Results 51 to 60 of about 8,560 (165)

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Spectroscopic and Molecular Docking Studies on DNA Binding Interaction of Podophyllotoxin [PDF]

Journal of Sciences, Islamic Republic of Iran, 2018
The binding interaction of novel podophyllotoxin derivative, (3R,4R)-4-((benzo[d][1,3]dioxol-5-yl)methyl)-dihydro-3-(hydroxy(3,4-dimethoxyphenyl) methyl) furan-2(3H)-one (PPT), with calf thymus DNA (ctDNA) has been examined using UV-Visible absorption ...
B. Heidary Alizadeh, Gh. Dehghan, V. Derakhsh Ahmadi, S. Moghimi, A. Asadipour, A. Foroumadi   +5 more
doaj   +1 more source

Podophyllin in dermatology: Revisiting a historical drug

Indian Dermatology Online Journal, 2022
Podophyllin is a cytotoxic material extracted from Podophyllum peltatum and Podophyllum hexandrum and is widely used for the treatment of genital warts. This article reviews the chemistry of podophyllin and its active components along with the mechanism ...
Ajeet Singh, Ritul Choudhary, Satyaki Ganguly   +2 more
doaj   +1 more source

The role of phenolic compounds in the fight against cancer – a review [PDF]

, 2013
Cancer is a worldwide scourge; it’s the leading cause of death in developed countries and is increasing in developing countries. Mankind has been trying with effort to find better and cheaper treatments with fewer side effects, to reduce the incidence of
Carocho, Márcio, Ferreira, Isabel C.F.R.   +1 more
core   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Insight Into the Molecular Mechanism of Podophyllotoxin Derivatives as Anticancer Drugs

Frontiers in Cell and Developmental Biology, 2021
Podophyllotoxin (PTOX) is a biologically active compound derived from the podophyllum plant, and both it and its derivatives possess excellent antitumor activity. The PTOX derivatives etoposide (VP-16) and teniposide (VM-26) have been approved by the U.S.
Hua-yang Fan, Zhuo-li Zhu, Hong-chun Xian, Hao-fan Wang, Bing-jun Chen, Ya-Jie Tang, Ya-ling Tang, Xin-hua Liang   +7 more
doaj   +1 more source

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.
ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg   +4 more
wiley   +1 more source

Effect of Some Phytohormones on Podophyllotoxin Production in Cell and Plantlets Cultures of Linum album [PDF]

Journal of Medicinal Plants and By-products, 2013
The natural lignan podophyllotoxin, a dimerized product of two phenylpropanoid moieties which occurs in a few plant species, is a pharmacologically important compound for its anticancer activities.
doaj  

Combined In Vitro Studies and in Silico Target Fishing for the Evaluation of the Biological Activities of Diphylleia cymosa and Podophyllum hexandrum

Molecules, 2018
This paper reports the in silico prediction of biological activities of lignans from Diphylleia cymosa and Podophyllum hexandrum combined with an in vitro bioassays.
Marina Pereira Rocha, Priscilla Rodrigues Valadares Campana, Denise de Oliveira Scoaris, Vera Lucia de Almeida, Julio Cesar Dias Lopes, Julian Mark Hugh Shaw, Claudia Gontijo Silva   +6 more
doaj   +1 more source

Pd(II) Complexes of Schiff Base Ligands Derived From 4‐Aminoantipyrine: Synthesis, Characterization, Crystal Structure and Acute Toxicity Evaluation

ChemistrySelect, Volume 11, Issue 1, 8 January 2026.
Palladium(II) complexes (1–6) with Schiff bases (HL1–HL6) were synthesized and characterized using different spectroscopic methods. The molecular structures of ligands HL1, HL3, HL6 and complexes 1, 2, 3, 6 were determined by X‐ray diffraction analysis. The toxicity of the compounds was assessed on both plant and animal cells.
Andreea Elena Ștefan, Cristina Elena Dinu‐Pîrvu, Sergiu Shova, Ștefania Felicia Bărbuceanu, Teodora Venera Apostol, Rica Boscencu, Diana Carolina Ilieș, Mihaela Badea, Mihaela Dinu, Robert Viorel Ancuceanu, Doina Drăgănescu, Elena Pahonțu   +11 more
wiley   +1 more source