Results 41 to 50 of about 385,811 (204)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Purification and concentration of model viruses using single‐pass tangential flow filtration

Biotechnology Progress, EarlyView.
Single‐pass TFF was developed for an enveloped and non‐enveloped virus for use in continuous downstream purification processes. Enveloped virus was concentrated and purified. Abstract The vaccine and viral vector industry is growing at an accelerated rate.
Luis Alberto Mejía‐Manzano, Lynn Manchester, Grace Wallis, Kan Wang, Bruce P. Lee, Michael Betenbaugh, Caryn L. Heldt   +6 more
wiley   +1 more source

Formaldehyde-inactivated human enterovirus 71 vaccine is compatible for co-immunization with a commercial pentavalent vaccine

, 2011
[[abstract]]In this study we tested the effectiveness of a formaldehyde-inactivated EV71 vaccine and its compatibility for co-immunization with a pentavalent vaccine that contained inactivated poliovirus (PV) vaccine.
Chen, CW;Lee, YP;Wang, YF;Yu, CK
core   +1 more source

Circulating Vaccine Derived Poliovirus and the polio eradication endgame [PDF]

, 2013
No Abstract. Key words: Polio, polio eradication, vaccine derived poliovirus, Oral polio vaccine, inactivated polio vaccine ...
Wright, PF, Davis, R
core   +1 more source

Detection of vaccine-derived poliovirus type-3 in sewage of Kathmandu Valley, Nepal

Clinical Infection in Practice
Enteroviruses include polioviruses, which are classified into three types: type 1, type 2, and type 3. The oral polio vaccine (OPV), which contains attenuated strains of these three types, has been pivotal in reducing polio incidence worldwide.
Rachana Mehta, Amrendra Kushwaha, Sanjit Sah, Jack Feehan, Vasso Apostolopoulos   +4 more
doaj   +1 more source

Ascertainment of childhood vaccination histories in northern Malawi.

, 2008
OBJECTIVE: To assess factors related to recorded vaccine uptake, which may confound the evaluation of vaccine impact. METHODS: Analysis of documented vaccination histories of children under 5 years and demographic and socio-economic characteristics ...
Mwinuka, V, Mwagomba, D., Crampin, A.C., McGrath, N, J. Mwafilaso, A. Jahn, Karsulukuta, A., Khunga, A, P. E. M. Fine, Mkisi, RE, Branson, K, A. Katsulukuta, Floyd, S., A. C. Crampin, K. Branson, V. Mwinuka, Branson, K., Fine, P.E.M., Mwafilaso, J., McGrath, N., D. Mwagomba, Khunga, A., S. Floyd, Katsulukuta, A, A. Khunga, Mwafilaso, J, N. McGrath, Jahn, A, Jahn, A., Mwinuka, V., R. E. Mkisi, Crampin, AC, Mwagomba, D, Mkisi, R.E., Katsulukuta, A., Fine, PEM, Floyd, S   +36 more
core   +1 more source

A Randomized Phase 4 Study of Immunogenicity and Safety After Monovalent Oral Type 2 Sabin Poliovirus Vaccine Challenge in Children Vaccinated with Inactivated Poliovirus Vaccine in Lithuania. [PDF]

, 2021
BACKGROUND: Understanding immunogenicity and safety of monovalent type 2 oral poliovirus vaccine (mOPV2) in inactivated poliovirus vaccine (IPV)-immunized children is of major importance in informing global policy to control circulating vaccine-derived ...
Usonis, Vytautas,, Ackerman, Margaret E.,, Wright, Peter, Oberste, M. Steven,, Usonis, Vytautas, Rüttimann, Ricardo,, Connor, Ruth I.,, Bandyopadhyay, Ananda S.,, Wright, Peter,, Rüttimann, Ricardo, Wieland-Alter, Wendy F.,, Gast, Chris,, Connor, Ruth I, Oberste, M Steven, Weldon, William C, Weldon, William C.,, Clemens, Ralf,, Bandyopadhyay, Ananda S, Brickley, Elizabeth B, Wieland-Alter, Wendy F, Gast, Chris, Clemens, Ralf, Ackerman, Margaret E, Brickley, Elizabeth B.,   +23 more
core   +2 more sources

Immunogenicity of Catch-Up Immunization with Conventional Inactivated Polio Vaccine among Japanese Adults

Vaccines, 2022
Most Japanese adults are vaccinated twice with the Sabin trivalent oral polio vaccine. Booster vaccination is recommended for Japanese travelers to polio-endemic/high-risk countries.
Shinji Fukushima, Takashi Nakano, Hiroyuki Shimizu, Atsuo Hamada   +3 more
doaj   +1 more source

A Global Perspective of Childhood Vaccinations: Past, Present, and Future—From Smallpox to mRNA

Acta Paediatrica, EarlyView.
ABSTRACT Childhood immunisation is one of the most successful public health interventions in history, preventing millions of deaths and substantially reducing global child mortality. This mini‐review summarises the historical development of childhood vaccines, the role of global coordination in expanding immunisation coverage, and the innovations that ...
Tobias Alfvén, Tania Reza, Alieu Sowe
wiley   +1 more source

The role of a genetically stable, novel oral type 2 poliovirus vaccine in the poliomyelitis endgame

Revista Panamericana de Salud Pública, 2023
Poliovirus infection causes paralysis in up to 1 in 200 infected persons. The use of safe and effective inactivated poliovirus vaccines and live attenuated oral poliovirus vaccines (OPVs) means that only two pockets of wildtype poliovirus type 1 remain ...
Sue Ann Costa Clemens, Gustavo Mendes Lima Santos, Isabela Gonzalez, Ralf Clemens   +3 more
doaj   +1 more source