Results 31 to 40 of about 19,338 (290)

Morphological study of tooth development in podoplanin-deficient mice. [PDF]

PLoS ONE, 2017
Podoplanin is a mucin-type highly O-glycosylated glycoprotein identified in several somatyic cells: podocytes, alveolar epithelial cells, lymphatic endothelial cells, lymph node stromal fibroblastic reticular cells, osteocytes, odontoblasts, mesothelial ...
Kenyo Takara, Naoki Maruo, Kyoko Oka, Chiaki Kaji, Yuji Hatakeyama, Naruhiko Sawa, Yukinari Kato, Junro Yamashita, Hiroshi Kojima, Yoshihiko Sawa   +9 more
doaj   +1 more source

Improved anti‐solid tumor response by humanized anti‐podoplanin chimeric antigen receptor transduced human cytotoxic T cells in an animal model

Genes to Cells, 2022
Recently, research has been conducted with chimeric antigen receptor (CAR)‐T cells to improve efficacy against solid tumors. Humanized CAR improved the long‐term survival of CAR‐T cells in patients' peripheral blood, resulting in increased therapeutic ...
A. Ishikawa, Masazumi Waseda, T. Ishii, M. Kaneko, Y. Kato, S. Kaneko   +5 more
semanticscholar   +1 more source

Expression of Podoplanin in Laryngeal Squamous Cell Carcinoma and Dysplasia [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: In human cancers, podoplanin expression and its correlation with tumour invasive potential raise its possible role as a diagnostic and prognostic marker for cancer. Aim: To investigate the immunohistochemical expression of podoplanin in
Badawia Bayoumy Ibrahim, Mostafa Mohamed Salem, Rasha Ahmed Khairy, Reema Abdul Rahman AL Gunaid   +3 more
doaj   +1 more source

Evolutionary history of the podoplanin gene [PDF]

Gene Reports, 2018
JR and MQ were supported by grant SAF2013-46183-R from the Ministerio de Economía y Competitividad, Spain. AA and DSM were financed by grant CGL2012-40082, and DSM also supported by grant RYC-2011-09321, both from the Ministerio de Economía y Competitividad, Spain.
Jaime Renart, Diego San Mauro, Ainhoa Agorreta, Kim Rutherford, Neil J. Gemmell, Miguel Quintanilla   +5 more
openaire   +3 more sources

Thr80 of Sheep Podoplanin Is a Critical Epitope of the Antisheep Podoplanin Monoclonal Antibody: PMab-256 [PDF]

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2020
An antisheep podoplanin (sPDPN) monoclonal antibody (mAb), PMab-256, has recently been established. PMab-256 shows positive immunostaining for lymphatic endothelial cells, lung type I alveolar cells, and kidney podocytes. PDPN possesses three platelet-aggregation-stimulating (PLAG) domains, PLAG1, PLAG2, and PLAG3, and a PLAG-like domain (PLD).
Teizo Asano, Yusuke Sayama, Mika K. Kaneko, Masato Sano, Yukinari Kato   +4 more
openaire   +3 more sources

Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma

Journal of Pathology, 2022
Cancer‐associated fibroblasts (CAFs) are orchestrators of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Previously we described four CAF subtypes with specific molecular and functional features.
C. Neuzillet, R. Nicolle, J. Raffenne, Annemilaï Tijeras-Raballand, A. Brunel, Lucile Astorgues-Xerri, S. Vacher, Floriane Arbateraz, M. Fanjul, M. Hilmi, R. Samain, C. Klein, A. Perraud, V. Rebours, M. Mathonnet, I. Bièche, H. Kocher, J. Cros, C. Bousquet   +18 more
semanticscholar   +1 more source

Podoplanin Expression in Canine Melanoma [PDF]

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2016
A type I transmembrane protein, podoplanin (PDPN), is expressed in several normal cells such as lymphatic endothelial cells or pulmonary type I alveolar cells. We recently demonstrated that anticanine PDPN monoclonal antibody (mAb), PMab-38, recognizes canine PDPN of squamous cell carcinomas, but does not react with lymphatic endothelial cells. Herein,
Ryusuke Honma, Yumiko Kagawa, Satoru Konnai, Yuki Fujii, Mika K. Kaneko, Yukinari Kato, Satoshi Ogasawara   +6 more
openaire   +3 more sources

Podoplanin is Responsible for the Distinct Blood and Lymphatic Capillaries

Cellular and Molecular Bioengineering, 2022
Controlling the formation of blood and lymphatic vasculatures is crucial for engineered tissues. Although the lymphatic vessels originate from embryonic blood vessels, the two retain functional and physiological differences even as they develop in the ...
Donghyun Paul Jeong, Eva Hall, Erin Neu, Donny Hanjaya‐Putra   +3 more
semanticscholar   +1 more source

Integration of Primary Murine Osteocytes for In Vitro Mechanobiology Studies. [PDF]

Curr Protoc
Abstract This article describes the isolation, culture, and integration of primary murine osteocytes on a microfluidic platform for in vitro mechanobiology studies. Osteocytes are mechanosensitive cells embedded within the bone matrix and regulate bone remodeling. The MLO‐Y4 osteocyte‐like cell line typically used for mechanobiology studies can provide
Seaman K, Lin CY, Song X, Sassi A, Du WW, Sun Y, Yang B, You L.   +7 more
europepmc   +2 more sources

Podoplanin increases the migration of human fibroblasts and affects the endothelial cell network formation: A possible role for cancer-associated fibroblasts in breast cancer progression. [PDF]

PLoS ONE, 2017
In our previous studies we showed that in breast cancer podoplanin-positive cancer-associated fibroblasts correlated positively with tumor size, grade of malignancy, lymph node metastasis, lymphovascular invasion and poor patients' outcome.
Jaroslaw Suchanski, Anna Tejchman, Maciej Zacharski, Aleksandra Piotrowska, Jedrzej Grzegrzolka, Grzegorz Chodaczek, Katarzyna Nowinska, Janusz Rys, Piotr Dziegiel, Claudine Kieda, Maciej Ugorski   +10 more
doaj   +1 more source