Results 91 to 100 of about 34,405 (271)

Podocyte injury damages podocytes in chimeric organoids

Abstract We have previously shown that injury to a subset of podocytes can trigger secondary damage in neighboring podocytes, but whether this phenomenon depends on direct intercellular interaction is unknown. To address this, kidney organoids were generated from nephron progenitor cells of two mouse lines: one expressing a receptor for a ...
Tomohiro Udagawa, Toshikazu Araoka, Kenji Osafune, Taiji Matsusaka   +3 more
openaire   +1 more source

Fabry Disease Podocytes Reveal Ferroptosis as a Potential Regulator of Cell Pathology

Kidney International Reports
Introduction: Fabry disease (FD) results from pathogenic GLA variants, leading to a deficiency in lysosomal α-galactosidase A (α-Gal A) and accumulation of the sphingolipid globotriaosylceramide (Gb3).
Andrea F. Wise, IGAA Ari Krisnadevi, Shoni Bruell, Han-Chung Lee, Tejasvini Bhuvan, Andrew J. Kassianos, Sheetal Saini, Xiangju Wang, Helen G. Healy, Elizabeth Ling Qian, David A. Elliot, Joel R Steele, Maria Fuller, Kathleen M. Nicholls, Sharon D. Ricardo   +14 more
doaj   +1 more source

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF‐κB pathway

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Inflammation plays an essential role in the pathogenesis of diabetic nephropathy (DN). Linderalactone (LNL), as a natural sesquiterpene lactone, has been discovered to have anti‐inflammatory activation. However, the effects of linderalactone on diabetes‐associated renal damage remain unclear.
Hao Chen, Sheng Xu, Bingrong Chen, Xishan Xiong, Jinrui Hu, Yuhong Wu, Tianrui Wang, Huishang Wang   +7 more
wiley   +1 more source

Assessment of podocyte detachment as a pivotal step in the development of focal segmental glomerulosclerosis

Journal of the Egyptian National Cancer Institute
Background Podocytopenia refers to a decrease in the number of podocytes. When podocytes are injured, they may detach leading to podocytopenia, which represents a critical step in the development of podocytopathy and subsequently deterioration of renal ...
Ikbal Ahmed Abdo Elkholy, Wagdi Elkashef, Fatma El-Husseini Mostafa, Amany Hassan   +3 more
doaj   +1 more source

The biology of PKM2 in the metabolism and senescence in diabetic kidney disease

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Diabetic kidney disease (DKD) is one of the most common causes of chronic kidney disease that leads to end‐stage kidney disease, and its progression is closely linked to metabolic stress within renal tubular cells. Under long‐term hyperglycemia, cells shift their glucose metabolism from normal oxidative phosphorylation toward glycolysis.
Md. Imrul Kayes, Keizo Kanasaki
wiley   +1 more source

Knowledge Domain and Emerging Trends in Podocyte Injury Research From 1994 to 2021: A Bibliometric and Visualized Analysis

, 2021
Tong‐Tong Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Yongli Zhan   +5 more
openalex   +1 more source

Remnant cholesterol/high‐density lipoprotein cholesterol ratio is a new powerful tool for identifying diabetic kidney disease

Journal of Diabetes Investigation, EarlyView.
Remnant cholesterol to high‐density lipoprotein cholesterol ratio exhibits a positive association with the risk of diabetic kidney disease. ABSTRACT Background Remnant cholesterol to high‐density lipoprotein cholesterol ratio (RHR) has been identified as a reliable predictor for metabolic disease risk.
Jiale Zhang, Shuping Zhou, Haojie Zhang, Jiang Liu   +3 more
wiley   +1 more source

Isolation of Podocyte Cell Fractions From Mouse Kidney Using Magnetic Activated Cell Sorting (MACS)

Bio-Protocol
Glomerular diseases characterized by injury to post-mitotic epithelial cells called podocytes are a leading cause of chronic kidney disease. Yet, isolating podocytes from the kidney for transcriptomic, proteomic, and metabolomic studies has been a major ...
Jeffrey Pippin, Carol Loretz, Diana Eng, Oliver Wessely, Stuart Shankland   +4 more
doaj   +1 more source

Overexpression of Mafb in Podocytes Protects against Diabetic Nephropathy [PDF]

, 2014
Naoki Morito, Keigyou Yoh, Masami Ojima, Midori Okamura, Megumi Nakamura, Michito Hamada, Homare Shimohata, Takashi Moriguchi, Kunihiro Yamagata, Satoru Takahashi   +9 more
openalex   +1 more source

CD36 and Its Role in Obesity

Obesity Reviews, EarlyView.
ABSTRACT Obesity is understood as a condition driven by interactions between genetics and environmental factors. The role of CD36 in the regulation of lipid metabolism and ectopic fat accumulation emerges as a key area of interest. This review presents CD36 not only as a crucial facilitator of fatty acid uptake but also as a regulator of how and where ...
Nahuel Garcia, Maiken Mellergaard, Carlos Salomon, Pilar Sepulveda, Peter Kristensen, Aase Handberg   +5 more
wiley   +1 more source