Results 71 to 80 of about 8,560 (165)

Chemical Composition and Cytotoxicity Evaluation of Essential Oil from Leaves of Casearia Sylvestris, Its Main Compound alpha-Zingiberene and Derivatives [PDF]

, 2013
Casearia sylvestris (Salicaceae), popularly known as guacatonga, is a plant widely used in folk medicine to treat various diseases, including cancer.
Bou, Diego Dinis, Figueiredo, Carlos Rogerio, Guadagnin, Rafael Carlos, Lago, Joao Henrique Ghilardi, Matsuo, Alisson Leonardo, Sartorelli, Patricia, Soares, Marisi Gomes   +6 more
core   +1 more source

Polyethylene Glycol‐Functionalized Graphene Oxide Nanocomposites: Advances in Biomedical Applications

Nano Select, Volume 6, Issue 12, December 2025.
Polyethylene glycol‐functionalized graphene oxide (PEG‐GO) nanocomposites revolutionize nanomedicine with their high surface area and tunable properties. This review explores their synthesis, characterization, and applications in drug delivery, gene therapy, biosensing, and photothermal therapy.
Oluwasegun Chijioke Adekoya, Gbolahan Joseph Adekoya, Williams Kehinde Kupolati, Yskandar Hamam, Rotimi Emmanuel Sadiku   +4 more
wiley   +1 more source

STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G2 Arrest in the Absence of DNA Damage [PDF]

, 2013
STK295900, a small synthetic molecule belonging to a class of symmetric bibenzimidazoles, exhibits antiproliferative activity against various human cancer cell lines from different origins.
A Balmain, A Satyanarayana, AK Larsen, AW Murray, AY Chen, B Clifford, B Narasimhan, Bo Yeon Kim, BY Kim, CC Chiu, CS Downes, DR Kellogg, DV Bulavin, EA Nigg, EP Rogakou, F Foijer, F Hans, H van Attikum, J Bartek, J Bonnet, J Mann, J Pines, J Rudolph, Jae-Hyuk Jang, JH Trembley, Jian-Ting Zhang, JJ Bower, JJ Champoux, JL Nitiss, Jong Seog Ahn, K Kristjansdottir, K Uto, Krisada Sakchaisri, Kyung Sang Lee, L Antoni, L He, MA Jordan, Nak Kyun Soung, PA Futreal, Raymond Leo Erikson, RT Abraham, S Jin, S Patel, SM Vos, Sun-Ok Kim, Thimmegowda N. R., VA Smits, WM Bonner, WR Taylor, X Cai, Y Pommier, Y Shiloh, Y Wei, YH Hsiang, Yong Tae Kwon, Young Sang Kim, YP Tsao, Yukihiro Asami   +57 more
core   +7 more sources

Synthesis and anticancer activity of dimeric podophyllotoxin derivatives

Drug Design, Development and Therapy, 2018
Cheng-Ting Zi,1–3,* Liu Yang,2,* Feng-Qing Xu,2 Fa-Wu Dong,2 Dan Yang,2 Yan Li,2 Zhong-Tao Ding,3 Jun Zhou,2 Zi-Hua Jiang,4 Jiang-Miao Hu2 1Key Laboratory of Pu-er Tea Science, Ministry of Education, College of Science, Yunnan Agricultural ...
Zi C, Yang L, Xu F, Dong F, Yang D, Li Y, Ding Z, Zhou J, Jiang Z, Hu J   +9 more
doaj  

Evaluation of thermal-stress on the accumulation of podophyllotoxin in shoot in vitro cultures of Linum persicum [PDF]

Research Journal of Pharmacognosy, 2014
Linum persicum is an endangered plant native to Iran, from Linaceae family. Phytochemical analysis has shown that L. persicum in vitro cultures contain podophyllotoxin (PTOX), the pharmacological precursor for anticancer drugs such as etoposide ...
H. Bamfarahnak, A. Gholami, Z. Bakzadeh Bakzadeh, A. Hamedi, A. Mohagheghzadeh   +4 more
doaj  

Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds

ChemMedChem, Volume 20, Issue 21, November 6, 2025.
Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis, Gemma K. Kinsella, James F. Curtin, Tao Zhang   +3 more
wiley   +1 more source

Podophyllotoxin-Loaded Nanostructured Lipid Carriers for Skin Targeting: In Vitro and In Vivo Studies

Molecules, 2016
Nanostructured lipid carriers (NLC) exhibit high skin targeting efficiency and good safety. They are promising vehicles for topical drug delivery. This study aims to increase the skin distribution of podophyllotoxin (POD) by incorporating it into NLCs ...
Jihui Zhao, Xianghua Piao, Xiaoqin Shi, Aiyong Si, Yongtai Zhang, Nianping Feng   +5 more
doaj   +1 more source

Растения, содержащие подофиллотоксин [PDF]

, 2012
Обзор посвящен имеющимся в современной научной литературе данным о растениях, накапливающих ...
Коновалов, Д. А., Мурадханов, Р. Р.   +1 more
core   +1 more source

Comparative proteome analysis and thermal stress induced changes in the embryo of poly- and bi-voltine strains of Bombyx mori [PDF]

, 2017
Proteins are the ultimate operating molecules producing the physiological effect in all the stages of an organism. As a consequence, proteome of the embryo play a pivotal role in determining the biological structures besides cellular organization and ...
Bhat, Muzafer A., Manjunatha, H. B., Punyavathi   +2 more
core   +1 more source

Cytotoxicity of Atropisomeric [1,1′‐Binaphthalene]‐2,2′‐Diamines (BINAM) and Analogs in Human Cancer Cells: Enantioselectivity, Structure–Activity Relationships, and Mechanism

ChemMedChem, Volume 20, Issue 19, October 6, 2025.
It is reported for the first time that atropisomeric (R)‐[1,1′‐binaphthalene]‐2,2′‐diamine (R‐BINAM, 1(R)), but not (S)‐[1,1′‐binaphthalene]‐2,2′‐diamine (S‐BINAM, 1(S)), is a moderately potent spindle poison, causing antiproliferation, depolymerization of microtubules, multipolar spindles, pericentriolar material (PCM) fragmentation, mitotic ...
Malte Eichelbaum, Patrick J. Bednarski
wiley   +1 more source