Results 11 to 20 of about 47,146 (309)
F1000Research, 2016 Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries and that neighbor cells of the Bowman’s capsule. When it comes to glomerular filtration, podocytes play an active role in preventing plasma proteins from entering the urinary ultrafiltrate by providing a barrier comprising filtration slits between foot ...
Jochen Reiser, Mehmet M. Altintas
openaire +4 more sources
Endothelin and the podocyte [PDF]
Clinical Kidney Journal, 2012 In the past decade, research has advanced our understanding how endothelin contributes to proteinuria and glomerulosclerosis. Data from pre-clinical and clinical studies now provide evidence that proteinuric diseases such as focal segmental glomerulosclerosis and diabetic nephropathy as well as hypertension nephropathy are sensitive to treatment with ...
Matthias Barton, Pierre-Louis Tharaux
openaire +3 more sources
Kidney International, 2009 Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocytes, including the nephrin-based slit
Simons, Matias, Huber, Tobias B.
openaire +3 more sources
Podocyte Injury Damages Other Podocytes [PDF]
Journal of the American Society of Nephrology, 2011 Loss of podocytes promotes glomerulosclerosis, but whether this results from a continued primary insult or a secondary mechanism triggered by the initial loss of podocytes is unknown. We generated chimeric mice in which only a subpopulation of podocytes expressed hCD25, which is the receptor for the immunotoxin LMB2.
Taiji Matsusaka +6 more
openaire +3 more sources
Frontiers in Pharmacology, 2021 Background: Podocyte injury has a direct causal relationship with proteinuria and glomerulosclerosis and, on a chronic level, can lead to irreversible disease progression. Podocyte injury plays a critically decisive role in the development of proteinuric
Tongtong Liu +5 more
doaj +1 more source
Urinary Podocyte Excretion Predicts Urinary Protein Selectivity and Renal Prognosis
International Journal of Nephrology, 2022 Background. Urinary podocyte excretion is related to a reduction in glomerular podocyte numbers, glomerulosclerosis, and urinary protein selectivity.
Makoto Abe +4 more
doaj +1 more source
Podocyte Biology and the Emerging Understanding of Podocyte Diseases [PDF]
American Journal of Nephrology, 2003 The understanding of the unique molecular apparatus of the podocyte has increased dramatically in recent years. This new knowledge has improved the diagnosis and classification of the diseases that have been termed podocytopathies. Podocyte injury frequently leads to reorganization of the slit diaphragm and reorganization of the foot process structure.
Laura Barisoni, Peter Mundel
openaire +3 more sources
Podocyte Mitosis - A Catastrophe [PDF]
Current Molecular Medicine, 2012 Podocyte loss plays a key role in the progression of glomerular disorders towards glomerulosclerosis and chronic kidney disease. Podocytes form unique cytoplasmic extensions, foot processes, which attach to the outer surface of the glomerular basement membrane and interdigitate with neighboring podocytes to form the slit diaphragm.
LASAGNI, LAURA +4 more
openaire +4 more sources
Cell Death and Disease, 2022 A major cause of proteinuria in lupus nephritis (LN) is podocyte injury, and determining potential therapeutic targets to prevent podocyte injury is important from a clinical perspective in the treatment of LN.
Fu Lv +9 more
doaj +1 more source
Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
Journal of Diabetes Research, 2020 Diabetic nephropathy (DN) is not only an important microvascular complication of diabetes but also the main cause of end-stage renal disease. Studies have shown that the occurrence and development of DN are closely related to morphological and functional
Lili Zhang +9 more
doaj +1 more source