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Aldosterone and glomerular podocyte injury

Clinical and Experimental Nephrology, 2008
Aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis by acting on the distal nephron. Accumulating evidence suggests that aldosterone also plays pathogenetic roles in cardiovascular and renal injury. For example, aldosterone is a potent inducer of proteinuria.
Miki, Nagase, Toshiro, Fujita
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Urinary Biomarkers of Podocyte Injury

Biomarkers in Medicine, 2008
Podocyturia may be an expression of glomerular disease and is evaluated using urinary podocyte-specific molecules. This article discusses the technical problems of detection and quantification of podocyturia using immunofluorescent staining of specific proteins, urinary podocyte culture, flow cytometry and urinary podocyte-specific molecules (including
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Immunohistochemical and urinary markers of podocyte injury

Pediatric Nephrology, 1998
Renal podocytes play an important role in glomerular filtration. We estimated podocyte injury by light microscopic examination of kidney specimens or by urinary excretion of substances related to podocytes. Fresh kidney sections from 69 patients and urinary sediments from 84 patients with various renal diseases were examined immunohistochemically using
M, Hara   +4 more
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Podocyte injury and targeting therapy: an update

Current Opinion in Nephrology & Hypertension, 2006
Podocyte injury is a central event in the development of glomerulosclerosis. This review highlights contributions from the past year to our understanding of mechanisms of podocyte injury and implications for potential treatment strategies of glomerular disease.Rearrangement of the actin cytoskeleton, the backbone linking the slit diaphragm, apical ...
Raghu V, Durvasula, Stuart J, Shankland
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