Results 61 to 70 of about 4,319 (202)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background 8‐Aminoguanosine and 8‐aminoguanine are K+‐sparing natriuretics that increase glucose excretion. Most effects of 8‐aminoguanosine are due to its metabolism to 8‐aminoguanine.
Edwin K. Jackson +3 more
doaj +1 more source
Elucidating the molecular physiology of lantibiotic NAI-107 production in Microbispora ATCC-PTA-5024 [PDF]
, 2016 BACKGROUND: The filamentous actinomycete Microbispora ATCC-PTA-5024 produces the lantibiotic NAI-107, which is an antibiotic peptide effective against multidrug-resistant Gram-positive bacteria. In actinomycetes, antibiotic production is often associated
Alduina, Rosa +14 more
core +4 more sources
Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. [PDF]
, 2018 The Hsp90 molecular chaperones are ATP-dependent enzymes that maintain protein homeostasis and regulate many essential cellular processes. Higher eukaryotes have organelle-specific Hsp90 paralogs that are adapted to each subcellular environment.
Agard, David A, Elnatan, Daniel
core
Advanced Synthesis &Catalysis, Volume 368, Issue 1, January 2026.Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi +8 more
wiley +1 more source
PNPase autocontrols its expression by degrading a double-stranded structure in the pnp mRNA leader [PDF]
The EMBO Journal, 2001 Polynucleotide phosphorylase synthesis is autocontrolled at a post-transcriptional level in an RNase III-dependent mechanism. RNase III cleaves a long stem-loop in the pnp leader, which triggers pnp mRNA instability, resulting in a decrease in the synthesis of polynucleotide phosphorylase.
Jarrige, Anne-Charlotte +2 more
openaire +3 more sources
Role of the PNPase enzyme in the transport of mtRNA in lymphatic cancer: Bibliographic review
Nereis. Interdisciplinary Ibero-American Journal of Methods, Modelling and Simulation., 2021 Lymphoma is the most common type of blood cancer today and, as its name suggests, it begins in the lymphatic system. The origin of this disease is related to mitochondrial defects, generated by mutations in the PNPase enzyme or polynucleotide phosphorylase, whose main functions are to import and degradation mitochondrial RNA.
Lizanda Piqueras, Myriam +1 more
openaire +3 more sources
Maturation of Polycistronic mRNAs by the Endoribonuclease RNase Y and Its Associated Y-Complex in Bacillus Subtilis [PDF]
, 2018 Endonucleolytic cleavage within polycistronic mRNAs can lead to differential stability, and thus discordant abundance, among cotranscribed genes. RNase Y, the major endonuclease for mRNA decay in Bacillus subtilis, was originally identified for its ...
DeLoughery, Aaron +3 more
core +1 more source
Small Science, Volume 5, Issue 12, December 2025.This review highlights the advances in graphene liquid cell designs for in situ liquid‐phase transmission electron microscopy, spanning veil‐type, well‐type, liquid‐flowing‐type, and mixing‐type configurations. These developments collectively enable real‐time visualization of diverse reactions in liquid environments at atomic resolution, thereby ...
Hyeonjong Ma +2 more
wiley +1 more source
Electron Transfer Precedes ATP Hydrolysis during Nitrogenase Catalysis [PDF]
, 2013 The biological reduction of N2 to NH3 catalyzed by Mo-dependent nitrogenase requires at least eight rounds of a complex cycle of events associated with ATP-driven electron transfer (ET) from the Fe protein to the catalytic MoFe protein, with each ET ...
Antony, Edwin +7 more
core +2 more sources
mLife, Volume 4, Issue 5, Page 516-526, October 2025.Abstract Ribonuclease E (RNase E) is central to bacterial RNA metabolism. In cyanobacteria, its activity is inhibited by RebA, a key mechanism for controlling cell morphology. Here, we demonstrate that rebA is essential for diazotrophic growth of Anabaena PCC 7120, a filamentous cyanobacterium capable of forming heterocysts—specialized nitrogen‐fixing ...
Sujuan Liu +6 more
wiley +1 more source