Results 51 to 60 of about 19,338 (290)

Roles of the CLEC-2–podoplanin interaction in tumor progression

Platelets, 2018
Podoplanin is a type-I transmembrane sialomucin-like glycoprotein expressed on the surface of several kinds of tumor cells. The podoplanin receptor is a platelet activation receptor known as C-type lectin-like receptor 2 (CLEC-2), which has been ...
Katsue Suzuki-Inoue
doaj   +1 more source

Interplay between Podoplanin, CD44s and CD44v in Squamous Carcinoma Cells

Cells, 2020
Podoplanin and CD44 are transmembrane glycoproteins involved in inflammation and cancer. In this paper, we report that podoplanin is coordinately expressed with the CD44 standard (CD44s) and variant (CD44v) isoforms in vivo—in hyperplastic skin after a ...
Lucía Montero-Montero, Jaime Renart, Andrés Ramírez, Carmen Ramos, Mariam Shamhood, Rocío Jarcovsky, Miguel Quintanilla, Ester Martín-Villar   +7 more
doaj   +1 more source

Risking thromboembolism: podoplanin and glioma [PDF]

Blood, 2017
In this issue of Blood , [Riedl et al][1] evaluate the link between tumor podoplanin expression and the prothrombotic state inherent to glioma and find that podoplanin expression is associated with altered markers of coagulation activation and an increased risk of venous thromboembolism.[1][2] ![
openaire   +3 more sources

Podoplanin could be a predictive biomarker of the risk of patients with oral leukoplakia to develop oral cancer. A systematic review and meta-analysis.

Oral Diseases, 2022
OBJECTIVES To identify and analyze the existing literature on the utility of podoplanin to predict the risk of malignancy development (MD) in patients previously diagnosed with oral leukoplakia (OL). METHODS A systematic review and meta-analysis (SR-MA)
L. Monteiro, Lorena C Mariano, S. Warnakulasuriya   +2 more
semanticscholar   +1 more source

Podoplanin expression in lymph node metastases of head and neck cancer and cancer of unknown primary patients

International Journal of Biological Markers, 2022
Introduction Head and neck squamous cell carcinomas (HNSCCs) are cancers with generally poor prognosis. Outcomes have not improved in decades, with more than half of the patients presenting with lymph node metastases at the time of diagnosis.
J. Kühn, F. Bochen, S. Körner, B. Schick, M. Wagner, S. Smola, Barbara Berkó-Göttel, L. Morris, Jingming Wang, A. Bozzato, Maximilian Linxweiler   +10 more
semanticscholar   +1 more source

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]

, 2011
The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Abramoff, Abtahian, Alice Y. Pollitt, Aparicio-Vergara, Bertozzi, Bohmer, Brenda A. Finney, Caetano Reis e Sousa, Carramolino, Caton, Cecile Bénézech, Chagraoui, Cheng, Christou, Clausen, Colonna, Craig E. Hughes, Cueni, de Boer, Diego Mourao-Sa, Edina Schweighoffer, Francesca Barone, Gerard B. Nash, Gustafsson, Hodivala-Dilke, Hughes, Hughes, Humphreys, Ichise, Kate L. Lowe, Kaufmann, Kerrigan, Leyre Navarro-Núñez, Makinen, Martin-Villar, May, Mocsai, Mourao-Sa, Navarro, Navarro, Nicholas Smithers, Nieswandt, Pardridge, Ramirez, Saijo, Schacht, Sebzda, Spalton, Stacey A. Langan, Steve P. Watson, Steve Sheardown, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Tammela, Tang, Tiedt, Tober, Turner, Uhrin, Victor L. J. Tybulewicz, Warburton, Watson, Williams, Xie, Xu   +66 more
core   +2 more sources

Podoplanin is a negative regulator of Th17 inflammation [PDF]

JCI Insight, 2017
Recent data indicate that there are different subpopulations of Th17 cells that can express a regulatory as opposed to an inflammatory gene signature. The transmembrane glycoprotein PDPN is critical in the development of multiple organs including the lymphatic system and has been described on T cells in mouse models of autoimmune Th17 inflammation ...
Mayyan Mubarak, Vijay K. Kuchroo, Alyssa Nylander, David A. Hafler, Gerald Ponath, David Pitt, Pierre-Paul Axisa, Mary M. Tomayko   +7 more
openaire   +2 more sources

Modulation of VEGF-induced migration and network formation by lymphatic endothelial cells: Roles of platelets and podoplanin

Platelets, 2018
Lymphatic endothelial cells (LEC) express the transmembrane receptor podoplanin whose only known endogenous ligand CLEC-2 is found on platelets. Both podoplanin and CLEC-2 are required for normal lymphangiogenesis as mice lacking either protein develop a
Stacey A. Langan, Leyre Navarro-Núñez, Steve P. Watson, Gerard B. Nash   +3 more
doaj   +1 more source

Assessment of expression of podoplanin in odontogenic tumors and cysts—An immunohistochemical study

Journal of Family Medicine and Primary Care, 2020
Aim: The present study was conducted to determine the podoplanin expression in odontogenic tumors and cysts. Materials and Methods: It consisted of 12 cases of the keratocystic odontogenic tumor (KCOT), 10 cases of ameloblastoma, 8 cases of dentigerous ...
Rohit Singh, Malwika Sisodia, Ranjan Sengupta, Annu Prakash Bhindwar, Karuna Bharti, Md Abu Nafe   +5 more
doaj   +1 more source

Dye diffusion during laparoscopic tubal patency tests may suggest a lymphatic contribution to dissemination in endometriosis: A prospective, observational study [PDF]

, 2019
Aim Women with adenomyosis are at higher risk of endometriosis recurrence after surgery. This study was to assess if the lymphatic vessel network drained from the uterus to near organs where endometriosis foci lied.
Bonaccorsi, G., Greco, P., Noventa, M., Pesci, A., Scardapane, A., Scioscia, M., Zamboni, G.   +6 more
core   +1 more source