Biologia Plantarum, 2016 Podophyllum hexandrum Royle is an important medicinal herb of North-Western Himalayas, and podophyllotoxin, being its major metabolite, has been used extensively in the preparation of several anticancer drugs.
P. Kumar +3 more
doaj +1 more source
Methyl Jasmonate Regulates Podophyllotoxin Accumulation in Podophyllum hexandrum by Altering the ROS-Responsive Podophyllotoxin Pathway Gene Expression Additionally through the Down Regulation of Few Interfering miRNAs [PDF]
, 2017 Podophylloxin (ptox), primarily obtained from Podophyllum hexandrum, is the precursor for semi-synthetic anticancer drugs viz. etoposide, etopophos, and teniposide.
Apel +46 more
core +1 more source
Junipers of Various Origins as Potential Sources of the Anticancer Drug Precursor Podophyllotoxin
Molecules, 2021 Juniper representatives are natural sources of plenty of bioactive metabolites and have been used since ancient times as folk remedies against tapeworms, warts, cancer, etc.
Diana I. Ivanova +9 more
doaj +1 more source
Die Biosynthese cytotoxischer Lignane aus Linum nodiflorum L. (Linaceae): ß-Peltatin 6-O-Methyltransferase [PDF]
, 2004 Lignane sind im Pflanzenreich weit verbreitete phenolische Sekundärstoffe, von denen Vertreter mit cytotoxischer, antimykotischer und antimikrobieller Wirkung bekannt sind.
Kranz, Kerstin +1 more
core +1 more source
Plants, 2023 Podophyllotoxin (PPT) is a precursor for the synthesis of drugs against cancer and other diseases. The present sources of PPT (Sinopodophyllum hexandrum and Podophyllum peltatum) are endangered species, with PPT production highly dependent on their ...
Diana Ivanova +8 more
doaj +1 more source
Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis [PDF]
, 2019 Background More than 10 years have elapsed since human papillomavirus (HPV) vaccination was implemented. We did a systematic review and meta-analysis of the population-level impact of vaccinating girls and women against human ...
\uc9lodie, B\ue9nard +50 more
core +2 more sources
Antiproliferation and cell apoptosis inducing bioactivities of constituents from Dysosma versipellis in PC3 and Bcap-37 cell lines [PDF]
, 2011 Background Recently, interest in phytochemicals from traditional Chinese medicinal herbs with the capability to inhibit cancer cells growth and proliferation has been growing rapidly due to their nontoxic nature.
Xiaoqiang Xu +7 more
core +2 more sources
The Effect of Podophyllotoxin as an Inducer of Apoptosis Using Molecular Docking Method
Armaghane Danesh Bimonthly Journal, 2021 Background and aim: Podophyllotoxin is used as one of the main treatments for genital warts. It is a precursor of etoposide and teniposide, which is used in the treatment of various cancers.
MS Talebianpoor +2 more
doaj
Journal of Medical Microbiology and Infectious Diseases, 2023 Introduction: Cholera is a highly contagious disease that causes severe diarrhea and dehydration. This study investigated podophyllotoxin, deoxypodophyllotoxin, and ursolic acid as inhibitors of tcpA, ompW, and ctxB genes in Vibrio cholerae.
Yasin SarveAhrabi1* +2 more
doaj +1 more source
Methyltrioxorhenium catalysed synthesis of highly oxidised aryltetralin lignans with anti-topoisomerase II and apoptogenic activities [PDF]
, 2005 A novel and efficient procedure to prepare highly oxidised aryltetralin lignans, such as isopodophyllotoxone and (-)-aristologone derivatives, by oxidation of podophyllotoxin and galbulin with methylrhenium trioxide (MTO) and novel MTO heterogeneous ...
Belfiore, Maria Cristina +5 more
core +1 more source