Results 11 to 20 of about 15,983 (179)
The balance of Polo-like kinase 1 in tumorigenesis [PDF]
Cell Division, 2009 Polo-like kinase 1 (Plk1) belongs to a family of conserved serine/threonine kinases with a polo-box domain, which have similar but non-overlapping functions in the cell cycle progression. Plk1 plays a key role to ensure the normal mitosis. Interestingly,
Yu Xiaochun, Lu Lin-Yu
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Polo-like kinase 1 as target for cancer therapy [PDF]
Experimental Hematology & Oncology, 2012 Polo-like kinase 1 (Plk1) is an interesting molecule both as a biomarker and as a target for highly specific cancer therapy for several reasons. Firstly, it is over-expressed in many cancers and can serve as a biomarker to monitor treatment efficacy of ...
Weiß Lily, Efferth Thomas
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Current Biology, 2013 What is Polo and what are Plks? Plk stands for Polo-like kinase. In the 1980s, genetic screens in budding yeast and Drosophila identified several key regulators of mitosis, including the founding member of the Polo kinase family. Since then, a total of five mammalian paralogs of the Drosophila Polo gene have been discovered.
von Schubert, Conrad, Nigg, Erich A.
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Polo-like kinases and oncogenesis [PDF]
Oncogene, 2005 Polo-like kinases (Plks) play pivotal roles in the regulation of cell cycle progression. Plk1, the best characterized family member among mammalian Plks, strongly promotes the progression of cells through mitosis. Furthermore, Plk1 is found to be overexpressed in a variety of human tumors and its expression correlates with cellular proliferation and ...
Frank, Eckerdt +2 more
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Polo-like kinases in AML [PDF]
Expert Opinion on Investigational Drugs, 2012 New therapies targeting critical elements of the cell cycle open novel and attractive avenues for the treatment of cancer patients. At present, the number of clinical trials that are registered with the European Organization for Research and Treatment of Cancer (EORTC) and with the US National Cancer Institute, which investigate the efficacy of Polo ...
Tobias, Berg +3 more
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Application of a Fluorescence Recovery-Based Polo-Like Kinase 1 Binding Assay to Polo-Like Kinase 2 and Polo-Like Kinase 3. [PDF]
Biol Pharm BullAssay systems for evaluating compound protein-binding affinities are essential for developing agonists and/or antagonists. Targeting individual members of a protein family can be extremely important and for this reason it is critical to have methods for evaluating selectivity.
Tsuji K, Tamamura H, Burke TR.
europepmc +3 more sources
Human Polo-like Kinase Inhibitors as Antiplasmodials. [PDF]
ACS Infect Dis, 2023 Protein kinases have proven to be a very productive class of therapeutic targets, and over 90 inhibitors are currently in clinical use primarily for the treatment of cancer. Repurposing these inhibitors as antimalarials could provide an accelerated path to drug development.
Bohmer MJ +16 more
europepmc +5 more sources
Polo-like kinases in the nervous system [PDF]
Oncogene, 2005 Polo like kinases (Plks) are key regulators of the cell cycle, but little is known about their functions in postmitotic cells such as neurons. Recent findings indicate that Plk2 and Plk3 are dynamically regulated in neurons by synaptic activity at the mRNA and protein levels.
Daniel P, Seeburg +2 more
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The mitotic roles of Polo-like kinase [PDF]
Journal of Cell Science, 2001 The Polo-like protein kinases (Plks) are a conserved family of enzymes that play a variety of roles in the passage of cells through M phase (for reviews see [Glover et al., 1998][1]; [Nigg, 1998][2]).
Donaldson, M. M. +4 more
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Structure and function of Polo-like kinases [PDF]
Oncogene, 2005 Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region that contains one or two Polo-boxes. For Polo-like kinase 1, 2, and 3, and their homologs, the entire C-terminal region, including both Polo-boxes, functions as a ...
Drew M, Lowery +2 more
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