Results 11 to 20 of about 19,338 (290)

Targeting Podoplanin for the Treatment of Osteosarcoma

Clinical Cancer Research, 2022
Purpose: Osteosarcoma, the most common bone malignancy in children, has a poor prognosis, especially when the tumor metastasizes to the lungs. Therefore, novel therapeutic strategies targeting both proliferation and metastasis of osteosarcoma are ...
Ai Takemoto, S. Takagi, Takao Ukaji, N. Gyobu, M. Kakino, Miho Takami, Asami Kobayashi, Marie Lebel, T. Kawaguchi, M. Sugawara, K. Tsuji‐Takayama, K. Ichihara, Y. Funauchi, K. Ae, S. Matsumoto, Yoshiya Sugiura, K. Takeuchi, T. Noda, Ryohei Katayama, Naoya Fujita   +19 more
semanticscholar   +3 more sources

Roles of Podoplanin in Malignant Progression of Tumor [PDF]

Cells, 2022
Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor development and normal development of the lung, kidney, and lymphatic vascular systems.
Hiroyuki Suzuki, M. Kaneko, Y. Kato
semanticscholar   +4 more sources

Podoplanin in Inflammation and Cancer [PDF]

International Journal of Molecular Sciences, 2019
Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the development of the alveoli, heart, and lymphatic vascular system.
M. Quintanilla, Lucía Montero-Montero, J. Renart, Ester Martín-Villar   +3 more
semanticscholar   +7 more sources

The spectrum of podoplanin expression in encapsulating peritoneal sclerosis. [PDF]

PLoS ONE, 2012
Encapsulating peritoneal sclerosis (EPS) is a life threatening complication of peritoneal dialysis (PD). Podoplanin is a glycoprotein expressed by mesothelial cells, lymphatic endothelial cells, and myofibroblasts in peritoneal biopsies from patients ...
Niko Braun, M Dominik Alscher, Peter Fritz, Joerg Latus, Ilka Edenhofer, Fabian Reimold, Seth L Alper, Martin Kimmel, Dagmar Biegger, Maja Lindenmeyer, Clemens D Cohen, Rudolf P Wüthrich, Stephan Segerer   +12 more
doaj   +7 more sources

Podoplanin drives dedifferentiation and amoeboid invasion of melanoma [PDF]

iScience, 2021
Summary: Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. Melanoma cells utilize amoeboid migration as mode of local invasion. Amoeboid invasion is characterized by rounded cell morphology and
Charlotte M. de Winde, Samantha L. George, Eva Crosas-Molist, Yukti Hari-Gupta, Abbey B. Arp, Agnesska C. Benjamin, Lindsey J. Millward, Spyridon Makris, Alexander Carver, Valerio Imperatore, Víctor G. Martínez, Victoria Sanz-Moreno, Sophie E. Acton   +12 more
doaj   +5 more sources

The multifaceted role of podoplanin expression in hepatocellular carcinoma

European Journal of Histochemistry, 2017
The role of podoplanin in hepatocellular carcinoma (HCC) is not clear yet. The aim of our study was to evaluate the expression of podoplanin in HCC and to determine its role in hepatocarcinogenesis. We performed immunohistochemistry with monoclonal D2-40
Andreea Cioca, Amalia R. Ceausu, Irina Marin, Marius Raica, Anca M. Cimpean   +4 more
doaj   +5 more sources

Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma [PDF]

JTO Clinical and Research Reports
Introduction: Resistance to EGFR tyrosine kinase inhibitors is influenced by tumor-intrinsic and -extrinsic factors. We investigated the impact of tumor cell histology and tumor microenvironment on the efficacy of osimertinib.
Yuji Uehara, MD, Hiroki Izumi, MD, PhD, Tetsuro Taki, MD, PhD, Tetsuya Sakai, MD, PhD, Hibiki Udagawa, MD, PhD, Eri Sugiyama, MD, PhD, Shigeki Umemura, MD, PhD, Yoshitaka Zenke, MD, PhD, Shingo Matsumoto, MD, PhD, Kiyotaka Yoh, MD, PhD, Shoko Kubota, MD, PhD, Keiju Aokage, MD, PhD, Naoya Sakamoto, MD, PhD, Shingo Sakashita, MD, PhD, Motohiro Kojima, MD, PhD, Michiko Nagamine, MD, PhD, Yukio Hosomi, MD, PhD, Masahiro Tsuboi, MD, PhD, Koichi Goto, MD, PhD, Genichiro Ishii, MD, PhD   +19 more
doaj   +2 more sources

Immunohistochemical evaluation of podoplanin in odontogenic tumours & cysts using anti-human podoplanin antibody [PDF]

Journal of Oral Biology and Craniofacial Research, 2017
Background: Odontogenic Cysts & tumors originate through some aberration from the normal pattern of odontogenesis. Ameloblastoma is one of the most frequent intraosseous odontogenic tumors.
Namrata Singhal, Nitin Khanduri, Deepak Kurup, Brijesh Gupta, Pranjan Mitra, Roshani Chawla   +5 more
doaj   +4 more sources

Study of Podoplanin-Deficient Mouse Bone with Mechanical Stress [PDF]

Dentistry Journal
Objective: We investigated morphological differences in osteocyte processes between aged mice and our original podoplanin-conditional knockout (cKO) mice in which the floxed exon 3 of podoplanin was deleted by Dmp-1-driven Cre (Dmp1-Cre;PdpnΔ/Δ). Methods:
Takenori Kanai, Kyoko Osawa, Koichiro Kajiwara, Yoshiaki Sato, Yoshihiko Sawa   +4 more
doaj   +2 more sources

The potential role of podoplanin in tumour invasion [PDF]

British Journal of Cancer, 2006
Podoplanin is a small mucin-like transmembrane protein, widely expressed in various specialised cell types throughout the body. Here, we revisit the mechanism of podoplanin-mediated tumour invasion. We compare molecular pathways leading to single and collective cell invasion and discuss novel distinct concepts of tumour cell invasion.
Andreas Wicki, Gerhard Christofori
openalex   +3 more sources