Results 31 to 40 of about 766,224 (285)

Microtubules originate asymmetrically at the somatic golgi and are guided via Kinesin2 to maintain polarity within neurons

eLife, 2020
Neurons contain polarised microtubule arrays essential for neuronal function. How microtubule nucleation and polarity are regulated within neurons remains unclear.
Amrita Mukherjee, Paul S Brooks, Fred Bernard, Antoine Guichet, Paul T Conduit   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Changes of cytoskeleton and polarity in cardiomyocyte-like cells derived from left ventricular noncompaction patients

Di-san junyi daxue xuebao, 2021
Objective To investigate the changes and mechanism of the cytoskeleton and polarity in cardiomyocyte-like cells derived from patients with left ventricular noncompaction (LVNC). Methods After induced pluripotent stem cells (iPSCs) were isolated from LVNC
GUO Yun, GE Mei, LIU Aoyi, LYU Tiewei
doaj   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Automatically extracting polarity-bearing topics for cross-domain sentiment classification [PDF]

, 2011
Joint sentiment-topic (JST) model was previously proposed to detect sentiment and topic simultaneously from text. The only supervision required by JST model learning is domain-independent polarity word priors.
Alani, Harith, He, Yulan, Lin, Chenghua
core   +1 more source

Stochastic model for cell polarity

, 2012
Cell polarity refers to the spatial asymmetry of molecules on the cell membrane. Altschuler, Angenent, Wang and Wu have proposed a stochastic model for studying the emergence of polarity in the presence of feedback between molecules.
Gupta, Ankit
core   +1 more source

Memristive excitable cellular automata [PDF]

, 2011
The memristor is a device whose resistance changes depending on the polarity and magnitude of a voltage applied to the device's terminals. We design a minimalistic model of a regular network of memristors using structurally-dynamic cellular automata ...
Adamatzky A., ANDREW ADAMATZKY, Halpern P., Ilachinsky A., LEON CHUA, Williams R. S.   +5 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration

eLife, 2019
Non-canonical Wnt signaling plays a central role for coordinated cell polarization and directed migration in metazoan development. While spatiotemporally restricted activation of non-canonical Wnt-signaling drives cell polarization in epithelial tissues,
Daniel Čapek, Michael Smutny, Alexandra-Madelaine Tichy, Maurizio Morri, Harald Janovjak, Carl-Philipp Heisenberg   +5 more
doaj   +1 more source

Dipole Moment‐ and Molecular Orbital‐Engineered Phosphine Oxide‐Free Host Materials for Efficient and Stable Blue Thermally Activated Delayed Fluorescence

Advanced Science, 2022
To utilize thermally activated delayed fluorescence (TADF) technology for future displays, it is necessary to develop host materials which harness the full potential of blue TADF emitters. However, no publication has reported such hosts yet. Although the
Soo‐Ghang Ihn, Daun Jeong, Eun Suk Kwon, Sangmo Kim, Yeon Sook Chung, Myungsun Sim, Jun Chwae, Yasushi Koishikawa, Soon Ok Jeon, Jong Soo Kim, Joonghyuk Kim, Sungho Nam, Inkoo Kim, Sangho Park, Dae Sin Kim, Hyeonho Choi, Sunghan Kim   +16 more
doaj   +1 more source