Results 91 to 100 of about 47,146 (309)

Effects of Self-Made Prescription Compound Rhodiola on the Ultrastructure of Podocytes in Rats with Type 2 Diabetic Nephropathy

Emergency Medicine International, 2022
Background. We attempt to discuss the function of self-made prescription compound Rhodiola rosea on the kidneys of rats with type 2 diabetic nephropathy (DN), through studying the effects of self-made rescription compound Rhodiola rosea on the ...
Shaojing Yuan, Jie Liu, Zhenhua Sun, Lihua Meng, Jiying Zhu, Min Wang, Jie Su   +6 more
doaj   +1 more source

Seasonal relapsing minimal change disease: a novel strategy for avoiding long-term immunosuppression. [PDF]

, 2012
BACKGROUND: We describe the case of a young woman with seasonal allergic rhinitis who presented with signs of a lower respiratory tract infection, acute renal impairment and the nephrotic syndrome, demonstrated on biopsy to be due to minimal change ...
Cook, HT, Lawrence, C, Lightstone, L
core   +2 more sources

Resident Macrophage‐Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor‐Associated Nephrotoxicity

Advanced Science, EarlyView.
Schematic illustration of resident macrophages in Immune checkpoint inhibitor‐associated nephrotoxicity (ICI‐AN). Using an integrated approach (including imaging mass cytometry, transcriptomics, and murine models), this study reveals that resident macrophages drive immune‐stromal interactions in ICI‐AN, promoting fibroblast activation through CXCL9 and
Yanhong Ma, Yang Chen, Qinfan Yao, Yuxi Wang, Nan Ouyang, Fei Han, Guzong Wang, Meifang Wang, Yuan Yuan, Jianghua Chen, Jianzhen Shan, Dajin Chen   +11 more
wiley   +1 more source

Notoginsenoside R1 Ameliorates Podocyte Adhesion Under Diabetic Condition Through α3β1 Integrin Upregulation in Vitro and in Vivo

Cellular Physiology and Biochemistry, 2014
Background: Decreased expression of α3β1 integrin may contribute to reduction in podocyte adhesion to glomerular basement membrane (GBM), which represents a novel early mechanism leading to diabetic kidney disease (DKD).
Dingkun Gui, Li Wei, Guihua Jian, Yongping Guo, Jiajun Yang, Niansong Wang   +5 more
doaj   +1 more source

C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation [PDF]

, 2019
Hypertrophy is a prominent feature of damaged podocytes in diabetic kidney disease (DKD). mTORC1 hyperactivation leads to podocyte hypertrophy, but the detailed mechanism of how mTORC1 activation occurs under pathological conditions is not completely ...
Ha, Tae-Sun, Jeong, Heeyoon, Kim, Eui, Koh, Ara, Lee, Jiyoun, Ryu, Sung Ho, Saleem, Moin A.   +6 more
core   +1 more source

The Role of the Podocyte in Preeclampsia [PDF]

Clinical Journal of the American Society of Nephrology, 2014
Preeclampsia is a pregnancy-specific hypertensive disorder that affects approximately 5% of pregnancies and remains one of the leading causes of both maternal and fetal morbidity and mortality worldwide ([1][1]).
openaire   +3 more sources

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA

Advanced Science, EarlyView.
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li, Julian Aurelio Marschner, Yoshihiro Kusunoki, Ningxin Zhang, Xiaoxin Li, Hao Deng, Zhibo Zhao, Kanako Watanabe‐Kusunoki, Zhihui Zhu, Yan Xu, Stefanie Steiger, Maciej Lech, Katalin Susztak, Christian Schulz, Hans‐Joachim Anders   +14 more
wiley   +1 more source

MicroRNAs in Podocyte Injury in Diabetic Nephropathy

Frontiers in Genetics, 2020
Diabetic nephropathy is one of the major complications of diabetes mellitus and is the leading cause of end-stage renal disease worldwide. Podocyte injury contributes to the development of diabetic nephropathy.
Hiroki Ishii, Shohei Kaneko, Katsunori Yanai, Akinori Aomatsu, Keiji Hirai, Susumu Ookawara, Kenichi Ishibashi, Yoshiyuki Morishita   +7 more
doaj   +1 more source

Is it or is it not a pathogenic mutation? Is it or is it not the podocyte? [PDF]

Journal of Nephropathology, 2012
Fabry disease is caused by a deficient activity of alpha-galactosidase A (α-GalA) due to mutations in the X chromosome GLA gene. The enzymatic defect causes intracellular accumulation of neutral glycosphingolipids, mainly globotriaosylceramide (GL-3), as well as increased circulating levels of globotriaosylsphingosine (Lyso-GL-3) (1).
Alberto Ortiz, Sánchez-Niño
openaire   +4 more sources

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

Advanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu, Hong Zhang, Shanzhi Yang, Jiaoqing Li, Danfeng Wu, Haosen Xu, Huan Jiang, Yi Jing, Guoxiang Jin, Ruobing Liu, Ning Fan, Xiaoyan Bai   +11 more
wiley   +1 more source