Results 21 to 30 of about 48,174 (296)

Podocyte Injury in Diabetic Kidney Disease: A Focus on Mitochondrial Dysfunction

Frontiers in Cell and Developmental Biology, 2022
Podocytes are a crucial cellular component in maintaining the glomerular filtration barrier, and their injury is the major determinant in the development of albuminuria and diabetic kidney disease (DKD).
Simeng Liu, Yanggang Yuan, Yi Xue, C. Xing, Bo Zhang   +4 more
semanticscholar   +1 more source

YAP Translocation Precedes Cytoskeletal Rearrangement in Podocyte Stress Response: A Podometric Investigation of Diabetic Nephropathy

Frontiers in Physiology, 2021
Podocyte loss plays a pivotal role in the pathogenesis of glomerular disease. However, the mechanisms underlying podocyte damage and loss remain poorly understood.
Kathryn E. Haley, Kathryn E. Haley, Mustafa Elshani, Mustafa Elshani, In Hwa Um, Cameron Bell, Cameron Bell, Peter D. Caie, David J. Harrison, David J. Harrison, Paul A. Reynolds, Paul A. Reynolds   +11 more
doaj   +1 more source

Abnormal Crosstalk between Endothelial Cells and Podocytes Mediates Tyrosine Kinase Inhibitor (TKI)-Induced Nephrotoxicity

Cells, 2021
Vascular endothelial growth factor A (VEGFA) and its receptor VEGFR2 are the main targets of antiangiogenic therapies, and proteinuria is one of the common adverse events associated with the inhibition of the VEGFA/VEGFR2 pathway.
Xiaoying Gu, Su Zhang, Ti Zhang
doaj   +1 more source

METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1

Cell Death and Disease, 2021
Podocytes are known to play a determining role in the progression of proteinuric kidney disease. N6-methyladenosine (m6A), as the most abundant chemical modification in eukaryotic mRNA, has been reported to participate in various pathological processes ...
Zhihui Lu, Hong Liu, Nana Song, Yiran Liang, Jia-ming Zhu, Jing Chen, Yi-chun Ning, Jiachang Hu, Yi Fang, J. Teng, Jianzhou Zou, Yan Dai, Xiaoqiang Ding   +12 more
semanticscholar   +1 more source

Flying podocytes [PDF]

Kidney International, 2009
Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocytes, including the nephrin-based slit
Simons, Matias, Huber, Tobias B.
openaire   +3 more sources

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

Genes and Diseases, 2022
Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen, Chunhua Weng, Yucheng Wang, Cuili Wang, Shi Feng, Xiayu Li, Heng Li, Hong Jiang, Haibing Wang, Jianghua Chen   +9 more
doaj   +1 more source

Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling

Frontiers in Pharmacology, 2021
Background: The total flavones of Abelmoschus manihot (TFA), a compound that is extracted from Abelmoschus manihot, has been widely used in China to reduce podocyte injury in diabetic kidney disease (DKD).
Buhui Liu, Y. Tu, Guang-xia Ni, Jin Yan, Li-Jun Yue, Zida Li, Jingging Wu, Yu-Ting Cao, Z. Wan, Wei Sun, Y. Wan   +10 more
semanticscholar   +1 more source

Increasing urinary podocyte mRNA excretion and progressive podocyte loss in kidney contribute to the high risk of long-term renal disease caused by preterm birth

Scientific Reports, 2021
Podocyte abnormalities are common mechanism driving the progression of glomerular diseases, which account for most chronic kidney diseases (CKDs). However, the role of podocyte in the mechanism of high-risk long-term CKD caused by prematurity has not ...
Fangrui Ding, Qi Gao, Xiuying Tian, Jiali Mo, Jun Zheng   +4 more
doaj   +1 more source

SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome Activation

Kidney Diseases, 2021
Background: Podocyte injury contributes to progressive glomerulosclerosis. Previously, we demonstrated the important role of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in mediating the podocyte injury induced by aldosterone.
Mingzhu Jiang, Min Zhao, Mi Bai, Juan Lei, Yanggang Yuan, Songming Huang, Yue Zhang, Guixia Ding, Zhanjun Jia, Aihua Zhang   +9 more
doaj   +1 more source

Quercetin Attenuates Podocyte Apoptosis of Diabetic Nephropathy Through Targeting EGFR Signaling

Frontiers in Pharmacology, 2022
Podocytes injury is one of the leading causes of proteinuria in patients with diabetic nephropathy (DN), and is accompanied by podocytes apoptosis and the reduction of podocyte markers such as synaptopodin and nephrin.
Yi-qi Liu, Yuan Li, Liu Xu, Jia-yu Shi, Xiujuan Yu, Xue Wang, Xi-zhi Li, Hong Jiang, Tingting Yang, Xiaoxin Yin, Lei Du, Q. Lu   +11 more
semanticscholar   +1 more source