Results 71 to 80 of about 48,174 (296)

Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injury. [PDF]

PLoS ONE, 2012
BACKGROUND: Glomerulosclerosis correlates with reduction in podocyte number that occurs through mechanisms which include apoptosis. Podocyte injury or podocyte loss in the renal glomerulus has been proposed as the crucial mechanism in the development of ...
Shuangxin Liu, Wei Shi, Houqin Xiao, Xinling Liang, Chunyu Deng, Zhiming Ye, Ping Mei, Suxia Wang, Xiaoying Liu, Zhixin Shan, Yongzheng Liang, Bin Zhang, Wenjian Wang, Yanhui Liu, Lixia Xu, Yunfeng Xia, Jianchao Ma, Zhilian Li   +17 more
doaj   +1 more source

Role of miRNA-671-5p in Mediating Wnt/β-Catenin-Triggered Podocyte Injury

Frontiers in Pharmacology, 2022
Podocyte injury and proteinuria are the most common features of glomerular disease, which is the leading cause of end-stage renal failure. Hyperactivated Wnt/β-catenin signaling is closely associated with podocyte injury, but the underlying mechanisms ...
Chunhong Wang, Jiafeng Liu, Xiaoyao Zhang, Qiyan Chen, Xiaoyan Bai, Xue Hong, Lili Zhou, Youhua Liu, Youhua Liu   +8 more
doaj   +1 more source

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression. [PDF]

PLoS ONE, 2015
Glomerular podocytes are highly differentiated cells that are key components of the kidney filtration units. The podocyte cytoskeleton builds the basis for the dynamic podocyte cytoarchitecture and plays a central role for proper podocyte function ...
Stefanie Jeruschke, Kay Jeruschke, Andrew DiStasio, Sinem Karaterzi, Anja K Büscher, Perihan Nalbant, Ludger Klein-Hitpass, Peter F Hoyer, Jürgen Weiss, Rolf W Stottmann, Stefanie Weber   +10 more
doaj   +1 more source

Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury

Frontiers in Pharmacology, 2022
Podocyte is also called glomerular epithelial cell, which has been considered as the final gatekeeper of glomerular filtration barrier (GFB). As a major contributor to proteinuria, podocyte injury underlies a variety of glomerular diseases and becomes ...
Tianwen Yao, Wenxiang Su, Shisheng Han, Yan Lu, Yanqiu Xu, Min Chen, Yi Wang   +6 more
doaj   +1 more source

Nestin protects podocyte from injury in lupus nephritis by mitophagy and oxidative stress

Cell Death and Disease, 2020
Podocyte injury is the main cause of proteinuria in lupus nephritis (LN). Nestin, an important cytoskeleton protein, is expressed stably in podocytes and is associated with podocyte injury.
Yuexin Tian, Huifang Guo, Xinyan Miao, Jie Xu, Ran Yang, Lu Zhao, Jin-xi Liu, Lin Yang, Fan Gao, Wei Zhang, Qingjuan Liu, Shaoguang Sun, Yuexin Tian, Hongbo Li, Jie Huang, Cunyang Gu, Shuxia Liu, Xiaojuan Feng   +17 more
semanticscholar   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Effect of N-acetyl-seryl-aspartyl-lysyl-proline on high glucose-induced podocyte injury

Linchuang shenzangbing zazhi, 2018
Objective To investigate the effect of N-acetyl-seryl-aspartyl-lysyl-proline(AcSDKP) on podocyte injury induced by high glucose and its possible mechanisms.Methods The conditionally immortalized mouse podocytes were treated by high glucose with or ...
ZHA Dong-qing, GAO Ping, WU Xiao-yan
doaj  

Tangeretin Ameliorates Glucose-Induced Podocyte Injury through Blocking Epithelial to Mesenchymal Transition Caused by Oxidative Stress and Hypoxia

International Journal of Molecular Sciences, 2020
Podocyte injury inevitably results in leakage of proteins from the glomerular filter and is vital in the pathogenesis of diabetic nephropathy (DN).
Min-Kyung Kang, Soo-il Kim, S. Oh, Woojin Na, Young‐Hee Kang   +4 more
semanticscholar   +1 more source