Results 31 to 40 of about 4,003 (181)

A cooperative PNPase-Hfq-RNA carrier complex facilitates bacterial riboregulation. [PDF]

, 2021
Polynucleotide phosphorylase (PNPase) is an ancient exoribonuclease conserved in the course of evolution and is found in species as diverse as bacteria and humans.

core   +3 more sources

The absence of PNPase activity in Enterococcus faecalis results in alterations of the bacterial cell-wall but induces high proteolytic and adhesion activities.

Gene, 2022
Enterococci are lactic acid bacteria (LAB) used as starters and probiotics, delineating their positive attributes. Nevertheless, enterococci can be culprit for thousands of infectious diseases, including urinary tract infections, bacteremia and ...
R. Ladjouzi, M. Duban, Anca Lucau-Danila, D. Drider   +3 more
semanticscholar   +1 more source

PNPASE Regulates RNA Import into Mitochondria

RNA import into mammalian mitochondria is considered essential for replication, transcription, and translation of the mitochondrial genome but the pathway(s) and factors that control this import are poorly understood.
Morse HC, Hong JS, French SW, Zhang J, Koehler CM, Allen EL, Lightowlers RN, Wang G, Smith GM, Teitell MA, Fan KC, Chen HW, Oktay Y, McCaffery JM   +13 more
core   +5 more sources

Novel Aspects of Polynucleotide Phosphorylase Function in Streptomyces

Antibiotics, 2018
Polynucleotide phosphorylase (PNPase) is a 3′–5′-exoribnuclease that is found in most bacteria and in some eukaryotic organelles. The enzyme plays a key role in RNA decay in these systems.
George H. Jones
doaj   +1 more source

Analysis of mRNA Decay Intermediates in Bacillus subtilis 3′ Exoribonuclease and RNA Helicase Mutant Strains

mBio, 2022
The Bacillus subtilis genome encodes four 3′ exoribonucleases: polynucleotide phosphorylase (PNPase), RNase R, RNase PH, and YhaM. Previous work showed that PNPase, encoded by the pnpA gene, is the major 3′ exonuclease involved in mRNA turnover; in a ...
Shivani Chhabra, Zachary F. Mandell, Bo Liu, Paul Babitzke, David H. Bechhofer   +4 more
doaj   +1 more source

Polynucleotide Phosphorylase Mediates a New Mechanism of Persister Formation in Escherichia coli

Microbiology Spectrum, 2023
Despite the identification of many genes and pathways involved in the persistence phenomenon in bacteria, the mechanisms of persistence are not well understood.
Nan Wu, Yumeng Zhang, Shanshan Zhang, Youhua Yuan, Shuang Liu, Tao Xu, Peng Cui, Wenhong Zhang, Ying Zhang   +8 more
doaj   +1 more source

Role of the PNPase enzyme in the transport of mtRNA in lymphatic cancer: Bibliographic review

Nereis. Interdisciplinary Ibero-American Journal of Methods, Modelling and Simulation., 2021
Lymphoma is the most common type of blood cancer today and, as its name suggests, it begins in the lymphatic system. The origin of this disease is related to mitochondrial defects, generated by mutations in the PNPase enzyme or polynucleotide ...
Myriam Lizanda Piqueras, Ignacio Ventura González   +1 more
semanticscholar   +1 more source

Polynucleotide phosphorylase is implicated in homologous recombination and DNA repair in Escherichia coli

BMC Microbiology, 2017
Background Polynucleotide phosphorylase (PNPase, encoded by pnp) is generally thought of as an enzyme dedicated to RNA metabolism. The pleiotropic effects of PNPase deficiency is imputed to altered processing and turnover of mRNAs and small RNAs, which ...
Thomas Carzaniga, Giulia Sbarufatti, Federica Briani, Gianni Dehò   +3 more
doaj   +1 more source

Different csrA Expression Levels in C versus K-12 E. coli Strains Affect Biofilm Formation and Impact the Regulatory Mechanism Presided by the CsrB and CsrC Small RNAs

Microorganisms, 2021
Escherichia coli C is a strong biofilm producer in comparison to E. coli K-12 laboratory strains due to higher expression of the pgaABCD operon encoding the enzymes for the biosynthesis of the extracellular polysaccharide poly-β-1,6-N-acetylglucosamine ...
Thomas Carzaniga, Federica A. Falchi, Francesca Forti, Davide Antoniani, Paolo Landini, Federica Briani   +5 more
doaj   +1 more source

Polynucleotide phosphorylase has an impact on cell biology of Campylobacter jejuni

Frontiers in Cellular and Infection Microbiology, 2012
Polynucleotide phosphorylase, encoded by the pnp gene, is known to degrade mRNA, mediating post-transcriptional regulation and may affect cellular functions. The role of PNPase is pleiotropic.
Nabila eHaddad, Nabila eHaddad, Odile eTresse, Odile eTresse, Katell eRivoal, Didier eChevret, Quentin eNonglaton, Quentin eNonglaton, Christopher M. Burns, Hervé ePrévost, Hervé ePrévost, Jean-Michel eCappelier, Jean-Michel eCappelier   +12 more
doaj   +1 more source