Bioconjugation of Podophyllotoxin and Nanosystems: Approaches for Boosting Its Biopharmaceutical and Antitumoral Profile [PDF]
PharmaceuticalsPodophyllotoxin is a natural compound belonging to the lignan family and is well-known for its great antitumor activity. However, it shows several limitations, such as severe side effects and some pharmacokinetics problems, including low water solubility,
Carolina Miranda-Vera +5 more
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Characterizing the impact of podophyllotoxin on pulmonary toxicity and gut-lung microbiota interactions in SD rats based on TEC concept [PDF]
Microbiology SpectrumPodophyllotoxin (PPT), an extract from the traditional medicinal plant Dysosma, offers anti-viral and anti-cancer benefits, though its use is limited by toxicity. The mechanisms of PPT’s inherent pulmonary toxicity remain elusive.
Min Wang +6 more
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Frontiers in Chemistry, 2023 Three series of podophyllotoxin derivatives with various nitrogen-containing heterocycles were designed and synthesized. The antitumor activity of these podophyllotoxin derivatives was evaluated in vitro against a panel of human tumor cell lines.
Meng Yin +11 more
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Green Ultrasound-Assisted Extraction of Podophyllotoxin from Juniperus scopulorum Needles
Applied Sciences, 2023 Background—Podophyllotoxin, a polyphenolic compound with major applications in cancer treatment, is in short supply, as its source is now an endangered plant species.
Catherine Verret +2 more
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Pharmaceutics, 2023 Podophyllotoxin is a naturally occurring cyclolignan isolated from rhizomes of Podophyllum sp. In the clinic, it is used mainly as an antiviral; however, its antitumor activity is even more interesting. While podophyllotoxin possesses severe side effects
Carolina Miranda-Vera +5 more
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Synthesis, structure, thermal, magnetic, dielectric properties of Ce3+doped M-type SrFe12O19 and electrochemical determination of L-cysteine [PDF]
, 2022 Cerium substituted SrFe12O19 with the nano composition of Sr(1-x)CexFe12O19 (x = 0.00, 0.01, 0.05 and 0.09) have been prepared using auto-combustion technique with dual fuel.
Hanumantha Nayak, R. +5 more
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Essential Oil Composition and Bioactivity of Two Juniper Species from Bulgaria and Slovakia
Molecules, 2021 Juniperus excelsa M. Bieb and J. sabina L. contain essential oil (EO), while J. sabina also contains podophyllotoxin, which is used as a precursor for anti-cancer drugs. Two studies were conducted. The first assessed the variability in the EO profile and
Valtcho D. Zheljazkov +10 more
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Podophyllotoxin: History, Recent Advances and Future Prospects
Biomolecules, 2021 Podophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the frontline chemotherapeutic drug used against various cancers due to its superior
Zinnia Shah +9 more
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Synthesis and Anticancer Activity of 4β-Triazole-podophyllotoxin Glycosides [PDF]
, 2014 The objective of present study was to investigate the effect of various sounds on the green mustard’s (Brassica Juncea) morphology characteristic and productivity.
Cheng-Ting Zi +6 more
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Synthesis and evaluation of antimitotic activity of new tetralone acid analogues of podophyllotoxin [PDF]
, 2014 The new tetralone acids I (R = H, F, Me, OMe, SMe) were synthesized as analogs of podophyllotoxin. They were prepd. by replacing 3,4,5-trimethoxyphenyl ring with cyclohexyl group in podophyllotoxin and 1,3-methylene dioxy ring with methoxy, hydrogen, Me,
Basavaraju, Y. B. +4 more
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