Results 41 to 50 of about 8,560 (165)

Drug Delivery Systems for Resiquimod to Control Myeloid‐Derived Suppressor Cells in Cancer Immunotherapy

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Myeloid‐derived suppressor cells (MDSCs) are key contributors to cancer immunotherapy failure and major targets in new therapeutic strategies. We highlight therapeutic approaches to counteract their immunosuppressive functions and discuss recent efforts to optimize drug delivery for controlling MDSCs, focusing on resiquimod as a representative drug ...
Yanying He, Yoon Yeo
wiley   +1 more source

Pharmakokinetik von Etoposidphosphat [PDF]

, 2004
In der vorliegenden Arbeit wird die Pharmakokinetik des Zytostatikums Etoposid nach intravenöser Gabe von Etoposid-Phosphat untersucht. Die quantitative Analyse wurde mit der 252-Californium-Plasma-Desorptions-Massenspektrometrie nach
Barth, Axel, Jungclas, Hartmut (Prof. Dr.)   +1 more
core   +1 more source

Expanding the Toolbox for Hydrogen Atom Transfer Catalysis: Sulfides as Structurally Diverse Catalysts Under Photoredox Conditions

Advanced Synthesis &Catalysis, Volume 368, Issue 4, 17 February 2026.
A new class of sulfide‐based catalysts for visible‐light‐driven hydrogen‐atom transfer (HAT) are reported. Single‐electron oxidation of alkyl aryl sulfides generates radical cations as the active HAT species whose catalytic activities are boosted by installing the 2‐thiazolyl structure.
Tetsuya Sengoku, Shun Nishioka, Yu Kokoda, Yoshifumi Noguchi, Toshiyasu Inuzuka   +4 more
wiley   +1 more source

Distinct requirements for the Rad32(Mre¹¹) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA [PDF]

, 2009
For a cancer cell to resist treatment with drugs that trap topoisomerases covalently on the DNA, the topoisomerase must be removed. In this study, we provide evidence that the Schizosaccharomyces pombe Rad32Mre11 nuclease activity is involved in the ...
Akamatsu, Antony M. Carr, Baldwin, Champoux, Connelly, Connelly, Edgar Hartsuiker, El-Khamisy, Farah, Gutz, Hartsuiker, Hopfner, Hopfner, Keeney, Keeney, Krogh, Krogh, Lengsfeld, Limbo, Liu, Malik, Matthew J. Neale, McKee, Miyoshi, Moreau, Neale, Nitiss, Osheroff, Porter, Pouliot, Prinz, Sartori, Shaw, Stracker, Subramanian, Takashima, Tomita, Utsugi, Young   +38 more
core   +2 more sources

P‐Chiral (Biaryl phosphine)gold(I) Complexes in Asymmetric Cyclizations of Diverse 1‐Aryl‐1,6‐enynes

ChemistryEurope, Volume 4, Issue 2, February 2026.
A new family of P‐chiral biaryl phosphine ligands coordinates gold and the resulting complexes catalyze asymmetric 1,6‐enyne cycloisomerization reactions affording cyclopentano dihydronaphthalenes in good yields with mostly high enantioselectivity. The approach is applicable to the synthesis of a podophyllotoxin analog.
Nguyen Huu Trong Phan, Radek Pohl, Miroslav Hájek, Ivana Císařová, Ullrich Jahn   +4 more
wiley   +1 more source

Isolation and Cytotoxic Potency of Endophytic Fungi Associated with Dysosma difformis, a Study for the Novel Resources of Podophyllotoxin

Mycobiology, 2022
Endophytic fungi are promising sources for the production of podophyllotoxin-an important anticancer compound, replacing depleted medical plants. In this study, the endophytes associated with Dysosma difformis-an ethnomedicinal plant species were ...
Hoa Thi Tran, Giang Thu Nguyen, Hong Ha Thi Nguyen, Huyen Thi Tran, Quang Hong Tran, Quang Ho Tran, Ngoc Thi Ninh, Phat Tien Do, Ha Hoang Chu, Ngoc Bich Pham   +9 more
doaj   +1 more source

Uncovering the Key Factors Influencing Phytochemical and Phytopharmacological Properties During Medicinal Plant Processing

eFood, Volume 7, Issue 1, February 2026.
From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
wiley   +1 more source

A Novel Cytotoxic Conjugate Derived from the Natural Product Podophyllotoxin as a Direct-Target Protein Dual Inhibitor

Molecules, 2020
Natural products are the ideal basis for the design of novel efficient molecular entities. Podophyllotoxin, a naturally occurring cyclolignan, is an example of natural product which displays a high versatility from a biological activity point of view ...
Ángela-Patricia Hernández, Paula Díez, Pablo A. García, Martín Pérez-Andrés, Pablo Ortega, Pablo G. Jambrina, David Díez, María Ángeles Castro, Manuel Fuentes   +8 more
doaj   +1 more source

Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins

Molecules, 2022
Plants containing podophyllotoxin and its analogues have been used as folk medicines for centuries. The characteristic chemical structures and strong biological activities of this class of compounds attracted attention worldwide.
Lu Jin, Zhijun Song, Fang Cai, Lijun Ruan, Renwang Jiang   +4 more
doaj   +1 more source

Probing the Binding Site of Abl Tyrosine Kinase Using in Situ Click Chemistry [PDF]

, 2013
Modern combinatorial chemistry is used to discover compounds with desired function by an alternative strategy, in which the biological target is directly involved in the choice of ligands assembled from a pool of smaller fragments. Herein, we present the
Anna Lucia Fallacara, Cristina Peruzzotti, Cristina Tintori, Damiano Monticelli, Daniele Passarella, Gaia Fumagalli, Marcello Luzzani, Maurizio Botta, Michael S. Christodoulou, Micol Ventura, Rebecca Pantano, Stella Borrelli   +11 more
core   +1 more source