Results 11 to 20 of about 41,706 (206)

A Pseudovirus-Based Method for the Simultaneous Quantitation of Neutralization Antibodies Against All Three Poliovirus Serotypes. [PDF]

MedComm (2020)
By optimizing P1 expression, sensitive cell selection, and plasmid transfection ratios, we produced a high‐titer poliovirus pseudovirus. Based on high‐titer pseudovirus encoding distinct fluorophores (E2, eGFP, and RFP), we developed a tri‐color pseudovirus‐based neutralization assay (PBNA) for the simultaneous quantification of neutralizing antibodies
Liu M, Yu Y, Li Y, Tao Z, Huang L, Wu X, Zhang Y, Zhu S, Sun Q, Ji T, Wang D, Liang Z, Liu S, Cai M, An Y, Li J, Huang W, Liao G, Yi L, Ma L, Zhang L, Wang Y.   +21 more
europepmc   +2 more sources

The effect of maternal poliovirus antibodies on the immune responses of infants to poliovirus vaccines

BMC Infectious Diseases, 2020
Background Maternal poliovirus antibodies could provide passive immunity to the newborns from poliovirus infection during their first few months of life, but they may impair the immune responses of infants to the poliovirus vaccine as well. In our study,
Siyue Jia, Rong Tang, Guifan Li, Yuemei Hu, Qi Liang   +4 more
doaj   +1 more source

Poliovirus biology [PDF]

Structure, 1996
Poliomyelitis has been largely controlled by the use of attenuated live vaccine strains. The molecular basis of attenuation is beginning to be understood, but the interactions between the virus and its human host remain mysterious.
openaire   +2 more sources

Update on Pakistan Polio Eradication Initiative

Journal of Shalamar Medical & Dental College, 2022
The global polio eradication initiative (GPEI) was established in 1988 as a result of the declaration of commitment by the World Health Assembly. In Pakistan, National Emergency Action Plan [NEAP] coined the strategies under government directives to ...
Maryam Riaz Tarar
doaj   +1 more source

Effects of maternal antibodies in infants on the immunogenicity and safety of inactivated polio vaccine in infants

Human Vaccines & Immunotherapeutics, 2022
The presence of maternal poliovirus antibodies may interfere with the immune response to inactivated polio vaccine (IPV), and its influence on the safety of vaccination is not yet understood.
Shuyu Gao, Mingwei Wei, Kai Chu, Jingxin Li, Fengcai Zhu   +4 more
doaj   +1 more source

Multiplex PCR-Based Neutralization (MPBN) Assay for Titers Determination of the Three Types of Anti-Poliovirus Neutralizing-Antibodies

Vaccines, 2020
Determination of poliovirus-neutralizing antibodies is an important part of clinical studies of poliovirus vaccines, epidemiological surveillance and seroprevalence studies that are crucial for global polio eradication campaigns.
Hasmik Manukyan, Svetlana Petrovskaya, Konstantin Chumakov, Majid Laassri   +3 more
doaj   +1 more source

Emergence of vaccine-derived poliovirus type 2 after using monovalent type 2 oral poliovirus vaccine in an outbreak response, Philippines

Western Pacific Surveillance and Response, 2022
Objective: In response to an outbreak of circulating vaccine-derived poliovirus (cVDPV) type 2 in the Philippines in 2019–2020, several rounds of supplementary immunization activities using the monovalent type 2 oral poliovirus vaccine (OPV) were ...
SweetC B Alipon, Yoshihiro Takashima, Tigran Avagyan, Varja Grabovac, Syeda Kanwal Aslam, Benjamin Bayutas, Josephine Logronio, Xiaojun Wang, Achyut Shrestha, Sukadeo Neupane, Maria Concepcion Roces, Lea Necitas Apostol, Nemia Sucaldito   +12 more
doaj   +1 more source

Poliovirus immunity among adults in the Democratic Republic of the Congo: a cross-sectional serosurvey

BMC Infectious Diseases, 2022
Background Vaccination efforts to eradicate polio currently focus on children under 5 years of age, among whom most cases of poliomyelitis still occur. However, in the Democratic Republic of the Congo (DRC), an outbreak of wild poliovirus type 1 occurred
Vivian H. Alfonso, Arie Voorman, Nicole A. Hoff, William C. Weldon, Sue Gerber, Adva Gadoth, Megan Halbrook, Amelia Goldsmith, Patrick Mukadi, Reena H. Doshi, Guillaume Ngoie-Mwamba, Trevon L. Fuller, Emile Okitolonda-Wemakoy, Jean-Jacques Muyembe-Tamfum, Anne W. Rimoin   +14 more
doaj   +1 more source

PREVALENCE OF NEUTRALIZING ANTIBODIES AGAINST POLIOVIRUS 1, 2, AND 3 IN HEALTHCARE PROFESSIONALS AGED 20-50 YEARS

Revista Paulista de Pediatria, 2021
Objective: To describe the prevalence of neutralizing antibodies against poliovirus (PV1, PV2, and PV3) in blood samples of healthcare professionals aged 20 to 50 years.
José Cassio de Moraes, Maria Josefa Penon Rujula, Marcelo Otsuka   +2 more
doaj   +2 more sources

First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus

International Journal of Infectious Diseases, 2019
This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut.
Merav Weil, Galia Rahav, Raz Somech, Tali Stauber, Jacqueline Alfandari, Leah Weiss, Ilana Silberstein, Victoria Indenbaum, Itay Bar Or, Ella Mendelson, Danit Sofer, Lester M. Shulman   +11 more
doaj   +1 more source