Eluate derived by extracorporal antibody-based immunoadsorption elevates the cytosolic Ca2+ concentration in podocytes via B-2 kinin receptors [PDF]
, 2002 Background/Aim: Patients with idiopathic focal segmental glomerulosclerosis (FSGS) often develop a recurrence of the disease after kidney transplantation.
Fink, E. +6 more
core +1 more source
Journal of Advanced ResearchIntroduction: Podocyte senescence causes podocyte loss and glomerulopathy. Excessive fructose intake is a risk factor for podocyte injury. However, whether high fructose promotes podocyte senescence remains unknown.
Li Chen +5 more
doaj +1 more source
The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease
Kidney Diseases, 2021 Background: Podocytes, functionally specialized and terminally differentiated glomerular visceral epithelial cells, are critical for maintaining the structure and function of the glomerular filtration barrier.
Yu Sun, Sijia Cui, Yunfeng Hou, Fan Yi
doaj +1 more source
A Novel Role of Neutrophil Elastase in Podocyte Dysfunction Induced by High Glucose, PMA, and MDP [PDF]
J Cell PhysiolPodocyte injury occurs as a result of neutrophil elastase activity, a process in which NOD2 plays a contributing role. ABSTRACT Podocytes are not only the key regulators of glomerular filtration barrier dynamics but also exhibit immunological properties.
Kulesza T +9 more
europepmc +2 more sources
Chemical composition, antioxidant and alpha-Glucosidase-Inhibiting activities of the aqueous and hydroethanolic extracts of Vaccinium myrtillus Leaves [PDF]
, 2017 Vaccinium myrtillus (bilberry) leaf is traditionally used in southeastern Europe for the treatment of diabetes. In the present study, the ability of bilberry leaf extracts to inhibit carbohydrate-hydrolyzing enzymes and restore glutathione concentration ...
Bljajic, Kristina +7 more
core +1 more source
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
core +1 more source
Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury.
PLoS ONE, 2014 Podocyte injury is the first step in the progression of glomerulosclerosis. Previous studies have demonstrated the beneficial effect of bone morphogenetic protein 7 (Bmp7) in podocyte injury and the existence of native Bmp signaling in podocytes.
Sachiko Yamada +19 more
doaj +1 more source
Role of miRNA-671-5p in Mediating Wnt/β-Catenin-Triggered Podocyte Injury
Frontiers in Pharmacology, 2022 Podocyte injury and proteinuria are the most common features of glomerular disease, which is the leading cause of end-stage renal failure. Hyperactivated Wnt/β-catenin signaling is closely associated with podocyte injury, but the underlying mechanisms ...
Chunhong Wang +8 more
doaj +1 more source
Activation of podocyte Notch mediates early Wt1 glomerulopathy [PDF]
, 2018 The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of ...
Alex K. Virasami +58 more
core +1 more source
Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment. [PDF]
PLoS ONE, 2014 Glomerular diseases are commonly characterized by podocyte injury including apoptosis, actin cytoskeleton rearrangement and detachment. However, the strategies for preventing podocyte damage remain insufficient.
Yu-Lin Kang +4 more
doaj +1 more source