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Podocyte Injury and Glomerulosclerosis in Hyperhomocysteinemic Rats
American Journal of Nephrology, 2007<i>Background/Aims:</i> We previously reported that increase in plasma homocysteine (Hcys) levels by a 6-week methionine treatment produced remarkable glomerular injury. However, the mechanism by which hyperhomocysteinemia (hHcys) produces glomerular injury remains unknown.
Fan, Yi +5 more
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2014
Background: The podocyte is central to the glomerular filtration barrier and is particularly important in the disease process of focal segmental glomerulosclerosis (FSGS). The podocyte is injured in two main ways in idiopathic nephrotic syndrome. The first is by single gene disorders, such as NPHS1, NPHS2, CD2AP and TRPC6, which has led to a focus on ...
Wen Yi Ding, Moin A. Saleem
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Background: The podocyte is central to the glomerular filtration barrier and is particularly important in the disease process of focal segmental glomerulosclerosis (FSGS). The podocyte is injured in two main ways in idiopathic nephrotic syndrome. The first is by single gene disorders, such as NPHS1, NPHS2, CD2AP and TRPC6, which has led to a focus on ...
Wen Yi Ding, Moin A. Saleem
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BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury
American Journal of Physiology-Renal Physiology, 2007In early diabetic renal injury, there is podocyte drop-out (but no decrease in the number of other glomerular cells) which is thought to cause glomerular proteinuria and subsequent diabetic glomerular injury. We tested the hypothesis that early diabetic podocyte injury is caused, in part, by downregulation of bone morphogenetic protein-7 (BMP7) and ...
Grace M, Mitu +2 more
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Role of Podocyte Injury in IgA Nephropathy
2013IgA nephropathy (IgAN) encompasses different pathological entities, all of which are characterized by the mesangial deposition of IgA. Aberrantly glycosylated IgA molecules appear to play a major role in the pathogenesis of IgAN. Both genetic and environmental factors contribute to the formation of IgG antibodies that binds to aberrantly glycosylated ...
Madhav C, Menon +2 more
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Role of Mitochondria in Podocyte Injury
2014Mitochondria are cellular organelles that produce the energy required for cellular processes through synthesis of adenosine triphosphate (ATP). They also contribute to a wide range of cellular functions, including reactive oxygen species (ROS) generation, calcium homeostasis, and induction of apoptosis. Mitochondria also contain their own DNA, known as
Yanggang Yuan +2 more
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Cell Cycle and Podocyte Injury
2014Background: The cell cycle is regulated by cyclins activating cyclin-dependent kinases (Cdk). Cdk inhibitors bind to and inhibit cyclin-Cdk complexes.
Henning Hagmann +2 more
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Sirtuins as novel pharmacological targets in podocyte injury and related glomerular diseases
Biomedicine and Pharmacotherapy, 2022Yongli Zhan, Huimin Mao
exaly
Rapamycin attenuated podocyte apoptosis via upregulation of nestin in Ang II-induced podocyte injury
Molecular Biology Reports, 2022Aiqing Zhang, Yajie Zhao
exaly
Podocyte injury in extreme obesity
International Journal of ObesityNobuo Tsuboi +2 more
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Dexamethasone resisted podocyte injury
2014CD2AP and TRPC6, the key proteins of podocyte slit diaphragm (SD), together form a signal transduction complex by interacting with other SD molecules and also play an important role in maintaining SD structural and functional integrity. Data suggest that podocyte injury or SD structural damage will inevitably result in proteinuria.
You, YS, Li, Y, Yao, Z
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