Results 31 to 40 of about 47,146 (309)
BMC Nephrology, 2006 Background A reduction in the number of podocytes and podocyte density has been documented in the kidneys of patients with diabetes mellitus. Additional studies have shown that podocyte injury and loss occurs in both diabetic animals and humans. However,
Sullivan Kelli A +4 more
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Frontiers in Pharmacology, 2022 Podocytes form a key component of the glomerular filtration barrier. Damage to podocytes is referred to as “podocyte disease.” There are many causes of podocyte injury, including primary injury, secondary injury, and gene mutations.
Lirong Lin +5 more
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The podocyte and the proteoglycan [PDF]
American Journal of Physiology-Renal Physiology, 2016 proteoglycans (PGs) consist of a core protein and linear sugar side chains [glycosaminoglycans (GAGs)] attached to the core protein, e.g., agrin, perlecan, glypican, and syndecan. GAGs comprise repeating duplex sugar units made of an aminosugar (e.g., N -acetylglucosamine or N -acetylgalactosamine)
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Role of the podocyte in proteinuria [PDF]
Pediatric Nephrology, 2011 In recent years, the podocyte, with its elaborate cytoarchitecture and slit diaphragm, has been the focus of extensive research, yet its precise role in the glomerular filtration barrier is still debated. There are puzzling observations indicating that a comprehensive mechanistic model for glomerular filtration is still necessary.
Marcus J. Moeller, Sylvia Menzel
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Whole carcass diets: a role for fibre in gastrointestinal health of cheetahs? [PDF]
, 2011 This study was undertaken to test the hypothesis that altered podocyte slit protein nephrin distribution is associated with disturbed polarity protein expressions in podocytes from preeclampsia (PE).
Depauw, Sarah +6 more
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Journal of Clinical Investigation, 2011 The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental ...
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Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry disease. [PDF]
PLoS ONE, 2011 Injury to the glomerular podocyte is a key mechanism in human glomerular disease and podocyte repair is an important therapeutic target. In Fabry disease, podocyte injury is caused by the intracellular accumulation of globotriaosylceramide.
Thaneas Prabakaran +8 more
doaj +1 more source
Engineered RGD-Treg-Exos Targeted Delivery of miR-218-5p to Activate Mitophagy and Attenuate Podocyte Injury in Diabetic Kidney Disease. [PDF]
Adv Sci (Weinh)Tregs‐Exos deliver miR‐218‐5p to increase mitophagy in podocytes by inhibiting the TNC/TLR4/SRC/FUNDC1 pathway. RGD‐Treg‐Exos, engineered to express RGD peptides on the membrane surface, bind to integrins on the surface of podocytes and effectively target podocytes for the delivery of miR‐218‐5p, which increases mitophagy and reduces apoptosis in ...
Guo Z +11 more
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Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease. [PDF]
, 2014 The renin-angiotensin system (RAS), bone morphogenetic protein (BMP), and WNT pathways are involved in pathogenesis of diabetic kidney disease (DKD).
Afkarian, Maryam +5 more
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Insulin in podocyte podiatry [PDF]
Journal of Diabetes Investigation, 2011 Diabetic nephropathy, a major complication of diabetes mellitus, is the leading cause of end‐stage renal disease worldwide and recently it has been recognized as a high risk for the development of cardiovascular disease. Clinical features of diabetic nephropathy are development of albuminuria followed by persistent proteinuria and, later, reduction of ...
Yuichi Makino, Masakazu Haneda
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