Results 21 to 30 of about 13,097 (241)

CLEC-2 and podoplanin, partners again [PDF]

Blood, 2016
In this issue of Blood, Tamura et al reveal a novel function for podoplanin on periarteriolar stromal cells in the bone marrow: promoting megakaryocyte growth and proplatelet formation by interaction with C-type lectin-like receptor 2 (CLEC-2).
Jianxin Fu, Lijun Xia
openalex   +3 more sources

Podoplanin Expression in Canine Melanoma [PDF]

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2016
A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein,
Satoshi Ogasawara, Ryusuke Honma, Mika K. Kaneko, Yuki Fujii, Yumiko Kagawa, Satoru Konnai, Yukinari Kato   +6 more
openalex   +3 more sources

Podoplanin-Positive Fibroblasts Enhance Lung Adenocarcinoma Tumor Formation: Podoplanin in Fibroblast Functions for Tumor Progression [PDF]

Cancer Research, 2011
Abstract During the metastatic process, cancer cells interact with vascular adventitial fibroblasts (VAF), which are the main components of the outermost connective tissue layer of blood vessels. This activity suggests the presence of a specific tumor microenvironment in the perivascular area. The s.c.
Ayuko Hoshino, Genichiro Ishii, Tetsufumi Ito, Kazuhiko Aoyagi, Yoichi Ohtaki, Kanji Nagai, Hiroki Sasaki, Atsushi Ochiai   +7 more
openalex   +4 more sources

Roles of Podoplanin in Malignant Progression of Tumor

Cells, 2022
Podoplanin (PDPN) is a cell-surface mucin-like glycoprotein that plays a critical role in tumor development and normal development of the lung, kidney, and lymphatic vascular systems.
Hiroyuki Suzuki, M. Kaneko, Y. Kato
semanticscholar   +1 more source

The spectrum of podoplanin expression in encapsulating peritoneal sclerosis. [PDF]

PLoS ONE, 2012
Encapsulating peritoneal sclerosis (EPS) is a life threatening complication of peritoneal dialysis (PD). Podoplanin is a glycoprotein expressed by mesothelial cells, lymphatic endothelial cells, and myofibroblasts in peritoneal biopsies from patients ...
Niko Braun, M Dominik Alscher, Peter Fritz, Joerg Latus, Ilka Edenhofer, Fabian Reimold, Seth L Alper, Martin Kimmel, Dagmar Biegger, Maja Lindenmeyer, Clemens D Cohen, Rudolf P Wüthrich, Stephan Segerer   +12 more
doaj   +1 more source

Co-Expression of Podoplanin and CD44 in Proliferative Vitreoretinopathy Epiretinal Membranes

International Journal of Molecular Sciences, 2023
Epiretinal membranes (ERMs) are sheets of tissue that pathologically develop in the vitreoretinal interface leading to progressive vision loss. They are formed by different cell types and by an exuberant deposition of extracellular matrix proteins ...
Denise Bonente, L. Bianchi, R. De Salvo, C. Nicoletti, Elena De Benedetto, Tommaso Bacci, L. Bini, Giovanni Inzalaco, Lorenzo Franci, M. Chiariello, G. Tosi, E. Bertelli, Virginia Barone   +12 more
semanticscholar   +1 more source

Podoplanin: A potential therapeutic target for thrombotic diseases

Frontiers in Neurology, 2023
As a specific lymphatic marker and a key ligand of C-type lectin-like receptor 2 (CLEC-2), podoplanin (Pdpn) is involved in various physiological and pathological processes such as growth and development, respiration, blood coagulation, lymphangiogenesis,
Ya-Qun Huang, Manli Lu, Yi Wang, Chun-yuan Zhang, Yongjun Cao, Xia Zhang   +5 more
semanticscholar   +1 more source

Detection of Lion Podoplanin Using the Antitiger Podoplanin Monoclonal Antibody PMab-231 [PDF]

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2020
Monoclonal antibodies (mAbs) that specifically target podoplanin (PDPN), a marker for type I alveolar cells, are needed for immunohistochemical analyses. Anti-PDPN mAbs are available for many species, including human, mouse, rat, rabbit, dog, cat, bovine, pig, Tasmanian devil, alpaca, tiger, whale, goat, horse, bear, and sheep ...
Yukinari, Kato, Junko, Takei, Masato, Sano, Teizo, Asano, Yusuke, Sayama, Kazuyuki, Uchida, Takayuki, Nakagawa, Mika K, Kaneko   +7 more
openaire   +2 more sources

Morphological study of tooth development in podoplanin-deficient mice. [PDF]

PLoS ONE, 2017
Podoplanin is a mucin-type highly O-glycosylated glycoprotein identified in several somatyic cells: podocytes, alveolar epithelial cells, lymphatic endothelial cells, lymph node stromal fibroblastic reticular cells, osteocytes, odontoblasts, mesothelial ...
Kenyo Takara, Naoki Maruo, Kyoko Oka, Chiaki Kaji, Yuji Hatakeyama, Naruhiko Sawa, Yukinari Kato, Junro Yamashita, Hiroshi Kojima, Yoshihiko Sawa   +9 more
doaj   +1 more source

Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma

Journal of Pathology, 2022
Cancer‐associated fibroblasts (CAFs) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Previously we described four CAF subtypes with specific molecular and functional features.
C. Neuzillet, R. Nicolle, J. Raffenne, Annemilaï Tijeras-Raballand, A. Brunel, Lucile Astorgues-Xerri, S. Vacher, Floriane Arbateraz, M. Fanjul, M. Hilmi, R. Samain, C. Klein, A. Perraud, V. Rebours, M. Mathonnet, I. Bièche, H. Kocher, J. Cros, C. Bousquet   +18 more
semanticscholar   +1 more source