Results 21 to 30 of about 47,146 (309)
Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]
, 2011 Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core +1 more source
The American Journal of Pathology, 2013 This Commentary highlights the article by Pippin et al that showed that renin lineage cells may enhance glomerular regeneration by serving as progenitors for glomerular epithelial cells in glomerular disease characterized by podocyte depletion.
Florian Grahammer +4 more
openaire +4 more sources
Podocyte Depletion in Thin GBM and Alport Syndrome.
PLoS ONE, 2016 The proximate genetic cause of both Thin GBM and Alport Syndrome (AS) is abnormal α3, 4 and 5 collagen IV chains resulting in abnormal glomerular basement membrane (GBM) structure/function. We previously reported that podocyte detachment rate measured in
Larysa Wickman +5 more
doaj +1 more source
Tracking the stochastic fate of cells of the renin lineage after podocyte depletion using multicolor reporters and intravital imaging. [PDF]
PLoS ONE, 2017 Podocyte depletion plays a major role in focal segmental glomerular sclerosis (FSGS). Because cells of the renin lineage (CoRL) serve as adult podocyte and parietal epithelial cell (PEC) progenitor candidates, we generated Ren1cCre/R26R-ConfettiTG/WT and
Natalya V Kaverina +9 more
doaj +1 more source
Podocyte Lipotoxicity in CKD [PDF]
Kidney360, 2021 CKD represents the ninth most common cause of death in the United States but, despite this large health burden, treatment options for affected patients remain limited. To remedy this, several relevant pathways have been identified that may lead to novel therapeutic options.
Sydney S. Wilbon +2 more
openaire +3 more sources
Angiopoietin-Like-4, a Potential Target of Tacrolimus, Predicts Earlier Podocyte Injury in Minimal Change Disease. [PDF]
PLoS ONE, 2015 Podocyte injury plays central roles in proteinuria and kidney dysfunction, therefore, identifying specific biomarker to evaluate earlier podocyte injury is highly desirable.
Jian-Si Li +10 more
doaj +1 more source
A new outlook towards kidney injuries [PDF]
, 2012 Acute and chronic progression of injury to the kidney leads to the failure of the renal system and has become an increasingly important cause of morbidity and mortality.
Abhijeet Satwekar, Mahesh Satwekar
core +2 more sources
The Role of Palladin in Podocytes [PDF]
Journal of the American Society of Nephrology, 2018 Background Podocyte loss and effacement of interdigitating podocyte foot processes are the major cause of a leaky filtration barrier and ESRD. Because the complex three-dimensional morphology of podocytes depends on the actin cytoskeleton, we studied the role in podocytes of the actin bundling protein palladin, which is ...
Marie Louise Bang +14 more
openaire +5 more sources
Cdk5 Contributes to Diabetic Islet β Cell and Kidney Injury by Impairing Autophagy. [PDF]
FASEB JOver‐activation of cyclin‐dependent kinase 5 (Cdk5) is involved in the development of diabetes and its complications. Mechanistically, Cdk5 expression was upregulated in diabetic mice, which induced attenuated autophagy and increased apoptosis of islet β cells, as well as decreased insulin secretion.
Tao Y +8 more
europepmc +2 more sources
CXCL16 and oxLDL are induced in the onset of diabetic nephropathy [PDF]
, 2009 Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients with ...
Abdel-Aziz, Abdel-Aziz H. +11 more
core +1 more source