Results 171 to 180 of about 47,146 (309)

Podocyte injury underlies the progression of focal segmental glomerulosclerosis in the fa/fa Zucker rat [PDF]

open access: bronze, 2001
Nikolaus Gaßler   +7 more
openalex   +1 more source

Tubular Injury in Diabetic Kidney Disease: Early Diagnosis and Intervention Strategies

open access: yesDiabetes/Metabolism Research and Reviews, Volume 41, Issue 7, October 2025.
ABSTRACT Diabetic kidney disease (DKD) is the most severe complication of diabetes mellitus and has poor prognosis, often progressing to end‐stage renal disease, causing substantial morbidity and mortality globally. While the pathogenesis of DKD has been extensively characterised, including glomerular hyperfiltration, podocyte injury, and ...
Yi Lv   +7 more
wiley   +1 more source

Multi‐Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review

open access: yesFood Science &Nutrition, Volume 13, Issue 10, October 2025.
This review shows evidence from preclinical and clinical studies, supporting the therapeutic potential of polyphenols for diabetic kidney disease (DKD). This is due to their diverse bioactive properties and ability to intervene in intricate mechanisms of the disease.
Esienanwan E. Efiong   +10 more
wiley   +1 more source

Selected miRNAs in Urinary Extracellular Vesicles Show Promise for Early and Specific Diagnostics of Diabetic Kidney Disease

open access: yesJournal of Extracellular Biology, Volume 4, Issue 10, October 2025.
Abstract Diabetic kidney disease (DKD) is a health burden that lacks specific and early diagnostic biomarkers. For their discovery, we sequenced urinary extracellular vesicle miRNAs in a type 1 diabetes cohort of males with and without DKD. The results were replicated by sequencing or qPCR in two independent cohorts and six published datasets ...
Karina Barreiro   +14 more
wiley   +1 more source

Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies

open access: bronze, 2000
Laura Barisoni   +5 more
openalex   +1 more source

[Podocyte dysfunction and proteinuria].

open access: yesNederlands tijdschrift voor geneeskunde, 2004
Podocytes play a central role in the pathogenesis of several glomerular diseases. In recent years, this has been revealed by molecular analysis of a number of rare hereditary renal diseases. Podocytes contain three domains: the domain bound to the glomerular basement membrane (GBM), the domain of the slit diaphragms and the apical domain.
Vogtländer, N.P.J.   +3 more
openaire   +3 more sources

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 6, Issue 10, October 2025.
This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin   +15 more
wiley   +1 more source

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