDD14 bacteriocin transcripts

Scientific Reports, 2023
A mutant deficient in polynucleotide phosphorylase (PNPase) activity was previously constructed in Enterococcus faecalis 14; a strain producing a leaderless two-peptide enterocin DD14 (EntDD14).
Rabia Ladjouzi, Anca Lucau-Danila, Paloma López, Djamel Drider   +3 more
doaj   +3 more sources

PNPase knockout results in mtDNA loss and an altered metabolic gene expression program. [PDF]

PLoS ONE, 2018
Polynucleotide phosphorylase (PNPase) is an essential mitochondria-localized exoribonuclease implicated in multiple biological processes and human disorders.
Eriko Shimada, Fasih M Ahsan, Mahta Nili, Dian Huang, Sean Atamdede, Tara TeSlaa, Dana Case, Xiang Yu, Brian D Gregory, Benjamin J Perrin, Carla M Koehler, Michael A Teitell   +11 more
doaj   +3 more sources

Regulation and functions of bacterial PNPase [PDF]

Wiley Interdisciplinary Reviews RNA, 2016
Polynucleotide phosphorylase (PNPase) is an exoribonuclease that catalyzes the processive phosphorolytic degradation of RNA from the 3′-end. The enzyme catalyzes also the reverse reaction of polymerization of nucleoside diphosphates that has been ...
Giovanni Deho', Thomas Carzaniga, Federica Briani   +2 more
exaly   +3 more sources

Structural insights into human PNPase in health and disease. [PDF]

Nucleic Acids Res
Human polynucleotide phosphorylase (hPNPase) is a 3′-to-5′ exoribonuclease located in mitochondria, where it plays crucial roles in RNA degradation and RNA import.
Li YC, Wang CH, Patra M, Chen YP, Yang WZ, Yuan HS.   +5 more
europepmc   +2 more sources

8-Aminoguanine protects against paclitaxel-induced neural degeneration and mechanical allodynia [PDF]

JCI Insight
Current treatment protocols for most types of cancers require chemotherapeutic agents that are associated with significant side effects, including chemotherapy-induced peripheral neuropathy (CIPN).
Lori A. Birder, Amanda Wolf-Johnston, Jonathan Franks, Mara L.G. Sullivan, Simon C. Watkins, Anthony J. Kanai, Vladimir B. Ritov, Edwin K. Jackson   +7 more
doaj   +2 more sources

Regulatory Mechanisms of Exoribonuclease PNPase and Regulatory Small RNA on T3SS of Dickeya dadantii

Molecular Plant-Microbe Interactions, 2010
The type III secretion system (T3SS) is an essential virulence factor for many bacterial pathogens. Polynucleotide phosphorylase (PNPase) is one of the major exoribonucleases in bacteria and plays important roles in mRNA degradation, tRNA processing, and
Quan Zeng, A. Mark Ibekwe, Eulandria Biddle, Ching-Hong Yang   +3 more
doaj   +2 more sources

Mitochondrial RNA degradation regulates differentiation, stemness, and immune sensitivity in acute myeloid leukemia [PDF]

Nature Communications
Eukaryotic cells have separate genomes in the nucleus and mitochondria. Mitochondrial DNA is transcribed bi-directionally to generate mitochondrial RNA (mtRNA) and dsRNA as a by-product of this transcription.
Geethu Emily Thomas, Veronique Voisin, Kazem Nouri, Rose Hurren, Karen Kai-Lin Fang, Ali Chegini, Marcela Gronda, Yongran Yan, Neil MacLean, Yulia Jitkova, Dakai Ling, Mary Ma, Xiao Ming Wang, Andrea Arruda, Vito Spadavecchio, Mark D. Minden, Li Zhang, Jong Bok Lee, Aaron D. Schimmer   +18 more
doaj   +2 more sources

A PNPase dependent CRISPR System in Listeria. [PDF]

PLoS Genetics, 2014
The human bacterial pathogen Listeria monocytogenes is emerging as a model organism to study RNA-mediated regulation in pathogenic bacteria. A class of non-coding RNAs called CRISPRs (clustered regularly interspaced short palindromic repeats) has been ...
Nina Sesto, Marie Touchon, José Marques Andrade, Jiro Kondo, Eduardo P C Rocha, Cecilia Maria Arraiano, Cristel Archambaud, Éric Westhof, Pascale Romby, Pascale Cossart   +9 more
doaj   +3 more sources

Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase)

Journal of Molecular and Cellular Cardiology, 2017
Cardiovascular disease is the primary cause of mortality for individuals with type 2 diabetes mellitus. During the diabetic condition, cardiovascular dysfunction can be partially attributed to molecular changes in the tissue, including alterations in ...
John Hollander, Quincy A Hathaway, Mark V Pinti   +2 more
exaly   +2 more sources