Results 61 to 70 of about 7,804 (207)

Breast Cancer: Molecular Pathogenesis, Targeted Therapy, Screening, and Prevention

MedComm, Volume 7, Issue 1, January 2026.
The review manuscript examines the molecular pathogenesis, screening, prevention advances, and evolving targeted therapies in breast cancer. It highlights the integration of AI and multiomics for precision prevention and personalized treatment, pointing toward future directions in equitable cancer care.
Huijun Lei, Jinzhen Fu, Wei Gu, Hongjin Qiao, Huixue Guo, Zijian Chen, San Ming Wang, Tianhui Chen   +7 more
wiley   +1 more source

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, Volume 2, Issue 1, Page 61-93, January 2026.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

Circulating Vaccine Derived Poliovirus and the polio eradication endgame

, 2013
No Abstract. Key words: Polio, polio eradication, vaccine derived poliovirus, Oral polio vaccine, inactivated polio vaccine ...
Wright, PF, Davis, R
core   +1 more source

Environmental Surveillance of Polioviruses in Armenia, Colombia before Trivalent Oral Polio Vaccine Cessation

Viruses, 2019
Although acute flaccid paralysis (AFP) surveillance is the “gold standard” for detecting cases of polio, environmental surveillance can provide supplementary information in the absence of paralytic poliomyelitis cases.
María Mercedes González, Magile C. Fonseca, Carlos Andrés Rodríguez, Alejandra María Giraldo, José Joaquín Vila, Jhon Carlos Castaño, Leonardo Padilla, Luis Sarmiento   +7 more
doaj   +1 more source

Sodium Copper Chlorophyllin Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection Through Multiple Antiviral Mechanisms

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to the global swine industry due to its extensive genetic diversity and limited vaccine cross‐protection. Antiviral strategies that target both viral infection and host pathological responses are urgently needed.
Xinrong Wang, Juan Zhang, Li Rui, Junhai Zhu, Nan Yan, Meiyu Jia, Longxiang Zhang, Lizhi Fu, Yue Wang, Jianchao Wei   +9 more
wiley   +1 more source

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Systematic Review of Postvaccination Ocular Adverse Events: A Comprehensive Analysis of Published Reports

Journal of Medical Virology, Volume 97, Issue 12, December 2025.
ABSTRACT Ocular adverse events following COVID‐19 vaccination are well described; however, systematic analyses of non‐COVID antiviral vaccines remain limited. This review aimed to evaluate ocular complications associated with non‐COVID antiviral immunizations, including influenza, varicella‐zoster (VZV), human papillomavirus (HPV), and hepatitis B (HBV)
Yaru Zou, Koju Kamoi, Yuan Zong, Jing Zhang, Mingming Yang, Kyoko Ohno‐Matsui   +5 more
wiley   +1 more source

A Pseudovirus‐Based Method for the Simultaneous Quantitation of Neutralization Antibodies Against All Three Poliovirus Serotypes

MedComm, Volume 6, Issue 12, December 2025.
By optimizing P1 expression, sensitive cell selection, and plasmid transfection ratios, we produced a high‐titer poliovirus pseudovirus. Based on high‐titer pseudovirus encoding distinct fluorophores (E2, eGFP, and RFP), we developed a tri‐color pseudovirus‐based neutralization assay (PBNA) for the simultaneous quantification of neutralizing antibodies
Meiyan Liu, Yuanling Yu, Yadong Li, Zexin Tao, Lan Huang, Xi Wu, Yong Zhang, Shuangli Zhu, Qiang Sun, Tianjiao Ji, Dongyan Wang, Ziteng Liang, Shuo Liu, Meina Cai, Yimeng An, Jierui Li, Weijin Huang, Guoyang Liao, Li Yi, Lei Ma, Li Zhang, Youchun Wang   +21 more
wiley   +1 more source

Crosstalk Between Cancer‐Associated Fibroblasts and Immune Cells: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Cancer‐associated fibroblasts (CAFs) are widely engaged in tumor progression in the tumor microenvironment. CAFs interact actively with immunocytes including tumor‐associated macrophages, T cells, neutrophils, and NK cells in a positive‐feedback loop to sculpt tumor immune microenvironment and participate in tumor activities and antitumor therapy ...
Ya Li, Xingpeng Di, Jiawei Chen, Jingwen Wei, Tianyue Li, Kunjie Wang, Banghua Liao, Deyi Luo   +7 more
wiley   +1 more source

Vaccine-associated paralytic poliomyelitis in Russian Federation during the period of changes in vaccination schedule (2006-2013 y.y.)

Вопросы вирусологии, 2016
The results of virologic testing of clinical materials and epidemiological analysis of vaccine-associated paralytic poliomyelitis (VAPP) cases obtained in 2006-2013 during AFP surveillance are presented. Among the 2976 cases of AFP 30 cases were vapp. 15
O. E. Ivanova, T. P. Eremeeva, N. S. Morozova, A. K. Shakaryan, A. P. Gmyl, M. L. Yakovenko, E. A. Korotkova, O. P. Chernjavskaja, O. Yu. Baykova, O. V. Silenova, A. Yu. Krasota, L. I. Krasnoproshina, A. N. Mustafina, L. I. Kozlovskaja   +13 more
doaj   +1 more source