Results 81 to 90 of about 11,399 (257)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Telemedicine – How Does it Work in Practice?

, 2017
IntroductionToday telemedicine is a very popular and rapidly growing area, which allows the treatment, regardless of the distance between the patient and doctor.
J. Wutke, M. Wojtuszek, J. Kachnic, M. Krzystanek, K. Krysta   +4 more
core   +1 more source

Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project

Frontiers in Physics, 2020
Particle therapy is a growing cancer treatment modality worldwide. However, there still remains a number of unanswered questions considering differences in the biological response between particles and photons.
Nicholas T. Henthorn, Nicholas T. Henthorn, Olga Sokol, Marco Durante, Marco Durante, Ludovic De Marzi, Frederic Pouzoulet, Justyna Miszczyk, Pawel Olko, Sytze Brandenburg, Sytze Brandenburg, Marc Jan van Goethem, Marc Jan van Goethem, Lara Barazzuol, Lara Barazzuol, Makbule Tambas, Johannes A. Langendijk, Marie Davídková, Vladimír Vondráĉek, Elisabeth Bodenstein, Joerg Pawelke, Joerg Pawelke, Antony J. Lomax, Antony J. Lomax, Damien C. Weber, Damien C. Weber, Damien C. Weber, Alexandru Dasu, Alexandru Dasu, Bo Stenerlöw, Per R. Poulsen, Brita S. Sørensen, Cai Grau, Mateusz K. Sitarz, Anne-Catherine Heuskin, Stephane Lucas, John W. Warmenhoven, John W. Warmenhoven, Michael J. Merchant, Michael J. Merchant, Ran I. Mackay, Ran I. Mackay, Karen J. Kirkby, Karen J. Kirkby   +43 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology [PDF]

, 2019
Compound screening in biological assays and subsequent optimization of hits is indispensable for the development of new molecular research tools and drug candidates.
Stechmann, B., Nam, Faranak, Brea, J. (Jose), Pilarski, R. (Radoslaw), Vicente, Francisca, Jirgenson, Aigars, Krauss, Stefan, Genilloud, Olga, Quintana, J. (Jordi), Brennecke, P., Mestres, Jordi, Aubi Catevilla, Oscar, Neuenschwander, Martin, Landskron, Johannes, Rasina, D., Neuenschwander, M., Rasina, Dace, von Kries, Jens P., Brennecke, P. (Philip), Cautain, B., Vicente, F., Tásken, Kjetil, Cautain, B. (Bastien), Stechmann, B. (Bahne), Kolanowski, J. (Jacek), Lickert, H. (Heiko), von Kries, Jens, Martinez, A., Mestres, J., Simova, S., Aubi, O., Genilloud, O. (Olga), Lickert, Heiko, Fecke, W., Leśnikowski, Z. (Zbigniew), Herzog, K., Nami, F. (Faranak), Bilitewski, U. (Ursula), Quintana, J., Hansen, E. (Espen), von Kries, J.P., Leśnikowski, Z., Andersen, J. (Jeanette), Laraia, Luca, Bilitewski, Ursula, Specker, E., Vicent, Maria J., Bartunek, P. (Petr), Kolanowski, J.L., Aubi, O. (Oscar), Simova, S. (Sarka), Pilarski, Radoslaw, Nami, Faranak, Herzog, K. (Katja), Specker, E. (Edgar), Vicent, M.J., Genilloud, O., Quintana, Jordi, Specker, Edgar, Martinez, Aurora, Zielenkiewicz, P. (Piotr), Vicent, M. (Maria), Fecke, Wolfgang, von Kries, J. (Jens), Cautain, Bastien, Hansen, E., Pineda-Lucena, A., Brea, Jose, Pilarski, Radosław, Kolanowski, Jacek L, Clausen, M. (Mads), Clausen, Mads H, Martinez, A. (Aurora), Aubi, Oscar, Brennecke, Philip, Nazaré, Marc, Pineda-Lucena, Antonio, Nazaré, M. (Marc), Paruch, Kamil, Orzaez, M. (Mar), Broenstrup, Mark, Gribbon, P. (Philip), Lëhtio, Lari, Laraia, L., Rasina, D. (Dace), Ellinger, Bernhard, Krauss, S. (Stefan), Pilarsk, Radosław, Herzog, Katja, Hansen, Espen, Nazaré, M., Paruch, K., Brönstrup, M., Lickert, H., Clausen, Mads H., Clausen, Mads Hartvig, Neuenschwander, M. (Martin), Taskén, K. (Kjetil), Pineda-Lucena, A. (Antonio), Laraia, L. (Luca), Gribbon, P., Orzaez, Mar, Bartunek, Petr, Andersen, Jeanette, Orzaez, M., Bilitewski, U., Kries, Jens P. von, Paruch, K. (Kamil), Clausen, Mads, Brönstrup, M. (Mark), Kolanowski, Jacek, Ellinger, B., Lehtiö, L., Lesinikowski, Zbigniew, Andersen, Jeanette H, Vicent, Maria J, Andersen, Jeanette hammer, Jirgenson, A. (Aigars), Pienda-Lucena, Antonio, Vicent, Maria, Lehtiö, L. (Lari), Vicente, F. (Francisca), Zielenkiewicz, Piotr, Simova, Sarka, Andersen, J.H., Brea Floriani, José Manuel, Pilarski, R., Landskron, J. (Johannes), Mestres, J. (Jordi), Gribbon, Philip, Bartunek, P., Zielenkiewicz, P., Krauss, S., Taskén, K., Stechmann, Bahne, Clausen, M.H., Brönstrup, Mark, Jirgensons, A., Kolanowski, Jacek L., Andersen, Jeanette H., Ellinger, B. (Bernhard), Leśnikowski, Zbigniew, Jirgensons, Aigars, Lanskron, Johannes, Brea, J., Fecke, W. (Wolfgang), von Kries, Jens P, Landskron, J., Nami, F.   +148 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Effect of alteplase on the CT hyperdense artery sign and outcome after ischemic stroke [PDF]

