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Implementation of Poliovirus Containment in Poliovirus Designated Facilities—United States, 2017–2024 [PDF]

Pathogens
As the world approaches wild poliovirus eradication, effective containment measures are essential to minimize the risk of a facility-associated reintroduction into a polio-free community.
Christy Ottendorfer, Patrick Vander Kelen, Cecelia A. Sanders, Emily Watson, Suganthi Suppiah, William Hoffman, Colby Sinclair, Abena Marfo, Lia Haynes Smith   +8 more
doaj   +2 more sources

Evaluation of hyper-attenuated S19 poliovirus strains for use in poliovirus neutralization assays. [PDF]

PLoS ONE
Poliovirus eradication efforts have relied on effective vaccination campaigns and stringent laboratory containment of poliovirus strains. Serological testing is the primary means to address population immunity, vaccine efficacy, and individual poliovirus
Nicholas Wiese, William Hendley, Basit Jafri, Kathryn A V Jones, Giovanna Sifontes, Sandra Valdez, Yiting Zhang, Bernardo A Mainou   +7 more
doaj   +2 more sources

Surveillance of Acute Flaccid Paralysis (AFP) in Greece: 2008–2024 [PDF]

Pathogens
As part of the WHO’s Global Polio Eradication Initiative, acute flaccid paralysis (AFP) surveillance in children under 15 years old is crucial for monitoring the emergence of polioviruses and tracking Non-Polio Enteroviruses (NPEVs).
Stavroula Labropoulou, Theano Georgakopoulou, Vahid Baniasadi, Giota Mpizta, Stella Vorre, Maria Theodoridou, Mary Emmanouil, Emmanouil Angelakis   +7 more
doaj   +2 more sources

Neutralizing human monoclonal antibodies to poliovirus map to the receptor binding site [PDF]

Nature Communications
Poliovirus remains a serious threat to human health. Complete eradication of wild-type poliovirus has not yet succeeded, making the development of successful antivirals critical.
Benjamin T. Waddey, Andrew J. Charnesky, Julia E. Faust, Nadia M. DiNunno, Rama Devudu Puligedda, Sung Hyun Cho, Carol M. Bator, Steven D. Dong, Kutub Mahmood, Konstantin M. Chumakov, Scott K. Dessain, Susan L. Hafenstein   +11 more
doaj   +2 more sources

Direct detection of polioviruses using a recombinant poliovirus receptor.

PLoS ONE, 2021
Polioviruses are positive-sense, single-stranded RNA picornaviruses and the principal cause of poliomyelitis. Global poliovirus surveillance has relied on poliovirus isolation in cells, which may take a minimum of 10 days, involves maintaining two cell ...
Nancy Gerloff, Mark Mandelbaum, Hong Pang, Nikail Collins, Brittani Brown, Hong Sun, Chelsea Harrington, Jessica Hecker, Chadi Agha, Cara C Burns, Everardo Vega   +10 more
doaj   +2 more sources

Interaction of the poliovirus receptor with poliovirus [PDF]

Proceedings of the National Academy of Sciences, 2000
The structure of the extracellular, three-domain poliovirus receptor (CD155) complexed with poliovirus (serotype 1) has been determined to 22-Å resolution by means of cryo-electron microscopy and three-dimensional image-reconstruction techniques. Density corresponding to the receptor was isolated in a difference electron density map and fitted with ...
He, Yongning, Bowman, Valorie D., Mueller, Steffen, Bator, Carol M., Bella, Jordi, Peng, Xiaozhong, Baker, Timothy S., Wimmer, Eckard, Kuhn, Richard J., Rossmann, Michael G.   +9 more
openaire   +3 more sources

Does IPV Boost Intestinal Immunity among Children under Five Years of Age? An Experience from Pakistan

Vaccines, 2023
The oral poliovirus vaccine (OPV) has been the mainstay of polio eradication, especially in low-income countries, and its use has eliminated wild poliovirus type 2.
Muhammad Atif Habib, Sajid Bashir Soofi, Imtiaz Hussain, Imran Ahmed, Zamir Hussain, Rehman Tahir, Saeed Anwar, Simon Cousens, Zulfiqar A. Bhutta   +8 more
doaj   +1 more source

THERMOSENSITIVITY OF POLIOVIRUS [PDF]

Journal of Bacteriology, 1963
Wallis, Craig(Baylor University College of Medicine, Houston, Tex.)and Joseph L. Melnick. Thermosensitivity of poliovirus. J. Bacteriol.86:499–504. 1963.—Polioviruses are thermosensitive agents, although thermoresistant strains have been obtained and reported in the literature. Such resistant strains can be developed by exposure of the virus to cystine
C, WALLIS, J L, MELNICK
openaire   +2 more sources

Risk Assessment and Virological Monitoring Following an Accidental Exposure to Concentrated Sabin Poliovirus Type 3 in France, November 2018

Vaccines, 2020
The safe and secure containment of infectious poliovirus (PV) in facilities where live PV are handled is the condition to achieve and maintain poliomyelitis eradication.
Marion Jeannoël, Denise Antona, Clément Lazarus, Bruno Lina, Isabelle Schuffenecker   +4 more
doaj   +1 more source

Poliovirus [PDF]

Pediatrics, 2011
This Policy Statement was retired January 2015. Despite marked progress in global polio eradication, the threat of polio importation into the United States remains; therefore, all children should be protected against the disease. The standard schedule for poliovirus immunization remains 4 doses of inactivated poliovirus vaccine at 2, 4 ...
openaire   +2 more sources