Results 31 to 40 of about 13,097 (241)

Expression of Podoplanin in Laryngeal Squamous Cell Carcinoma and Dysplasia [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: In human cancers, podoplanin expression and its correlation with tumour invasive potential raise its possible role as a diagnostic and prognostic marker for cancer. Aim: To investigate the immunohistochemical expression of podoplanin in
Badawia Bayoumy Ibrahim, Mostafa Mohamed Salem, Rasha Ahmed Khairy, Reema Abdul Rahman AL Gunaid   +3 more
doaj   +1 more source

Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles.

Blood Advances, 2021
Vascular anomalies, including local and peripheral thrombosis, are a hallmark of glioblastoma (GBM) and an aftermath of deregulation of the cancer cell genome and epigenome.
Nadim Tawil, Rayhaan Bassawon, B. Meehan, A. Nehme, Laura Montermini, T. Gayden, Nicolas de Jay, C. Spinelli, S. Chennakrishnaiah, Dongsic Choi, L. Adnani, M. Zeinieh, N. Jabado, C. Kleinman, M. Witcher, Y. Riazalhosseini, N. Key, D. Schiff, S. Grover, N. Mackman, C. Couturier, K. Petrecca, M. Suvà, Anoop P. Patel, I. Tirosh, H. Najafabadi, J. Rak   +26 more
semanticscholar   +1 more source

Improved anti‐solid tumor response by humanized anti‐podoplanin chimeric antigen receptor transduced human cytotoxic T cells in an animal model

Genes to Cells, 2022
Recently, research has been conducted with chimeric antigen receptor (CAR)‐T cells to improve efficacy against solid tumors. Humanized CAR improved the long‐term survival of CAR‐T cells in patients' peripheral blood, resulting in increased therapeutic ...
A. Ishikawa, Masazumi Waseda, T. Ishii, M. Kaneko, Y. Kato, S. Kaneko   +5 more
semanticscholar   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Podoplanin-Fc burns out platelets [PDF]

Blood, 2010
In this issue of Blood, Cueni and colleagues have demonstrated that podoplanin-Fc not only displays an inhibitory effect on lymphatic vessel formation, but also induces platelet aggregation and disseminated intravascular coagulation (DIC) in transgenic mice.
Kim, HS Kim, Hon-Soul, Koh, GY Koh, Gou-Young   +1 more
openaire   +3 more sources

Podoplanin increases the migration of human fibroblasts and affects the endothelial cell network formation: A possible role for cancer-associated fibroblasts in breast cancer progression. [PDF]

PLoS ONE, 2017
In our previous studies we showed that in breast cancer podoplanin-positive cancer-associated fibroblasts correlated positively with tumor size, grade of malignancy, lymph node metastasis, lymphovascular invasion and poor patients' outcome.
Jaroslaw Suchanski, Anna Tejchman, Maciej Zacharski, Aleksandra Piotrowska, Jedrzej Grzegrzolka, Grzegorz Chodaczek, Katarzyna Nowinska, Janusz Rys, Piotr Dziegiel, Claudine Kieda, Maciej Ugorski   +10 more
doaj   +1 more source

Podoplanin promotes tumor growth, platelet aggregation, and venous thrombosis in murine models of ovarian cancer

Journal of Thrombosis and Haemostasis, 2021
Podoplanin (PDPN) is a sialylated membrane glycoprotein that binds to C‐type lectin‐like receptor 2 on platelets resulting in platelet activation. PDPN is expressed on lymphatic endothelial cells, perivascular fibroblasts/pericytes, cancer cells, cancer ...
Tomoyuki Sasano, Ricardo Gonzalez-Delgado, Nina M. Muñoz, Wendolyn Carlos-Alcade, M. Cho, R. Sheth, A. Sood, V. Afshar-Kharghan   +7 more
semanticscholar   +1 more source

The Role of Podoplanin in Skin Diseases [PDF]

The Nishinihon Journal of Dermatology, 2023
Podoplanin is a sialomucin-like type I transmembrane receptor glycoprotein that is expressed specifically in lymphatic vessels, sebaceous glands, and hair follicles in normal skin. However, under pathological conditions podoplanin expression is upregulated in various cells, such as keratinocytes, fibroblasts, tumor cells, and inflammatory cells, and ...
Jun Asai
openalex   +3 more sources

Phenotypically heterogeneous podoplanin-expressing cell populations are associated with the lymphatic vessel growth and fibrogenic responses in the acutely and chronically infarcted myocardium. [PDF]

PLoS ONE, 2017
Cardiac lymphatic vasculature undergoes substantial expansion in response to myocardial infarction (MI). However, there is limited information on the cellular mechanisms mediating post-MI lymphangiogenesis and accompanying fibrosis in the infarcted adult
Maria Cimini, Antonio Cannatá, Gianandrea Pasquinelli, Marcello Rota, Polina Goichberg   +4 more
doaj   +1 more source

Podoplanin could be a predictive biomarker of the risk of patients with oral leukoplakia to develop oral cancer. A systematic review and meta-analysis.

Oral Diseases, 2022
OBJECTIVES To identify and analyze the existing literature on the utility of podoplanin to predict the risk of malignancy development (MD) in patients previously diagnosed with oral leukoplakia (OL). METHODS A systematic review and meta-analysis (SR-MA)
L. Monteiro, Lorena C Mariano, S. Warnakulasuriya   +2 more
semanticscholar   +1 more source