Results 51 to 60 of about 13,097 (241)

Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin.

Blood, 2019
Patients with cancer have an increased risk of thromboembolism, which is the second leading cause of death in these patients. Several mechanisms of the prothrombotic state in these patients have been proposed.
K. Suzuki-Inoue
semanticscholar   +1 more source

Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas

Molecular Cancer, 2010
Background Podoplanin expression is attracting interest as a marker for cancer diagnosis and prognosis. We therefore investigated the expression pattern and clinical significance of podoplanin during the development and progression of laryngeal ...
Fresno Manuel F, Mancebo Gonzalo, González María V, García-Carracedo Dario, Rodrigo Juan P, García-Pedrero Juana   +5 more
doaj   +1 more source

CLEC-2/podoplanin and thromboinflammation [PDF]

Blood, 2017
In this issue of Blood, Payne et al revealed a novel function of the platelet C–type lectin-like receptor 2 (CLEC-2)/podoplanin interaction in thromboinflammation: podoplanin expression is upregulated in the vessel wall during venous thrombosis. Venous thrombosis is prevented in the absence of CLEC-2.1 The role of platelet CLEC-2 in thromboinflammation
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Podoplanin [PDF]

Journal of Neuropathology & Experimental Neurology, 2015
Reactive astrogliosis is associated with many pathologic processes in the central nervous system, including gliomas. The glycoprotein podoplanin (PDPN) is upregulated in malignant gliomas. Using a syngeneic intracranial glioma mouse model, we show that PDPN is highly expressed in a subset of glial fibrillary acidic protein-positive astrocytes within ...
Kushal, Kolar, Moises, Freitas-Andrade, John F, Bechberger, Harini, Krishnan, Gary S, Goldberg, Christian C, Naus, Wun Chey, Sin   +6 more
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Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation

Scientific Reports, 2017
Podoplanin/Aggrus, known as a platelet aggregation-inducing factor, is frequently overexpressed in lung squamous cell carcinomas (LSCC) and glioblastomas among other tumours, and its expression has been reported to be correlated with poor prognosis ...
Kenichi Miyata, Ai Takemoto, Sakae Okumura, Makoto Nishio, Naoya Fujita   +4 more
doaj   +1 more source

Physiological and pathophysiological aspects of blood platelet activation through CLEC-2 receptor

Онкогематология, 2018
Platelet activating receptor CLEC-2 has been identified on platelet surface a decade ago. The only confirmed endogenous CLEC-2 agonist is podoplanin. Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, reticular fibroblastic ...
A. A. Martyanov, V. N. Kaneva, M. A. Panteleev, A. N. Sveshnikova   +3 more
doaj   +1 more source

Platelet CLEC2-Podoplanin Axis as a Promising Target for Oral Cancer Treatment

Frontiers in Immunology, 2021
Cancer tissues are not just simple masses of malignant cells, but rather complex and heterogeneous collections of cellular and even non-cellular components, such as endothelial cells, stromal cells, immune cells, and collagens, referred to as tumor ...
Byeong-Oh Hwang, Se-Young Park, E. Cho, Xianglan Zhang, S. K. Lee, H. Ahn, K. Chun, W. Chung, Na-Young Song   +8 more
semanticscholar   +1 more source

Risking thromboembolism: podoplanin and glioma [PDF]

Blood, 2017
In this issue of Blood , [Riedl et al][1] evaluate the link between tumor podoplanin expression and the prothrombotic state inherent to glioma and find that podoplanin expression is associated with altered markers of coagulation activation and an increased risk of venous thromboembolism.[1][2] ![
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Thr80 of Sheep Podoplanin Is a Critical Epitope of the Antisheep Podoplanin Monoclonal Antibody: PMab-256 [PDF]

Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2020
An antisheep podoplanin (sPDPN) monoclonal antibody (mAb), PMab-256, has recently been established. PMab-256 shows positive immunostaining for lymphatic endothelial cells, lung type I alveolar cells, and kidney podocytes. PDPN possesses three platelet-aggregation-stimulating (PLAG) domains, PLAG1, PLAG2, and PLAG3, and a PLAG-like domain (PLD).
Yukinari, Kato, Masato, Sano, Teizo, Asano, Yusuke, Sayama, Mika K, Kaneko   +4 more
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Cancer-associated fibroblasts expressing fibroblast activation protein and podoplanin in non-small cell lung cancer predict poor clinical outcome

British Journal of Cancer
Cancer-associated fibroblasts (CAFs) are a dominant cell type in the stroma of non-small cell lung cancer (NSCLC). Fibroblast heterogeneity reflects subpopulations of CAFs, which can influence prognosis and treatment efficacy. We describe the subtypes of
Layla Mathieson, Lilian Koppensteiner, David A. Dorward, Richard A O'Connor, A. Akram   +4 more
semanticscholar   +1 more source