Results 171 to 180 of about 47,146 (309)
Podocyte injury underlies the progression of focal segmental glomerulosclerosis in the fa/fa Zucker rat [PDF]
Nikolaus Gaßler +7 more
openalex +1 more source
Collapsing glomerulopathy: A 30-year perspective and single, large center experience [PDF]
Cossey, Nicholas +2 more
core +2 more sources
Tubular Injury in Diabetic Kidney Disease: Early Diagnosis and Intervention Strategies
ABSTRACT Diabetic kidney disease (DKD) is the most severe complication of diabetes mellitus and has poor prognosis, often progressing to end‐stage renal disease, causing substantial morbidity and mortality globally. While the pathogenesis of DKD has been extensively characterised, including glomerular hyperfiltration, podocyte injury, and ...
Yi Lv +7 more
wiley +1 more source
This review shows evidence from preclinical and clinical studies, supporting the therapeutic potential of polyphenols for diabetic kidney disease (DKD). This is due to their diverse bioactive properties and ability to intervene in intricate mechanisms of the disease.
Esienanwan E. Efiong +10 more
wiley +1 more source
Abstract Diabetic kidney disease (DKD) is a health burden that lacks specific and early diagnostic biomarkers. For their discovery, we sequenced urinary extracellular vesicle miRNAs in a type 1 diabetes cohort of males with and without DKD. The results were replicated by sequencing or qPCR in two independent cohorts and six published datasets ...
Karina Barreiro +14 more
wiley +1 more source
Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies
Laura Barisoni +5 more
openalex +1 more source
[Podocyte dysfunction and proteinuria].
Podocytes play a central role in the pathogenesis of several glomerular diseases. In recent years, this has been revealed by molecular analysis of a number of rare hereditary renal diseases. Podocytes contain three domains: the domain bound to the glomerular basement membrane (GBM), the domain of the slit diaphragms and the apical domain.
Vogtländer, N.P.J. +3 more
openaire +3 more sources
This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin +15 more
wiley +1 more source

