Results 41 to 50 of about 1,930 (169)
Modeling and Alanine Scanning Mutagenesis Studies of Recombinant Pokeweed Antiviral Protein [PDF]
Journal of Biological Chemistry, 2000 The Phytolacca americana-derived naturally occurring ribosome inhibitory protein pokeweed antiviral protein (PAP) is an N-glycosidase that catalytically removes a specific adenine residue from the stem loop of ribosomal RNA. We have employed molecular modeling studies using a novel model of PAP-RNA complexes and site-directed mutagenesis combined with ...
F, Rajamohan +3 more
openaire +2 more sources
Identification of a biological inactive complex form of pokeweed antiviral protein [PDF]
FEBS Letters, 1997 Pokeweed antiviral protein (PAP) inactivates both eukaryotic and prokaryotic ribosomes via a specific depurination of rRNA. The sensitivity of pokeweed ribosomes to PAP implies the existence of a mechanism to protect the plant. Using monoclonal antibodies specific to PAP, a protein complex (PAPi) which contained PAP was identified in leaf extract.
Desvoyes, Bénédicte +5 more
openaire +2 more sources
Molecular Plant-Microbe Interactions, 2005 The contamination of important agricultural products such as wheat, barley, or maize with the trichothecene mycotoxin deoxynivalenol (DON) due to infection with Fusarium species is a worldwide problem.
Rong Di, Nilgun E. Tumer
doaj +1 more source
Inhibition of herpes simplex virus multiplication by the pokeweed antiviral protein [PDF]
Antimicrobial Agents and Chemotherapy, 1980 The pokeweed antiviral protein inhibited the multiplication of herpes simplex virus type 1 in cell culture. The extent of antiviral activity was proportional to the length of time that the antiviral protein was present postinfection. The results demonstrate that the continued presence of the pokeweed antiviral protein is necessary for the maximum ...
G M, Aron, J D, Irvin
openaire +2 more sources
Case Reports in Pathology, Volume 2017, Issue 1, 2017., 2017 Non‐Hodgkin’s lymphoma (NHL) is a common malignancy of childhood; however, a lung primary presentation is an uncommon finding, as is finding an association with the Epstein‐Barr virus (EBV). We report the case of a 23‐month‐old female who developed EBV‐associated diffuse large B‐cell lymphoma (DLBCL) that was initially thought to be pneumonia ...
Eric X. Wei +4 more
wiley +1 more source
Ribosomal RNA N-glycosylase Activity Assay of Ribosome-inactivating Proteins
Bio-Protocol, 2017 Ribosome-inactivating proteins (RIPs) are enzymes that irreversibly inactivate ribosomes as a consequence of their N-glycosylase (EC 3.2.2.22) activity. The enzyme cleaves the N-glycosidic bond between the adenine No.
José Ferreras +2 more
doaj +1 more source
Immunomodulation and Anti‐Inflammatory Effects of Garlic Compounds
Journal of Immunology Research, Volume 2015, Issue 1, 2015., 2015 The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield different preparations with differences
Rodrigo Arreola +7 more
wiley +1 more source
Journal of Viruses, Volume 2014, Issue 1, 2014., 2014 This paper highlights various reasons of evolution of new mutants/variants of JE virus and its effects on neurovirulence, antigenicity, host immune responses, and disease transmission in endemic areas. Virus is reorganizing its genome by making sequence alterations, single site mutations, cluster specific reversions, and amino acid substitutions in ...
Ravi Kant Upadhyay, Piet Maes
wiley +1 more source
Testing of disease-resistance of pokeweed antiviral protein gene (PacPAP) in transgenic cucumber (Cucumis sativus) [PDF]
, 2013 Transformation of pokeweed antiviral protein gene (PAP) into plants was shown to improve plant resistance to several viruses or fungi pathogens with no much negative effect on plant growth.
Cao, B +6 more
core +2 more sources
An Update in the Use of Antibodies to Treat Glioblastoma Multiforme
Autoimmune Diseases, Volume 2013, Issue 1, 2013., 2013 Glioblastoma is a deadly brain disease and modest improvement in survival has been made. At initial diagnosis, treatment consists of maximum safe surgical resection, followed by temozolomide and chemoirradiation or adjuvant temozolomide alone. However, these treatments do not improve the prognosis and survival of patients.
Norma Y. Hernández-Pedro +5 more
wiley +1 more source