Results 51 to 60 of about 48,174 (296)
Journal of Clinical Investigation, 2011 The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental ...
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Frontiers in Pharmacology, 2022 Podocytes form a key component of the glomerular filtration barrier. Damage to podocytes is referred to as “podocyte disease.” There are many causes of podocyte injury, including primary injury, secondary injury, and gene mutations.
Lirong Lin +5 more
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Kidney360, 2023 As the population in many industrial countries is aging, the risk, incidence, and prevalence of CKD increases. In the kidney, advancing age results in a progressive decrease in nephron number and an increase in glomerulosclerosis. In this review, we focus on the effect of aging on glomerular podocytes, the post-mitotic epithelial cells critical for the
Stuart J. Shankland +4 more
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Receptor-mediated endocytosis of α-galactosidase A in human podocytes in Fabry disease. [PDF]
PLoS ONE, 2011 Injury to the glomerular podocyte is a key mechanism in human glomerular disease and podocyte repair is an important therapeutic target. In Fabry disease, podocyte injury is caused by the intracellular accumulation of globotriaosylceramide.
Thaneas Prabakaran +8 more
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Podocyte-Released Migrasomes in Urine Serve as an Indicator for Early Podocyte Injury
Kidney Diseases, 2020 Background: Levels of urinary microvesicles, which are increased during various kidney injuries, have diagnostic potential for renal diseases. However, the significance of urinary microvesicles as a renal disease indicator is dampened by the difficulty ...
Y. Liu +8 more
semanticscholar +1 more source
Producing Purer Podocytes [PDF]
Journal of the American Society of Nephrology, 2019 Podocytes are highly specialized cells that play a central role in many renal disorders. For many years, podocyte research has been stymied by an inability to culture these cells in a well differentiated state.
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Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression.
Journal of Clinical Investigation, 2020 Utilizing the Nephrotic Syndrome Study Network Consortium and other publicly available transcriptomic datasets, we identified Retinoic acid receptor responder protein 1 (RARRES1) as a gene whose expression positively correlated with renal function ...
Anqun Chen +15 more
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Journal of Advanced ResearchIntroduction: Podocyte senescence causes podocyte loss and glomerulopathy. Excessive fructose intake is a risk factor for podocyte injury. However, whether high fructose promotes podocyte senescence remains unknown.
Li Chen +5 more
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Journal of the Endocrine Society, 2020 Diabetic kidney disease (DKD) is an important public health problem. Podocyte injury is a central event in the mechanism of DKD development. Podocytes are terminally differentiated, highly specialized glomerular visceral epithelial cells critical for the
Igor Kravets, S. Mallipattu
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Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury.
PLoS ONE, 2014 Podocyte injury is the first step in the progression of glomerulosclerosis. Previous studies have demonstrated the beneficial effect of bone morphogenetic protein 7 (Bmp7) in podocyte injury and the existence of native Bmp signaling in podocytes.
Sachiko Yamada +19 more
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