, 2015
© 2015 American Academy of Neurology. STUDY FUNDING The startup phase of IST-3 was supported by a grant from the Stroke Association, UK (TSA 04/99). The expansion phase was funded by the Health Foundation UK (2268/1282).
Sandercock, Peter, Whiteley, William N; id_orcid, Farrall, Andrew, Sandercock, Peter A G, IST 3 Collaborative Group, von Heijne, A., Potter, Gillian, Sandercock, Peter A. G, BALESTRINO, MAURIZIO, Mair, Grant, Cala, Lesley, Adami, Alessandro, Lindley, Richard I, Morris, Zoe, Bradey, N., Cohen, Geoff, Peeters, André, Sandercock, Peter A. G., Lindley, Richard I., Emsley, Hedley, von Kummer, Ruediger, Lundström, Erik,, Bradey, Nick, von Kummer, Rüdiger, as a. group member, Wardlaw, Joanna M, von Heijne, Anders, ?, ?, Farrall, Andrew J, Lindley, Richard, Farrall, Andrew J., TAMBURIN, Stefano, IST-3 Collaborative Group, Wardlaw, Joanna M., Sandercock, Peter AG, Wardlaw, Joanna   +35 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Safety and biodistribution of intrathecal administration of mesenchymal stem cells (MSCs) and neurotrophin-releasing nanoparticles in a porcine CSF-guided delivery model for amyotrophic lateral sclerosis (ALS) drug discovery

Scientific Reports
Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disorder that complicates the identification of effective therapeutic targets. The potential of stem cells and neurotrophins as promising candidates has become increasingly evident,
Emilia Sinderewicz, Maria Dąbkowska, Anna Sarnowska, Joanna Staszkiewicz-Chodor, Dorota Mystkowska, Piotr Holak, Igor Drozd, Magdalena Chodkowska-Michalowska, Monika Rytel, Edyta Paczkowska, Marcin P. Mycko, Boguslaw Machalinski, Katarzyna Jezierska-Wozniak   +12 more
doaj   +1 more source