Results 61 to 70 of about 8,560 (165)

Target Analysis and Mechanism of Podophyllotoxin in the Treatment of Triple-Negative Breast Cancer

Frontiers in Pharmacology, 2020
BackgroundAs the original compound of many podophyllotoxin derivatives, podophyllotoxin has a beneficial antitumor effect. The mechanism of podophyllotoxin activity in triple-negative breast cancer still needs to be explored.MethodsWe used cell ...
Wenfeng Zhang, Cun Liu, Jie Li, Ruijuan Liu, Jing Zhuang, Fubin Feng, Yan Yao, Changgang Sun   +7 more
doaj   +1 more source

Treatment for Anogenital Molluscum Contagiosum [PDF]

, 2009
There is no evidence from comparative trials to suggest a single best treatment method for anogenital molluscum contagiosum. Randomized controlled trials suggest self-administered topical imiquimod or podophyllotoxin cream is effective for resolving ...
Brown, Michelle R., Henry, Susan L., Paulson, Christopher P.   +2 more
core  

Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp. [PDF]

, 2009
The biotrasformation of the tetrahydrofuran lignan, (-)-grandisin, by the endophitic fungus Phomopsis sp, obtained from Viguiera arenaria, led to the formation of a new compound determined as 3,4-dimethyl-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-5-methoxy ...
ARAKAWA, Nilton S., CARVALHO, Ivone, KATO, Massuo J., LOPES, Norberto P., PUPO, Mônica T., SAID, Suraia, VERZA, Michelle   +6 more
core   +1 more source

Plant Immunity–Activating Endophytic Bacteria Induce Dynamic Metabolic Changes in Cultured Plant Cells Without Inhibiting Their Growth

Microbial Biotechnology, Volume 19, Issue 1, January 2026.
‘Plant immunity–activating endophytic bacteria’ induce dynamic metabolic changes in cultured plant cells without inhibiting their growth. Co‐culture of plant cells with these bacteria has great potential for the production of valuable phytochemicals.
Yui Aikawa, Ayano Yabuuchi, Hiroki Kaneko, Takafumi Hashimoto, Kazuyuki Kuchitsu, Toshiki Furuya   +5 more
wiley   +1 more source

Topical Podophyllin And Podophyllotoxin For Treatments Of Genital Warts : A Comparative Study

Indian Journal of Dermatology, 2003
The efficacy of podophllin and podophyllotoxin was compared in the treatment of genital warts in 72 men. Thirty five men in group A were treated with 20% podophyllin in tincture benzoin compound at weekly intervals while 37 men in group B were ...
Kar P K, Rajagopal R, Murthy P S
doaj  

Synthesis and Evaluation of New Podophyllotoxin Derivatives with in Vitro Anticancer Activity

Molecules, 2015
A series of novel podophyllotoxin derivatives were designed and synthesized. The cytotoxic activities of these compounds were tested against three tumor cell lines (HeLa, K562, and K562/A02).
Wei-Hua Cheng, Hai Shang, Cong Niu, Zhong-Heng Zhang, Li-Ming Zhang, Hong Chen, Zhong-Mei Zou   +6 more
doaj   +1 more source

Computational Simulation of the Bioactivity of Selected Compounds Derived From the Sapium and Salvias Genera as Anticancer Agents

BioMed Research International, Volume 2026, Issue 1, 2026.
The investigation into the anticancer properties of plant extracts, which are known to be effective therapeutic agents with minimal side effects, is gaining significant traction. The current study examined the bioactive compounds extracted from Sapium ellipticum and Salvia miltiorrhiza Bunge.
Russell B. O. Ouma, Usama Raza, Silas M. Ngari, Joshua K. Kibet, Uzair Nisar, Muhammad Waqar Ali, Baisakhi Banerjee   +6 more
wiley   +1 more source

Multitarget Drugs: an Epigenetic Epiphany [PDF]

, 2016
Epigenetics refers to changes in a biological phenotype that are not due to an underlying change in genotype. In eukaryotes, epigenetics involves a set of chemical modifications of the DNA and the histone proteins in nucleosomes.
Atkinson, Baell, Baud, Beckers, Bentley, Blagodatski, Borretto, Bowman, Brand, Burg, Cai, Chen, Chen, Chen, Chen, Ciceri, Dancy, Deans, Fahy, Filippakopoulos, Finley, Fischer, Fuhrmann, Galloway, Gjertsen, Griffith, Guerrant, Guerrant, Hantschel, He, Huang, Hui, Hurley, Jing, Kaniskan, Kingston, Ko, Kortüm, Kozikowski, Lamblin, Lan, Ling, Liu, Lu, Lu, Maes, Mahboobi, Mahboobi, Mai, McGinty, McPherson, Micelli, Moore, Mottamal, Pachaiyappan, Pastor, Patel, Pereira, Pińa, Qian, Rask-Andersen, Rose, Rothbart, Rotili, Saijo, Saijo, Samatar, Schapira, Suganuma, Tavera-Mendoza, Villalba, Wagner, Winter, Wright, Yu, Yuan, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zuo, Álvarez   +84 more
core   +1 more source

Overview of acute Chinese medicine poisoning in Hong Kong

Hong Kong Journal of Emergency Medicine, Volume 32, Issue 6, December 2025.
Abstract Background Chinese medicine (CM) poisoning is relatively rare in Hong Kong. According to the Department of Health, only 17 cases of self‐medicated Traditional Chinese Medicine (TCM)‐related poisoning were reported between 2019 and 2021—an average of approximately 5.7 cases per year.
Siu Kan Law, Yanping Wang, Xiao Xiao Wu
wiley   +1 more source

Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4β-Triazole Rings

Molecules, 2013
A series of 4β-triazole-linked glucose podophyllotoxin conjugates have been designed and synthesized by employing a click chemistry approach. All the compounds were evaluated for their anticancer activity against a panel of five human cancer cell lines ...
Cheng-Ting Zi, Feng-Qing Xu, Gen-Tao Li, Yan Li, Zhong-Tao Ding, Jun Zhou, Zi-Hua Jiang, Jiang-Miao Hu   +7 more
doaj   +1 more source