Results 31 to 40 of about 15,983 (179)
Nature Communications, 2017 Drosophila Polo kinase is the founding member of the Polo-Like Kinase (PLK) family and a master regulator of mitosis and cytokinesis. Here the authors uncover a molecular mechanism for the spatiotemporal regulation of Polo kinase during mitotic entry ...
David Kachaner +5 more
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Journal of Analytical Science and Technology, 2022 Lung cancer is the second most commonly reported type of cancer worldwide. Approximately 80–85% of lung cancer occurrences are accounted by non-small cell lung cancer (NSCLC).
Pethaiah Gunasekaran +11 more
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Targeting Polo-like Kinase in Cancer Therapy [PDF]
Clinical Cancer Research, 2010 Abstract Polo-like kinases (Plk) function in mitosis and maintaining DNA integrity. There are four family members, of which Plk1 represents a target for anticancer therapy. Plk1 is only expressed in dividing cells with peak expression during G2/M.
Yan, Degenhardt, Thomas, Lampkin
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Divergent polo box domains underpin the unique kinetoplastid kinetochore [PDF]
Open Biology, 2016 Kinetochores are macromolecular machines that drive eukaryotic chromosome segregation by interacting with centromeric DNA and spindle microtubules. While most eukaryotes possess conventional kinetochore proteins, evolutionarily distant kinetoplastid ...
Olga O. Nerusheva, Bungo Akiyoshi
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Haematologica, 2017 Nearly one-third of patients with acute myeloid leukemia have FMS-like tyrosine kinase 3 mutations and thus have poor survival prospects. Receptor tyrosine kinase anexelekto is critical for FMS-like tyrosine kinase 3 signaling and participates in FMS ...
Peter P. Ruvolo +11 more
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Acta Pharmaceutica Sinica B, 2019 Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity.
Sara Abdelfatah +10 more
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Polo-like Kinase 4 Shapes Up [PDF]
Structure, 2014 Polo-like kinase 4 (Plk4) is a master regulator of centriole duplication and targets to centrioles through the association of its cryptic polo box domain with centriole receptors. In this issue of Structure, Shimanovskaya and colleagues unveil a new dimeric architecture of Plk4's cryptic polo box that reveals a conserved mechanism for centriole ...
Levine, Michelle S., Holland, Andrew J.
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Xenopus Polo-like kinase Plx1: a multifunctional mitotic kinase [PDF]
Oncogene, 2005 The Xenopus Polo-like kinase Plx1 plays multiple roles in mitosis. Accumulating evidence shows that Plx1 is the trigger kinase for the G2/M transition that phosphorylates and activates the phosphatase Cdc25C, which subsequently dephosphorylates Cdc2/cyclin B and initiates a positive feedback loop between Cdc25C and Cdc2/cyclin B.
Junjun, Liu, James L, Maller
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PLoS ONE, 2011 The polo-like kinase in the deep branching eukaryote Trypanosoma brucei (TbPlk) has many unique features. Unlike all the other polo-like kinases known to associate with the nucleus and controlling both mitosis and cytokinesis, TbPlk localizes to the ...
Lu Sun, Ching C Wang
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Identification of polo‐like kinase 1 as a therapeutic target in murine lupus
Clinical & Translational Immunology, 2022 Introduction The signalling cascades that contribute to lupus pathogenesis are incompletely understood. We address this by using an unbiased activity‐based kinome screen of murine lupus.
Yaxi Li +6 more
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