Results 1 to 10 of about 48,174 (296)

CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis

Cell Death and Disease, 2022
A major cause of proteinuria in lupus nephritis (LN) is podocyte injury, and determining potential therapeutic targets to prevent podocyte injury is important from a clinical perspective in the treatment of LN.
Fu Lv, Yingxin He, Hongde Xu, Yongchun Li, Lipei Han, Lijie Yan, Hui Lang, Yafei Zhao, Zhanzheng Zhao, Yuanyuan Qi   +9 more
doaj   +2 more sources

Controversies in Podocyte Loss: Death or Detachment?

Frontiers in Cell and Developmental Biology, 2021
Glomerular podocytes are characterized by terminally differentiated epithelial cells with limited proliferating ability; thus, podocyte loss could not be fully compensated by podocyte regeneration.
Lijun Yin, Lu Yu, Lu Yu, John Cijiang He, John Cijiang He, Anqun Chen   +5 more
doaj   +2 more sources

Knowledge Domain and Emerging Trends in Podocyte Injury Research From 1994 to 2021: A Bibliometric and Visualized Analysis

Frontiers in Pharmacology, 2021
Background: Podocyte injury has a direct causal relationship with proteinuria and glomerulosclerosis and, on a chronic level, can lead to irreversible disease progression. Podocyte injury plays a critically decisive role in the development of proteinuric
Tongtong Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Yongli Zhan   +5 more
doaj   +2 more sources

Mechanisms of podocyte injury and implications for diabetic nephropathy

Clinical Science, 2022
Albuminuria is the hallmark of both primary and secondary proteinuric glomerulopathies, including focal segmental glomerulosclerosis (FSGS), obesity-related nephropathy, and diabetic nephropathy (DN).
Federica Barutta, Stefania Bellini, Gabriella Gruden   +2 more
exaly   +2 more sources

The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease

Kidney Diseases, 2021
Background: Podocytes, functionally specialized and terminally differentiated glomerular visceral epithelial cells, are critical for maintaining the structure and function of the glomerular filtration barrier.
Yu Sun, Sijia Cui, Yunfeng Hou, Fan Yi
doaj   +2 more sources

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

Nature Communications, 2017
Podocyte injury is a major determinant of proteinuric kidney disease and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance.
Chun Zhang, Chengjiang Gao, Jun Peng
exaly   +2 more sources

Cell‐Derived Extracellular Matrix‐Rich Biomimetic Substrate Supports Podocyte Proliferation, Differentiation, and Maintenance of Native Phenotype

Advanced Functional Materials, 2020
Current technologies and available scaffold materials do not support long‐term cell viability, differentiation, and maintenance of podocytes, the ultra‐specialized kidney resident cells that are responsible for the filtration of the blood. A new platform
Abhigyan Satyam, Maria G Tsokos, Di Zeugolis   +2 more
exaly   +2 more sources

PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy

Cell Death and Disease, 2019
Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic nephropathy (DN). Therapeutic strategies targeting mitochondrial dysfunction hold considerable promise for the treatment of DN.
Ziying Wang, Xiaojie Wang, Yu Sun
exaly   +2 more sources

3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening

Nature Communications, 2018
The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming interdigitating foot processes with intervening slit diaphragms, disruption in which results in proteinuria.
Lorna J Hale, Sara E Howden, Belinda Phipson   +2 more
exaly   +2 more sources

Ferroptosis in Podocytes: An Emerging Focus in Kidney Diseases [PDF]

Biology
Ferroptosis is a mechanism of programmed cell death that is characterized by iron-dependent lipid peroxidation, and it is closely associated with organismal metabolism.
Jun Feng, Yiqiong Ma, Chunyun Zhang
doaj   +2 more sources