Results 11 to 20 of about 48,174 (296)

Podocytes [PDF]

F1000Research, 2016
Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries and that neighbor cells of the Bowman’s capsule. When it comes to glomerular filtration, podocytes play an active role in preventing plasma proteins from entering the urinary ultrafiltrate by providing a barrier comprising filtration slits between foot ...
Jochen Reiser, Mehmet M. Altintas
openaire   +4 more sources

Morin Alleviates Fructose-Driven Disturbance of Podocyte Mitochondrial Energy Metabolism by Inhibiting Adenosine 5′-Monophosphate Deaminase Activity to Improve Glomerular Injury [PDF]

Pharmaceuticals
Background/Objectives: High fructose consumption is a significant risk factor for glomerular podocyte injury. This study aimed to identify the underlying mechanism of fructose-induced podocyte injury and explore the protective effect of the natural ...
Yingzhi Yang, Ziyan Wan, Luyi Huang, Ziang Zhou, Wanru Wang, Yu Xing, Shijie Li, Yufan Du, Jiufang Huang, Yanqing Wu, Mengyu Fan, Jiahuang Li, Lingdong Kong, Dongmei Zhang   +13 more
doaj   +2 more sources

Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy

Journal of Diabetes Research, 2017
Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases.
Qingquan Liu, Baoli Liu
exaly   +2 more sources

Silencing of long noncoding RNA PVT1 inhibits podocyte damage and apoptosis in diabetic nephropathy by upregulating FOXA1

Experimental and Molecular Medicine, 2019
The number of patients with diabetic nephropathy (DN) is still on the rise worldwide, and this requires the development of new therapeutic strategies. Recent reports have highlighted genetic factors in the treatment of DN.
Dongwei Liu, Jiahui Zhang, Fengxun Liu, Xutong Wang, S. Pan, Deng-Ke Jiang, Zihao Zhao, Zhangsuo Liu   +7 more
exaly   +2 more sources

FGF4-FGFR1 signaling promotes podocyte survival and glomerular function to ameliorate diabetic kidney disease in male mice [PDF]

Nature Communications
Podocyte injury is central to diabetic kidney disease (DKD) pathogenesis, however, the mechanisms underlying podocyte loss remain unclear. Emerging evidence underscores the involvement of fibroblast growth factors (FGFs) in renal pathophysiology. Here we
Jie Zhou, Shuxin Wang, Jiaxin Lou, Beibin Pan, Min Zhao, Qian Li, Jing Zhou, Yali Du, Shuodan Ding, Meiling Yu, Jingjing Zhou, Xinwei Chen, Lingwei Jin, Xinyi Wang, Yepeng Hu, Zhe Wang, Xiaokun Li, Chao Zheng, Jian Sun, Zhifeng Huang   +19 more
doaj   +2 more sources

Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy

Acta Pharmacologica Sinica, 2020
Qian Cheng, Fan Yin, Wei Zhang
exaly   +2 more sources

Podocyte Injury in Diabetic Kidney Disease in Mouse Models Involves TRPC6-mediated Calpain Activation Impairing Autophagy

Journal of the American Society of Nephrology, 2023
Visual Abstract Significance Statement Autophagy protects podocytes from injury in diabetic kidney disease (DKD). Restoring glomerular autophagy is a promising approach to limit DKD.
Yann Salemkour, Dilemin Yildiz, L. Dionet, Daan C. ‘t Hart, Kim A T Verheijden, Ryuta Saito, Nassim Mahtal, J. Delbet, Emmanuel Letavernier, Marion Rabant, Alexandre Karras, J. van der Vlag, Tom Nijenhuis, P. Tharaux, O. Lenoir   +14 more
semanticscholar   +1 more source

Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy

Autophagy, 2022
Podocyte injury leading to albuminuria is a characteristic feature of diabetic nephropathy (DN). Hyperglycemia and advanced glycation end products (AGEs) are major determinants of DN.
F. Barutta, S. Bellini, S. Kimura, K. Hase, B. Corbetta, A. Corbelli, F. Fiordaliso, S. Bruno, L. Biancone, A. Barreca, M. Papotti, E. Hirsh, M. Martini, R. Gambino, M. Durazzo, H. Ohno, G. Gruden   +16 more
semanticscholar   +1 more source

Age-related GSK3β overexpression drives podocyte senescence and glomerular aging

Journal of Clinical Investigation, 2022
As life expectancy continues to increase, clinicians are challenged by age-related renal impairment that involves podocyte senescence and glomerulosclerosis.
Yudong Fang, Bohan Chen, Zhangsuo Liu, Athena Y. Gong, W. Gunning, Y. Ge, Deepak Malhotra, A. Gohara, L. Dworkin, R. Gong   +9 more
semanticscholar   +1 more source

Podocyte Injury Damages Other Podocytes [PDF]

Journal of the American Society of Nephrology, 2011
Loss of podocytes promotes glomerulosclerosis, but whether this results from a continued primary insult or a secondary mechanism triggered by the initial loss of podocytes is unknown. We generated chimeric mice in which only a subpopulation of podocytes expressed hCD25, which is the receptor for the immunotoxin LMB2.
Taiji, Matsusaka, Eric, Sandgren, Ayumi, Shintani, Valentina, Kon, Ira, Pastan, Agnes B, Fogo, Iekuni, Ichikawa   +6 more
openaire   +2 more sources