Results 11 to 20 of about 5,163,498 (211)
Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells [PDF]
Haematologica, 2013 This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia.
Stefanie A. Hartsink-Segers +8 more
doaj +2 more sources
Polo-like Kinase 4 Shapes Up [PDF]
Structure, 2014 Polo-like kinase 4 (Plk4) is a master regulator of centriole duplication and targets to centrioles through the association of its cryptic polo box domain with centriole receptors. In this issue of Structure, Shimanovskaya and colleagues unveil a new dimeric architecture of Plk4's cryptic polo box that reveals a conserved mechanism for centriole ...
Levine, Michelle S., Holland, Andrew J.
openaire +4 more sources
The balance of Polo-like kinase 1 in tumorigenesis [PDF]
Cell Division, 2009 Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role to ensure the normal mitosis. Interestingly,
Yu Xiaochun, Lu Lin-Yu
doaj +4 more sources
Polo like kinase 2 tumour suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer [PDF]
, 2012 The polo-like kinase PLK2 has recently been identified as a potential theranostic marker in the management of chemotherapy sensitive cancers. The methylation status of the PLK2 CpG island varies with sensitivity to paclitaxel and platinum in ovarian ...
Mcneish, I. +6 more
core +8 more sources
Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)
Bioinformatics and Biology Insights, 2012 Computational design of small molecule putative inhibitors of Polo-like kinase 1 (Plk1) is presented. Plk1, which regulates the cell cycle, is often over expressed in cancers. Down regulation of Plk1 has been shown to inhibit tumor progression.
Krupa S. Jani, D.S. Dalafave
doaj +3 more sources
Current Biology, 2013 What is Polo and what are Plks? Plk stands for Polo-like kinase. In the 1980s, genetic screens in budding yeast and Drosophila identified several key regulators of mitosis, including the founding member of the Polo kinase family. Since then, a total of five mammalian paralogs of the Drosophila Polo gene have been discovered.
von Schubert, Conrad, Nigg, Erich A.
openaire +5 more sources
Polo-like kinases in AML [PDF]
Expert Opinion on Investigational Drugs, 2012 New therapies targeting critical elements of the cell cycle open novel and attractive avenues for the treatment of cancer patients. At present, the number of clinical trials that are registered with the European Organization for Research and Treatment of Cancer (EORTC) and with the US National Cancer Institute, which investigate the efficacy of Polo ...
Tobias, Berg +3 more
openaire +2 more sources
Polo-like kinases and oncogenesis [PDF]
Oncogene, 2005 Polo-like kinases (Plks) play pivotal roles in the regulation of cell cycle progression. Plk1, the best characterized family member among mammalian Plks, strongly promotes the progression of cells through mitosis. Furthermore, Plk1 is found to be overexpressed in a variety of human tumors and its expression correlates with cellular proliferation and ...
Frank, Eckerdt +2 more
openaire +2 more sources
Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3. [PDF]
Biol Pharm BullAssay systems for evaluating compound protein-binding affinities are essential for developing agonists and/or antagonists. Targeting individual members of a protein family can be extremely important and for this reason it is critical to have methods for evaluating selectivity.
Tsuji K, Tamamura H, Burke TR.
europepmc +3 more sources
Polo-like kinases in the nervous system [PDF]
Oncogene, 2005 Polo like kinases (Plks) are key regulators of the cell cycle, but little is known about their functions in postmitotic cells such as neurons. Recent findings indicate that Plk2 and Plk3 are dynamically regulated in neurons by synaptic activity at the mRNA and protein levels.
Daniel P, Seeburg +2 more
openaire +2 more sources