Results 41 to 50 of about 19,338 (290)

Phenotypically heterogeneous podoplanin-expressing cell populations are associated with the lymphatic vessel growth and fibrogenic responses in the acutely and chronically infarcted myocardium. [PDF]

PLoS ONE, 2017
Cardiac lymphatic vasculature undergoes substantial expansion in response to myocardial infarction (MI). However, there is limited information on the cellular mechanisms mediating post-MI lymphangiogenesis and accompanying fibrosis in the infarcted adult
Maria Cimini, Antonio Cannatá, Gianandrea Pasquinelli, Marcello Rota, Polina Goichberg   +4 more
doaj   +1 more source

Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles.

Blood Advances, 2021
Vascular anomalies, including local and peripheral thrombosis, are a hallmark of glioblastoma (GBM) and an aftermath of deregulation of the cancer cell genome and epigenome.
Nadim Tawil, Rayhaan Bassawon, B. Meehan, A. Nehme, Laura Montermini, T. Gayden, Nicolas de Jay, C. Spinelli, S. Chennakrishnaiah, Dongsic Choi, L. Adnani, M. Zeinieh, N. Jabado, C. Kleinman, M. Witcher, Y. Riazalhosseini, N. Key, D. Schiff, S. Grover, N. Mackman, C. Couturier, K. Petrecca, M. Suvà, Anoop P. Patel, I. Tirosh, H. Najafabadi, J. Rak   +26 more
semanticscholar   +1 more source

Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization,secondary mediators, and Rac [PDF]

, 2010
The C-type lectin-like receptor 2 (CLEC-2)activates platelets through Src and Syk tyrosine kinases via a single cytoplasmic YxxL motif known as a hem immunoreceptor tyrosine-based activation motif (hemITAM).Here, we demonstrate using sucrose gradient ...
Alice Y. Pollitt, Atkinson, Barrow, Beata Grygielska, Bertrand Leblond, Bodin, Bodin, Boggon, Christou, Colonna, Eble, Ezumi, Fuller, He, Hooley, Hughes, Huysamen, Johannes A. Eble, Kerrigan, Laurent Désiré, Lee, Locke, May, McCarty, Pestina, Piechulek, Pierce, Pleines, Quek, Sancho, Schacht, Shutes, Simons, Sobanov, Spalton, Steve P. Watson, Suzuki-Inoue, Suzuki-Inoue, Tolias, Walliser, Watson, Watson, Wonerow, Wonerow, Xu   +44 more
core   +1 more source

The Role of Podoplanin in Skin Diseases

International Journal of Molecular Sciences, 2022
Podoplanin is a sialomucin-like type I transmembrane receptor glycoprotein that is expressed specifically in lymphatic vessels, sebaceous glands, and hair follicles in normal skin.
J. Asai
semanticscholar   +1 more source

RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]

, 2016
Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia, Boichard, Amélie, Casadei, Gian Piero, Checquolo, Saula, Colato, Chiara, de Biase, Dario, Durante, Cosimo, Ferdeghini, Marco, Filetti, Sebastiano, Pecce, Valeria, Rhoden, Kerry, Rosignolo, Francesca, Russo, Diego, Sponziello, Marialuisa, Tallini, Giovanni, Verrienti, Antonella, Visani, Michela   +16 more
core   +1 more source

Podoplanin promotes tumor growth, platelet aggregation, and venous thrombosis in murine models of ovarian cancer

Journal of Thrombosis and Haemostasis, 2021
Podoplanin (PDPN) is a sialylated membrane glycoprotein that binds to C‐type lectin‐like receptor 2 on platelets resulting in platelet activation. PDPN is expressed on lymphatic endothelial cells, perivascular fibroblasts/pericytes, cancer cells, cancer ...
Tomoyuki Sasano, Ricardo Gonzalez-Delgado, Nina M. Muñoz, Wendolyn Carlos-Alcade, M. Cho, R. Sheth, A. Sood, V. Afshar-Kharghan   +7 more
semanticscholar   +1 more source

Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer [PDF]

, 2019
Aims Lymphovascular space invasion (LVSI) in endometrial cancer (EC) is an important prognostic variable impacting on a patient's individual recurrence risk and adjuvant treatment recommendations.
Bartosch, Carla, Bosse, Tjalling, Genestie, Catherine, Lax, Sigurd F, McCluggage, W Glenn, Nout, Remi, Oosting, Jan, Peters, Elke E M, Singh, Naveena, Smit, Huub C S H, Smit, Vincent T H B M, Van de Vijver, Koen   +11 more
core   +2 more sources

The landscape of ‘podoplanin’ in dermatology

Journal of the Egyptian Women's Dermatologic Society, 2021
Podoplanin (PDPN) is a specific marker for lymphatic endothelial cells; however, it can be expressed by many other cells including renal podocytes. In dermatology, PDPN has been involved in diverse disorders, such as tumor lymphangiogenesis, as well as in immune-mediated disorders.
Nagwa Diab, Nourhan Anis, Magda Assaf, Eman Salah   +3 more
openaire   +3 more sources

Podoplanin in cancer cells is experimentally able to attenuate prolymphangiogenic and lymphogenous metastatic potentials of lung squamoid cancer cells

Molecular Cancer, 2010
Background Podoplanin, a mucin-like transmembrane glycoprotein, is reportedly expressed in a variety of malignant cells and is generally regarded as a factor for promoting tumor progression in conventional studies.
Suzuki Hanako, Onimaru Mitsuho, Yonemitsu Yoshikazu, Maehara Yoshihiko, Nakamura Seiji, Sueishi Katsuo   +5 more
doaj   +1 more source

Induction of podoplanin by transforming growth factor-β in human fibrosarcoma [PDF]

, 2008
Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential.
Kato Kaneko Mika, Kato Mitsuyasu, Kato Yukinari, Narimatsu Hisashi, Okita Yukari, Suzuki Hiroyuki, 加藤 光保, 鈴木 裕之   +7 more
core   +1 more source