Results 71 to 80 of about 27,144 (229)

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Investigate the Effects of Preeclampsia Severity, Race and Fetal Sex on Subsequent Maternal Complications Using EHR Data From Over 100,000 Pregnancies

iMetaMed, EarlyView.
We examined Preeclampsia‐associated comorbidities in the UM Discovery Cohort using confounder‐adjusted models, validated across UK Biobank, Cedars‐Sinai, and Vanderbilt, revealing condition‐specific risks supported by OR estimates and KM survival curves.
Xiaotong Yang, Haoming Zhu, Leyang Tao, Raelynn Chen, Jui‐Hsuan Chang, Zhiping P. Wang, Elizabeth S. Langen, Ashley M. Hesson, Cosmin A. Bejan, Ruowang Li, Lana X. Gamire   +10 more
wiley   +1 more source

Dach1 is essential for maintaining normal mature podocytes.

PLoS ONE
Dach1 is highly expressed in normal podocytes, but this expression rapidly disappears after podocyte injury. To investigate the role of Dach1 in podocytes in vivo, we analyzed global, podocyte-specific, and inducible Dach1 knockout mice.
Keiko Tanaka, Haruko Hayasaka, Taiji Matsusaka   +2 more
doaj   +1 more source

Podocytes [PDF]

The American Journal of Pathology, 2020
Marica Giliberti, Adele Mitrotti, Loreto Gesualdo   +2 more
openaire   +1 more source

Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway

iMetaMed, EarlyView.
IL‐6 from RTECs upregulates TGF‐β in macrophages, promoting fibroblast transdifferentiation. Isorhamnetin inhibits this effect. ABSTRACT Chronic kidney disease (CKD) is a major global health issue. Kidney fibrosis is a key mechanism leading to end‐stage renal disease.
Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun   +8 more
wiley   +1 more source

Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells

Frontiers in Immunology, 2018
Calcium calmodulin kinase IV (CaMK4) regulates multiple processes that significantly contribute to the lupus-related pathology by controlling the production of IL-2 and IL-17 by T cells, the proliferation of mesangial cells, and the function and ...
Andrew P. Ferretti, Rhea Bhargava, Shani Dahan, Maria G. Tsokos, George C. Tsokos   +4 more
doaj   +1 more source

Glomerular endothelial derived vesicles mediate podocyte dysfunction: A potential role for miRNA.

PLoS ONE, 2020
MicroRNAs (miRNA) are shown to be involved in the progression of several types of kidney diseases. Podocytes maintain the integrity of the glomerular basement membrane.
N Hill, D L Michell, M Ramirez-Solano, Q Sheng, C Pusey, K C Vickers, K J Woollard   +6 more
doaj   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

The integrin repertoire drives YAP-dependent epithelial:stromal interactions during injury of the kidney glomerulus

Nature Communications
The kidney glomerulus is a filtration barrier in which capillary loop architecture depends on epithelial-stromal interactions between podocytes and mesangial cells.
Evelyne Huynh-Cong, Victoria Driscoll, Sandrine Ettou, Keith Keller, Amha Atakilit, Mary E. Taglienti, Saurabh Kumar, Astrid Weins, Valerie A. Schumacher, Jordan A. Kreidberg   +9 more
doaj   +1 more source