Results 21 to 30 of about 15,983 (179)
Polo-like kinases (Plks) and cancer [PDF]
Oncogene, 2005 Deregulated centrosome duplication or maturation often results in increased centrosome size and/or centrosome number, both of which show a positive and significant correlation with aneuploidy and chromosomal instability, thus contributing to cancer formation.
Noriyuki, Takai +3 more
openaire +2 more sources
Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer [PDF]
Journal of Pathology and Translational Medicine, 2022 Background Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase located in the centriole of the chromosome during the cell cycle. PLK4 overexpression has been described in a variety of many common human epithelial tumors.
Hyunseung Oh +8 more
doaj +1 more source
Chemical Probe for Imaging of Polo-like Kinase 4 and Centrioles [PDF]
JACS Au, 2023 Aleksandar Salim +6 more
doaj +2 more sources
Haematologica, 2011 Background In advanced systemic mastocytosis the response of neoplastic mast cells to conventional drugs is poor and the prognosis is bad. Current research is, therefore, attempting to identify novel drug targets in neoplastic mast cells.
Barbara Peter +13 more
doaj +1 more source
Polo-like kinase-activating kinases [PDF]
Cell Cycle, 2012 The events of cell division are regulated by a complex interplay between kinases and phosphatases. Cyclin-dependent kinases (Cdks), polo-like kinases (Plks) and Aurora kinases play central roles in this process. Polo kinase (Plk1 in humans) regulates a wide range of events in mitosis and cytokinesis.
Vincent, Archambault, Mar, Carmena
openaire +2 more sources
The CINs of Polo-Like Kinase 1 in Cancer [PDF]
Cancers, 2020 Polo-like kinase 1 (PLK1) is overexpressed near ubiquitously across all cancer types and dysregulation of this enzyme is closely tied to increased chromosomal instability and tumor heterogeneity. PLK1 is a mitotic kinase with a critical role in maintaining chromosomal integrity through its function in processes ranging from the mitotic checkpoint ...
Chelsea E. Cunningham +5 more
openaire +2 more sources
Haematologica, 2013 This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia.
Stefanie A. Hartsink-Segers +8 more
doaj +1 more source
A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia
Parasites & Vectors, 2021 Background Polo-like kinases (PLKs) are conserved serine/threonine kinases that regulate the cell cycle. To date, the role of Giardia lamblia PLK (GlPLK) in cells has not been studied. Here, we report our investigation on the function of GlPLK to provide
Eun-Ah Park +3 more
doaj +1 more source
The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells. [PDF]
PLoS Biology, 2010 The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis.
Conrad von Schubert +5 more
doaj +1 more source
Polo-Like Kinases: A Team in Control of the Division [PDF]
Cell Cycle, 2006 Polo, the founding member of the family of polo-like kinases (Plks) was identified in a Drosophila screen for mutants affecting spindle pole behavior.(1) Several mutants showed defects at their spindle poles and were hence named after the magnetic poles of the earth or geo-magnetic phenomena associated with them, like Polo and Aurora.
Barbara C M, van de Weerdt +1 more
openaire +2 more sources