Results 51 to 60 of about 47,146 (309)
Enzymatic disease of the podocyte [PDF]
Pediatric Nephrology, 2010 Proteinuria is an early sign of kidney disease and has gained increasing attention over the past decade because of its close association with cardio-vascular and renal morbidity and mortality. Podocytes have emerged as the cell type that is critical in maintaining proper functioning of the kidney filter.
Andreas D. Kistler +5 more
openaire +3 more sources
Permselectivity of the glomerular wall examined with iron compound tracer [PDF]
, 1977 Rat kidney endothelial cell morphology was examined after introducing iron colloid particles of positive or negative charge to investigate the relationship between the electric charge and permeation through the glomerular capillary.
Hirata, Kooiti
core +1 more source
Journal of Advanced ResearchIntroduction: Podocyte senescence causes podocyte loss and glomerulopathy. Excessive fructose intake is a risk factor for podocyte injury. However, whether high fructose promotes podocyte senescence remains unknown.
Li Chen +5 more
doaj +1 more source
Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury.
PLoS ONE, 2014 Podocyte injury is the first step in the progression of glomerulosclerosis. Previous studies have demonstrated the beneficial effect of bone morphogenetic protein 7 (Bmp7) in podocyte injury and the existence of native Bmp signaling in podocytes.
Sachiko Yamada +19 more
doaj +1 more source
Role of miRNA-671-5p in Mediating Wnt/β-Catenin-Triggered Podocyte Injury
Frontiers in Pharmacology, 2022 Podocyte injury and proteinuria are the most common features of glomerular disease, which is the leading cause of end-stage renal failure. Hyperactivated Wnt/β-catenin signaling is closely associated with podocyte injury, but the underlying mechanisms ...
Chunhong Wang +8 more
doaj +1 more source
Trehalose, an mTOR independent autophagy inducer, alleviates human podocyte injury after puromycin aminonucleoside treatment. [PDF]
PLoS ONE, 2014 Glomerular diseases are commonly characterized by podocyte injury including apoptosis, actin cytoskeleton rearrangement and detachment. However, the strategies for preventing podocyte damage remain insufficient.
Yu-Lin Kang +4 more
doaj +1 more source
Inhibition of AMPKα Pathway by Podocyte GOLM1 Exacerbates Diabetic Nephrology in Mice. [PDF]
Adv Sci (Weinh)Podocyte Golgi membrane protein 1 interacts with epidermal growth factor receptor to inhibit peroxisome proliferator activated receptor γ, and then inactivates adenosine monophosphate activated protein kinase α pathway, which facilitates diabetes‐related inflammation, oxidative damage, apoptosis, and renal dysfunction.
Xu P +14 more
europepmc +2 more sources
American Journal of Physiology-Renal Physiology, 2017 according to the Centers for Disease Control and Prevention (CDC), >10% of US adults have chronic kidney disease (CKD), and one in two adults in the 30–64 age group is expected to develop CKD.
Vineet Gupta, Jochen Reiser
openaire +4 more sources
The function of endocytosis in podocytes [PDF]
Current Opinion in Nephrology & Hypertension, 2013 In this review, we discuss the role of endocytosis, a fundamental process internalizing molecules from the plasma membrane, and its critical importance in podocyte biology.Endocytic clathrin and nonclathrin-coated pits have been visualized in podocytes using electron microscopy, but the functional biological relevance has not been well defined.
Shuta Ishibe, Keita Soda
openaire +3 more sources
Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury
Frontiers in Pharmacology, 2022 Podocyte is also called glomerular epithelial cell, which has been considered as the final gatekeeper of glomerular filtration barrier (GFB). As a major contributor to proteinuria, podocyte injury underlies a variety of glomerular diseases and becomes ...
Tianwen Yao +6 more
doaj +1 more source