Results 1 to 10 of about 15,933 (134)

Polo-like kinase 1 promotes pulmonary hypertension [PDF]

Respiratory Research, 2023
Background Pulmonary hypertension (PH) is a lethal vascular disease with limited therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not well understood.
Rongrong Chen, Hongfei Wang, Cuiting Zheng, Xiyu Zhang, Li Li, Shengwei Wang, Hongyu Chen, Jing Duan, Xian Zhou, Haiyong Peng, Jing Guo, Anchen Zhang, Feifei Li, Wang Wang, Yu Zhang, Jun Wang, Chen Wang, Yan Meng, Xinling Du, Hongbing Zhang   +19 more
doaj   +2 more sources

Polo-like kinase 1 regulates growth in juvenile Fasciola hepatica. [PDF]

PLoS Pathogens
Fasciola sp. (liver fluke) are parasitic flatworms that impose a significant burden on the agri-food industry and human health. Immature worms can cause severe damage to the liver as they migrate towards the bile ducts, and yet there is only a single ...
Paul McCusker, Nathan G Clarke, Rebecca Armstrong, Duncan Wells, Emily Robb, Paul McVeigh, Andreas Krasky, John Harrington, Paul M Selzer, Nikki J Marks, Aaron G Maule   +10 more
doaj   +2 more sources

Polo-like Kinase 4: A Molecular Culprit in Skin Cancer Pathogenesis [PDF]

Cells
Skin cancer remains a significant global health challenge, with rising incidence and associated mortality in late-stage and drug-resistant cases. This underscores a continuing need for more effective novel therapeutic options that can be utilized for ...
Tanya Jaiswal, Durdana Muntaqua, Nihal Ahmad   +2 more
doaj   +2 more sources

Pan-cancer analysis of polo-like kinase family genes reveals polo-like kinase 1 as a novel oncogene in kidney renal papillary cell carcinoma [PDF]

Heliyon
Background: Polo-like kinases (PLKs) are a kinase class of serine/threonine with five members that play crucial roles in cell cycle regulation. However, their biological functions, regulation, and expression remain unclear.
Guo Zhao, Yuning Wang, Jiawei Zhou, Peiwen Ma, Shuhang Wang, Ning Li   +5 more
doaj   +2 more sources

Synthetic Strategies of Pyrimidine-Based Scaffolds as Aurora Kinase and Polo-like Kinase Inhibitors

Molecules, 2021
The past few decades have witnessed significant progress in anticancer drug discovery. Small molecules containing heterocyclic moieties have attracted considerable interest for designing new antitumor agents. Of these, the pyrimidine ring system is found
Mrunal Jadhav, Kaksha Sankhe, Richie R. Bhandare, Zehra Edis, Samir Haj Bloukh, Tabassum Asif Khan   +5 more
doaj   +1 more source

Polo-like kinase in trypanosomes: an odd member out of the Polo family [PDF]

Open Biology, 2020
Polo-like kinases (Plks) are evolutionarily conserved serine/threonine protein kinases playing crucial roles during multiple stages of mitosis and cytokinesis in yeast and animals.
Yasuhiro Kurasawa, Tai An, Ziyin Li
doaj   +1 more source

Recent Progress in Development of Polo-Like Kinase 1 Inhibitors: Efforts So Far [PDF]

Pharmaceutical Sciences, 2021
Polo-like kinase 1(Plk1) plays an important role in the inhibition of cell proliferation and which is come under the family of serine/threonine-protein kinase. Which is a highly specific target for cancer therapy.
Ramesh L. Sawant, Jyoti B. Wadekar, Rushikesh D. Ukirde, Ganesh D. Barkade   +3 more
doaj   +1 more source

Polo-Like Kinase 2: From Principle to Practice

Frontiers in Oncology, 2022
Polo-like kinase (PLK) 2 is an evolutionarily conserved serine/threonine kinase that shares the n-terminal kinase catalytic domain and the C-terminal Polo Box Domain (PBD) with other members of the PLKs family.
Chuanyong Zhang, Chuanyong Zhang, Chuangye Ni, Chuangye Ni, Hao Lu, Hao Lu   +5 more
doaj   +1 more source

Clinical Significance of Polo-Like Kinase 4 as a Marker for Advanced Tumor Stage and Dismal Prognosis in Patients With Surgical Gastric Cancer

Technology in Cancer Research & Treatment, 2020
Objective: This study aimed to investigate the correlation of polo-like kinase 4 with clinicopathological features and survival profiles in patients with gastric cancer.
Ting Cao MM, Shijie Yi MM, Xuefeng Yang MD, Qing Wu MB   +3 more
doaj   +1 more source

Polo-like kinase 1 as a promising diagnostic biomarker and potential therapeutic target for hepatocellular carcinoma

Tumor Biology, 2020
Hepatocellular carcinoma is a major cause of cancer mortality worldwide. The outcome of hepatocellular carcinoma depends mainly on its early diagnosis. To date, the performance of traditional biomarkers is unsatisfactory.
Eman H. Yousef, Mohamed E El-Mesery, Maha R Habeeb, Laila A Eissa   +3 more
doaj   +1 more source