Podoplanin in Inflammation and Cancer [PDF]
International Journal of Molecular Sciences, 2019 Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the development of the alveoli, heart, and lymphatic vascular system.
M. Quintanilla +3 more
semanticscholar +6 more sources
Targeting Podoplanin for the Treatment of Osteosarcoma
Clinical Cancer Research, 2022 Purpose: Osteosarcoma, the most common bone malignancy in children, has a poor prognosis, especially when the tumor metastasizes to the lungs. Therefore, novel therapeutic strategies targeting both proliferation and metastasis of osteosarcoma are ...
Ai Takemoto +19 more
semanticscholar +3 more sources
Podoplanin drives dedifferentiation and amoeboid invasion of melanoma [PDF]
iScience, 2021 Summary: Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. Melanoma cells utilize amoeboid migration as mode of local invasion. Amoeboid invasion is characterized by rounded cell morphology and
Charlotte M. de Winde +12 more
doaj +4 more sources
Prognostic Value of Podoplanin in Various Tumors [PDF]
Technology in Cancer Research & Treatment, 2021 Background: The prognostic significance of podoplanin (PDPN) in tumor cells for cancer patients’ survival remains controversial. Therefore, we performed this meta-analysis to clarify the relationship between the podoplanin-positive tumor cells and cancer
Xiaohang Wang PhD +9 more
doaj +3 more sources
Elevated Serum Podoplanin Levels Correlate with Disease Severity and Inflammation in Ulcerative Colitis: A Cross-Sectional Study [PDF]
Journal of Inflammation ResearchXiaogang Huang,1 Caifang Tang2 1Department of Gastroenterology, Sijing Hospital, Shanghai, 201601, People’s Republic of China; 2Department of Nursing, Sijing Hospital, Shanghai, 201601, People’s Republic of ChinaCorrespondence: Caifang Tang, Department ...
Huang X, Tang C
doaj +2 more sources
Podoplanin Expression in Early-Stage Colorectal Cancer-Associated Fibroblasts and Its Utility as a Diagnostic Marker for Colorectal Lesions [PDF]
Cells(Background) Cancer-associated fibroblasts (CAFs) are major cancer stromal components. CAFs have diverse functions and cell origins. Podoplanin (PDPN), a lymphatic vessel marker, is also a CAF marker in certain cancers.
Shuichi Tsukamoto +6 more
doaj +2 more sources
Immunohistochemical evaluation of podoplanin in odontogenic tumours & cysts using anti-human podoplanin antibody [PDF]
Journal of Oral Biology and Craniofacial Research, 2017 Background: Odontogenic Cysts & tumors originate through some aberration from the normal pattern of odontogenesis. Ameloblastoma is one of the most frequent intraosseous odontogenic tumors.
Namrata Singhal +5 more
doaj +3 more sources
Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma [PDF]
Frontiers in ImmunologyIntroductionMelanoma is a highly immunogenic and aggressive malignancy characterized by pronounced intratumoral lymphocytic infiltration and significant responsiveness to immunotherapeutic interventions.
Chunyan Feng +5 more
doaj +2 more sources
Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma [PDF]
JTO Clinical and Research ReportsIntroduction: Resistance to EGFR tyrosine kinase inhibitors is influenced by tumor-intrinsic and -extrinsic factors. We investigated the impact of tumor cell histology and tumor microenvironment on the efficacy of osimertinib.
Yuji Uehara, MD +19 more
doaj +2 more sources