Results 31 to 40 of about 48,174 (296)

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction

Cell Death and Disease, 2022
Podocyte damage mediated by in situ complement activation in the glomeruli is a key factor in the pathogenesis of membranous nephropathy (MN), but the molecular mechanism has not been fully elucidated.
Hui Wang, Daoyuan Lv, Song Jiang, Q. Hou, Lei Zhang, Shen Li, Xiaodong Zhu, Xiaodong Xu, Jianqiang Wen, C. Zeng, Mingchao Zhang, Fan Yang, Zhaohong Chen, C. Zheng, Jing Li, Ke Zen, Zhihong Liu, Limin Li   +17 more
semanticscholar   +1 more source

PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment

Renal Failure, 2023
Podocytes play a critical role in maintaining normal glomerular filtration, and podocyte loss from the glomerular basement membrane (GBM) initiates and worsens chronic kidney disease (CKD).
Xiaoxiao Huang, Zhaowei Chen, Zilv Luo, Yiqun Hao, Jun Feng, Zijing Zhu, Xueyan Yang, Zongwei Zhang, Jijia Hu, Wei Liang, Guohua Ding   +10 more
doaj   +1 more source

GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity

Theranostics, 2021
Rationale: Albuminuria is an early clinical feature in the progression of diabetic nephropathy (DN). Podocyte insulin resistance is a main cause of podocyte injury, playing crucial roles by contributing to albuminuria in early DN.
Jian Lu, Pei-pei Chen, Jia Xiu Zhang, X. Li, G. Wang, B. Yuan, Si-jia Huang, X. Liu, Ting-Ting Jiang, Meng Ying Wang, W. T. Liu, X. Ruan, B. C. Liu, K. Ma   +13 more
semanticscholar   +1 more source

Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis

Arthritis and Rheumatology, 2017
Yuefang Huang, Jijun Zhao, Sun-Sang J Sung   +2 more
exaly   +2 more sources

Urinary Podocyte Excretion Predicts Urinary Protein Selectivity and Renal Prognosis

International Journal of Nephrology, 2022
Background. Urinary podocyte excretion is related to a reduction in glomerular podocyte numbers, glomerulosclerosis, and urinary protein selectivity.
Makoto Abe, Akiko Kaiga, Takehiro Ohira, Toshihiko Ishimitsu, Akihiro Tojo   +4 more
doaj   +1 more source

Podocyte Bioenergetics in the Development of Diabetic Nephropathy: The Role of Mitochondria

Endocrinology, 2021
Diabetic nephropathy (DN) is the leading cause of kidney failure, with an increasing incidence worldwide. Mitochondrial dysfunction is known to occur in DN and has been implicated in the underlying pathogenesis of disease.
Irena Audzeyenka, A. Bierzynska, A. Lay
semanticscholar   +1 more source

Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy

Military Medical Research, 2021
Background LncRNA AK044604 (regulator of insulin sensitivity and autophagy, Risa ) and autophagy-related factors Sirt1 and GSK3β play important roles in diabetic nephropathy (DN).
Peipei Su, Dongwei Liu, Sijie Zhou, Hang Chen, Xian-Ming Wu, Zhangsuo Liu   +5 more
semanticscholar   +1 more source

Podocyte Depletion in Thin GBM and Alport Syndrome.

PLoS ONE, 2016
The proximate genetic cause of both Thin GBM and Alport Syndrome (AS) is abnormal α3, 4 and 5 collagen IV chains resulting in abnormal glomerular basement membrane (GBM) structure/function. We previously reported that podocyte detachment rate measured in
Larysa Wickman, Jeffrey B Hodgin, Su Q Wang, Farsad Afshinnia, David Kershaw, Roger C Wiggins   +5 more
doaj   +1 more source

Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy

Journal of Diabetes Research, 2020
Diabetic nephropathy (DN) is not only an important microvascular complication of diabetes but also the main cause of end-stage renal disease. Studies have shown that the occurrence and development of DN are closely related to morphological and functional
Lili Zhang, Zhige Wen, Lin Han, Yujiao Zheng, Yu Wei, Xinmiao Wang, Qing Wang, Xinyi Fang, Linhua Zhao, Xiaolin Tong   +9 more
doaj   +1 more source

Tracking the stochastic fate of cells of the renin lineage after podocyte depletion using multicolor reporters and intravital imaging. [PDF]

PLoS ONE, 2017
Podocyte depletion plays a major role in focal segmental glomerular sclerosis (FSGS). Because cells of the renin lineage (CoRL) serve as adult podocyte and parietal epithelial cell (PEC) progenitor candidates, we generated Ren1cCre/R26R-ConfettiTG/WT and
Natalya V Kaverina, Hiroyuki Kadoya, Diana G Eng, Michael E Rusiniak, Maria Luisa S Sequeira-Lopez, R Ariel Gomez, Jeffrey W Pippin, Kenneth W Gross, Janos Peti-Peterdi, Stuart J Shankland   +9 more
doaj   +1 more source