Results 71 to 80 of about 68,048 (352)

Role of the podocyte in proteinuria [PDF]

Pediatric Nephrology, 2011
In recent years, the podocyte, with its elaborate cytoarchitecture and slit diaphragm, has been the focus of extensive research, yet its precise role in the glomerular filtration barrier is still debated. There are puzzling observations indicating that a comprehensive mechanistic model for glomerular filtration is still necessary.
Menzel, Sylvia, Moeller, Marcus J.
openaire   +2 more sources

Podocytes and autophagy: a potential therapeutic target in lupus nephritis

Autophagy, 2019
Recent studies suggest that defects in macroautophagy/autophagy contribute to the pathogenesis of systemic lupus erythamatosus (SLE), especially in adaptive immunity.
Xu-jie Zhou, D. Klionsky, Hong Zhang
semanticscholar   +1 more source

Kynurenine Pathway Dysregulation Impairs Podocyte Morphology and Bioenergetics In Vitro and Leads to Glomerular Dysfunction. [PDF]

FASEB J
The enzymes of the kynurenine pathway participate in the catabolism of TRP, where they generate metabolites known as kynurenines, which are considered biologically active. Using a transgenic zebrafish line, we showed that systemic changes in the kynurenine pathway lead to edema and proteinuria, both signs of an impaired glomerular filtration barrier ...
Bolanos-Palmieri P, Schenk H, Bähre H, Schroder P, Staggs L, Haller H, Schiffer M.   +6 more
europepmc   +2 more sources

A membranous nephropathy variant mimicking minimal change disease. [PDF]

J Pathol Clin Res
Abstract This study characterizes a novel disease pattern of membranous nephropathy (MN) that exhibits overlapping clinicopathological features with minimal change disease (MCD), termed ‘MCD‐like MN’. Patients with histologically confirmed MN showing sparse and segmental subepithelial electron‐dense deposits (EDD) but clinically resembling MCD were ...
Pan C, Xiang S, Jiang M, Li Y, Huang B, Ye T, Du Y, Tang X, Yuan Y.   +8 more
europepmc   +2 more sources

Erk5 is a mediator to TGFβ1-induced loss of phenotype and function in human podocytes. [PDF]

, 2014
Background: Podocytes are highly specialized cells integral to the normal functioning kidney, however, in diabetic nephropathy injury occurs leading to a compromised phenotype and podocyte dysfunction which critically produces podocyte loss with ...
Binder, Browne, Chuang, Dalla Vestra, Dessapt, Dorado, Drew, Fioretto, Gagliardini, Goldfarb, Hayashi, Herbach, Herman-Edelstein, Huang, Iwano, Khalil, Kim, Kim, Li, Maeda, Marchetti, Niculescu-Duvaz, Pavenstädt, Phanish, Reeves, Regan, Rocco, Saleem, Schiffer, Shishido, Siegel, Suzaki, Vardouli, Wahab, Winn, Woo, Wu, Zhou, Ziyadeh, Ziyadeh   +39 more
core   +2 more sources

Enzymatic disease of the podocyte [PDF]

Pediatric Nephrology, 2010
Proteinuria is an early sign of kidney disease and has gained increasing attention over the past decade because of its close association with cardio-vascular and renal morbidity and mortality. Podocytes have emerged as the cell type that is critical in maintaining proper functioning of the kidney filter.
Andreas D, Kistler, Vasil, Peev, Anna-Lena, Forst, Shafic, El Hindi, Mehmet M, Altintas, Jochen, Reiser   +5 more
openaire   +2 more sources

Hydroxychloroquine Associated With Lower Glomerular Filtration Rate Decline in Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long‐term benefits of HCQ on kidney function preservation is critical.
Shivani Garg, Brad Rovin, Brad C. Astor, Tripti Singh, Fauzia Hollnagel, Megan Kuik, Lexie Kolton, Callie Saric, S. Sam Lim, Christie M. Bartels   +9 more
wiley   +1 more source

A Liquid-Based Cytology System, without the Use of Cytocentrifugation, for Detection of Podocytes in Urine Samples of Patients with Diabetic Nephropathy

Journal of Diabetes Research, 2019
Objective. Podocytes have highly differentiated functions and are extremely difficult to grow; thus, damage of podocytes is associated with glomerular dysfunction.
Moritsugu Kimura, Masao Toyoda, Nobumichi Saito, Noriko Kaneyama, Han Miyatake, Eitaro Tanaka, Hirotaka Komaba, Masanori Hara, Masafumi Fukagawa   +8 more
doaj   +1 more source

ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases

Journal of Biomedical Science, 2010
Background The importance of the Notch signaling in the development of glomerular diseases has been recently described. Therefore we analyzed in podocytes the expression and activity of ADAM10, one important component of the Notch signaling complex ...
Weide Thomas, Hillmann Anja, Gauer Stefan, Altevogt Peter, Ludwig Andreas, Hauser Ingeborg A, Doberstein Kai, Abdel-Bakky Mohamed, Schramme Anja, Gutwein Paul, Jespersen Christine, Eberhardt Wolfgang, Pfeilschifter Josef   +12 more
doaj   +1 more source

Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1 [PDF]

, 2018
Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non ...
Carbo, Miriam, Failla, Cristina M., Morea, Veronica   +2 more
core   +2 more sources