Results 101 to 110 of about 48,174 (296)

Deficiency of Nuclear Receptor Coactivator 3 Aggravates Diabetic Kidney Disease by Impairing Podocyte Autophagy

Advanced Science
Nuclear receptors (NRs) are important transcriptional factors that mediate autophagy, preventing podocyte injury and the progression of diabetic kidney disease (DKD).
Yaru Xie, Qian Yuan, Xinyi Cao, Yang Qiu, Jieyu Zeng, Yiling Cao, Yajuan Xie, Xianfang Meng, Kun Huang, Fan Yi, Chun Zhang   +10 more
doaj   +1 more source

Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition

iScience
Summary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes is ...
Jennifer A. Hurcombe, Fern Barrington, Micol Marchetti, Virginie M.S. Betin, Emily E. Bowen, Abigail C. Lay, Lan Ni, Lusyan Dayalan, Robert J.P. Pope, Paul T. Brinkkoetter, Martin Holzenberger, Gavin I. Welsh, Richard J.M. Coward   +12 more
doaj   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists, Sodium‐Glucose Cotransporter‐2 Inhibitors, and Risk of Autoimmune Rheumatic Diseases

Arthritis &Rheumatology, Accepted Article.
Objective GLP‐1 receptor agonists (GLP‐1RAs) and SGLT2 inhibitors (SGLT2is) facilitate weight loss and exhibit immunomodulatory effects, but their impact on the risk of developing autoimmune rheumatic diseases (ARDs) is unclear. We compared ARD incidence following initiation of GLP‐1RAs, or SGLT2is, vs.
Derin Karacabeyli, Diane Lacaille, Na Lu, Hui Xie, J. Antonio Aviña‐Zubieta   +4 more
wiley   +1 more source

5‐Methylcytosine Analysis of miRNAs in Minimal Change Disease

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Minimal change disease (MCD) is a glomerular disorder, which is the most common cause of nephrotic syndrome in children. Additionally, the prevalence of MCD in adults has been increasing in recent years. During protein synthesis, noncoding RNAs can be regulated through a variety of modifications, which helps preserve biological diversity and ...
Huiyi Zeng, Dandan Li, Yunyi Li, Chen Yun, Xinzhou Zhang, Wenyu Gong, Mengyun Xiao, Haitao Li, Zhipeng Zeng, Ruqi Tan, Yishen Yang, Shaodong Luan, Yong Dai, Lianghong Yin, Donge Tang   +14 more
wiley   +1 more source

15th International Podocyte Conference, Hamburg, Germany, June 11-13, 2025. Abstracts: From Glomerular Biology to Glomerular Medicine

Glomerular Diseases
Over the past decades, the trajectory of podocyte biology and glomerular medicine has evolved into a globally connected, interdisciplinary field at the interface of cell biology, systems medicine, and clinical nephrology.
Laurel Damashek
doaj   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Tmem30a protects against podocyte injury through suppression of pyroptosis

iScience
Summary: Podocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized by podocyte injury and can easily progress to end-stage kidney disease. However, the mechanisms underlying podocyte injury remain unclear. We observed podocyte
Yanpei Hou, Sipei Chen, Lei Peng, Liming Huang, Huijian Zhang, Ping Zhang, Min Yu, Lin Xiong, Xiang Zhong, Wenjing Liu, Xianjun Zhu, Li Wang, Yi Li, Guisen Li   +13 more
doaj   +1 more source

mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans.

JCI Insight, 2019
The cellular origins of glomerulosclerosis involve activation of parietal epithelial cells (PECs) and progressive podocyte depletion. While mammalian target of rapamycin-mediated (mTOR-mediated) podocyte hypertrophy is recognized as an important ...
Victor G. Puelles, J. W. van der Wolde, Nicola Wanner, M. Scheppach, L. Cullen-McEwen, Tillmann Bork, M. Lindenmeyer, Lukas Gernhold, M. N. Wong, Fabian Braun, C. Cohen, M. Kett, C. Kuppe, R. Kramann, Turgay Saritas, C. V. van Roeyen, M. Moeller, L. Tribolet, R. Rebello, Y. B. Sun, Jinhua Li, G. Müller-Newen, M. Hughson, W. Hoy, F. Person, T. Wiech, S. Ricardo, P. Kerr, K. Denton, L. Furic, T. Huber, D. Nikolic-Paterson, J. Bertram   +32 more
semanticscholar   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Exosomal microRNA‐16‐5p from human urine‐derived stem cells ameliorates diabetic nephropathy through protection of podocyte

Journal of Cellular and Molecular Medicine, 2019
Diabetic nephropathy (DN) remains one of the severe complications associated with diabetes mellitus. It is worthwhile to uncover the underlying mechanisms of clinical benefits of human urine‐derived stem cells (hUSCs) in the treatment of DN.
Y. Duan, Bao-ping Chen, Fang Chen, Suxia Yang, Chaoyang Zhu, Yali Ma, Yang Li, Jun Shi   +7 more
semanticscholar   +1 more source