Results 41 to 50 of about 41,440 (279)

Redox signaling, Nox5 and vascular remodeling in hypertension [PDF]

, 2015
Purpose of review: Extensive data indicate a role for reactive oxygen species (ROS) and redox signaling in vascular damage in hypertension. However, molecular mechanisms underlying these processes remain unclear, but oxidative post-translational ...
De Lucca Camargo, Livia, Dulak-Lis, Maria, Harvey, Adam, Montezano, Augusto C., Touyz, Rhian M., Tsiropoulou, Sofia   +5 more
core   +1 more source

Loss of Nup155 promotes high fructose-driven podocyte senescence by inhibiting INO80 mRNA nuclear export

Journal of Advanced Research
Introduction: Podocyte senescence causes podocyte loss and glomerulopathy. Excessive fructose intake is a risk factor for podocyte injury. However, whether high fructose promotes podocyte senescence remains unknown.
Li Chen, Tangdi Xu, Zixuan Wang, Chengzhi Wang, Lei Fang, Lingdong Kong   +5 more
doaj   +1 more source

The emerging role of cellular senescence in renal diseases [PDF]

, 2020
Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco, Chen, Rong, Francis, Heather, Glaser, Shannon, Li, Siwen, Li, Xuesen, Meng, Fanyin, Wan, Ying, Wu, Nan, Zhang, Chunmei, Zhou, Bingru, Zhou, Tianhao, Zou, Ping   +12 more
core   +1 more source

Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury.

PLoS ONE, 2014
Podocyte injury is the first step in the progression of glomerulosclerosis. Previous studies have demonstrated the beneficial effect of bone morphogenetic protein 7 (Bmp7) in podocyte injury and the existence of native Bmp signaling in podocytes.
Sachiko Yamada, Jin Nakamura, Misako Asada, Masayuki Takase, Taiji Matsusaka, Taku Iguchi, Ryo Yamada, Mari Tanaka, Atsuko Y Higashi, Tomohiko Okuda, Nariaki Asada, Atsushi Fukatsu, Hiroshi Kawachi, Daniel Graf, Eri Muso, Toru Kita, Takeshi Kimura, Ira Pastan, Aris N Economides, Motoko Yanagita   +19 more
doaj   +1 more source

The Updates of Podocyte Lipid Metabolism in Proteinuric Kidney Disease

Kidney Diseases, 2021
Background: Podocytes, functionally specialized and terminally differentiated glomerular visceral epithelial cells, are critical for maintaining the structure and function of the glomerular filtration barrier.
Yu Sun, Sijia Cui, Yunfeng Hou, Fan Yi
doaj   +1 more source

Activation of podocyte Notch mediates early Wt1 glomerulopathy [PDF]

, 2018
The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of ...
Alex K. Virasami, Aoife M. Waters, Barbaux, Barua, Bharathavikru, Boyer, Bruckner, Bruening, Cassady, Chau, Chen, Cheng, Cheng, Chernin, Chung, Dale Moulding, Denamur, Denys, Eve V. Miller-Hodges, Hartwig, Hastie, Hayashi, Jack Bellerby, Johns, Kakuda, Kann, Klamt, Krebs, Lefebvre, Lipska, Liu, Livak, Mona M. Tahoun, Morimoto, Murea, Neil J. Sebire, Niranjan, O'Brien, Okajima, Patek, Pelletier, Pelletier, Peter Hohenstein, Peter J. Scambler, Piscione, Rheault, Robert D. Sampson, Rowan I. Asfahani, Saran, Schiffer, Shigehara, Sweetwyne, Taelman, Toska, Totaro, Waters, Waters, White, Yang   +58 more
core   +1 more source

Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment. [PDF]

PLoS ONE, 2014
Glomerular diseases are commonly characterized by podocyte injury including apoptosis, actin cytoskeleton rearrangement and detachment. However, the strategies for preventing podocyte damage remain insufficient.
Yu-Lin Kang, Moin Ahson Saleem, Kwok Wah Chan, Benjamin Yat-Ming Yung, Helen Ka-Wai Law   +4 more
doaj   +1 more source

A rare case of renal thrombotic microangiopathy associated with Castleman’s disease [PDF]

, 2017
BACKGROUND: Castleman’s disease (CD) is an uncommon, heterogeneous lympho-proliferative disorder leading to high circulating levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF).
Chen, Ying Maggie, Cossey, L. Nicholas, Liapis, Helen, Mutneja, Ahubha   +3 more
core   +2 more sources

The Evolving Importance of Insulin Signaling in Podocyte Health and Disease

Frontiers in Endocrinology, 2018
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide, occuring in approximately one-third of diabetic patients.
Abigail C. Lay, Richard J. M. Coward
doaj   +1 more source

Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex [PDF]

, 2017
Albumin re-uptake is a receptor-mediated pathway located in renal proximal tubuli. There is increasing evidence of glomerular protein handling by podocytes, but little is known about the mechanism behind this process.
ANGLANI, FRANCA, CEOL, MONICA, DEL PRETE, DORELLA, GIANESELLO, LISA, PRIANTE, GIOVANNA, RADU, CLAUDIA-MARIA, Saleem, Moin A., SIMIONI, PAOLO, TERRIN, LILIANA   +8 more
core   +1 more source