P4‐ATPases as Phospholipid Flippases: From Membrane Dynamics to Human Disorders
Medicine Bulletin, EarlyView.ABSTRACT P4‐ATPases (P4 subfamily of P‐type ATPases) flippase complex includes an α‐subunit responsible for catalysis and a supporting β‐subunit, which consumes energy by catalyzing the hydrolysis of ATP, thereby facilitating the translocation of aminophospholipids from the outer to the inner leaflet of cellular membranes to maintain the asymmetric ...
Guangyi Chen, Yeming Yang, Xianjun Zhu
wiley +1 more source
Dach1 is essential for maintaining normal mature podocytes.
PLoS ONEDach1 is highly expressed in normal podocytes, but this expression rapidly disappears after podocyte injury. To investigate the role of Dach1 in podocytes in vivo, we analyzed global, podocyte-specific, and inducible Dach1 knockout mice.
Keiko Tanaka +2 more
doaj +1 more source
Journal of Diabetes Research, 2020 Tangshen Formula (TSF) is a Chinese Medicine formula that has been reported to alleviate proteinuria and protect renal function in humans and animals with diabetic kidney disease (DKD).
Qian Wang +9 more
doaj +1 more source
Gα12 Activation in Podocytes Leads to Cumulative Changes in Glomerular Collagen Expression, Proteinuria and Glomerulosclerosis [PDF]
, 2012 Glomerulosclerosis is a common pathologic finding that often progresses to renal failure. The mechanisms of chronic kidney disease progression are not well-defined but may include activation of numerous vasoactive and inflammatory pathways.
Beaudry, Sarah +7 more
core +1 more source
Scientific Reports, 2017 Podocyte apoptosis coincides with albuminuria onset and precedes podocytopenia in diabetic nephropathy. However, there is a lack of effective therapeutic drugs to protect podocytes from apoptosis.
Shanqing Huang +12 more
semanticscholar +1 more source
Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives
PROTEOMICS, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto +2 more
wiley +1 more source
Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure [PDF]
, 2016 Pharmacological blockade of the N-and L-type calcium channel lessens renal injury in kidney disease patients. The significance of specific blockade of α1 subunit of N-type calcium channel, Cav2.2, in diabetic nephropathy, however, remains to be clarified.
Fujikura, Junji +15 more
core +3 more sources
Growth hormone induces TNF-α in podocytes and contributes to monocyte-to-macrophage differentiation: Implications in Diabetic kidney disease [PDF]
, 2022 Anil Kumar Pasupulati +6 more
openalex +1 more source
Nrf2‐Mediated Ferroptosis Is Involved in Berberine‐Induced Alleviation of Diabetic Kidney Disease
Phytotherapy Research, EarlyView.ABSTRACT Diabetic kidney disease (DKD) is the most common and serious complication of diabetes mellitus. Currently, there is a lack of safe and effective preventive strategies for DKD. The study aimed to explore the preventive effects and potential mechanisms of berberine (BBR) against DKD.
Kun Gao +6 more
wiley +1 more source
Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells
Frontiers in Immunology, 2018 Calcium calmodulin kinase IV (CaMK4) regulates multiple processes that significantly contribute to the lupus-related pathology by controlling the production of IL-2 and IL-17 by T cells, the proliferation of mesangial cells, and the function and ...
Andrew P. Ferretti +4 more
doaj +1 more source