Results 21 to 30 of about 5,163,498 (211)

The mitotic roles of Polo-like kinase [PDF]

Journal of Cell Science, 2001
The Polo-like protein kinases (Plks) are a conserved family of enzymes that play a variety of roles in the passage of cells through M phase (for reviews see [Glover et al., 1998][1]; [Nigg, 1998][2]).
Donaldson, M. M., Tavares, A. A., Hagan, I. M., Nigg, E. A., Glover, D. M.   +4 more
openaire   +3 more sources

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis [PDF]

, 2003
We have investigated the function of mitotic kinesin-like protein (MKlp) 2, a kinesin localized to the central spindle, and demonstrate that its depletion results in a failure of cleavage furrow ingression and cytokinesis, and disrupts localization of ...
Mayer, Thomas U., Erich A. Nigg, Francis A. Barr, Neef, Rüdiger, Josephine Sutcliffe, Kopajtich, R., Rüdiger Neef, Nigg, E. A., Robert Kopajtich, Mayer, T. U., Thomas U. Mayer, Christian Preisinger, Preisinger, C., Neef, R., Sutcliffe, J., Barr, F. A., Nigg, Erich A., Sutcliffe, Josephine, Kopajtich, Robert, Preisinger, Christian, Barr, Francis A.   +20 more
core   +1 more source

Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer [PDF]

Journal of Pathology and Translational Medicine, 2022
Background Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase located in the centriole of the chromosome during the cell cycle. PLK4 overexpression has been described in a variety of many common human epithelial tumors.
Hyunseung Oh, Soon Gu Kim, Sung Uk Bae, Sang Jun Byun, Shin Kim, Jae-Ho Lee, Ilseon Hwang, Sun Young Kwon, Hye Won Lee   +8 more
doaj   +1 more source

Structure and function of Polo-like kinases [PDF]

Oncogene, 2005
Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region that contains one or two Polo-boxes. For Polo-like kinase 1, 2, and 3, and their homologs, the entire C-terminal region, including both Polo-boxes, functions as a ...
Drew M, Lowery, Daniel, Lim, Michael B, Yaffe   +2 more
openaire   +2 more sources

Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536

Haematologica, 2011
Background In advanced systemic mastocytosis the response of neoplastic mast cells to conventional drugs is poor and the prognosis is bad. Current research is, therefore, attempting to identify novel drug targets in neoplastic mast cells.
Barbara Peter, Karoline V. Gleixner, Sabine Cerny-Reiterer, Harald Herrmann, Viviane Winter, Emir Hadzijusufovic, Veronika Ferenc, Karina Schuch, Irina Mirkina, Hans-Peter Horny, Winfried F. Pickl, Leonhard Müllauer, Michael Willmann, Peter Valent   +13 more
doaj   +1 more source

Polo-like kinases (Plks) and cancer [PDF]

Oncogene, 2005
Deregulated centrosome duplication or maturation often results in increased centrosome size and/or centrosome number, both of which show a positive and significant correlation with aneuploidy and chromosomal instability, thus contributing to cancer formation.
Noriyuki, Takai, Ryoji, Hamanaka, Jun, Yoshimatsu, Isao, Miyakawa   +3 more
openaire   +2 more sources

A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia

Parasites & Vectors, 2021
Background Polo-like kinases (PLKs) are conserved serine/threonine kinases that regulate the cell cycle. To date, the role of Giardia lamblia PLK (GlPLK) in cells has not been studied. Here, we report our investigation on the function of GlPLK to provide
Eun-Ah Park, Juri Kim, Mee Young Shin, Soon-Jung Park   +3 more
doaj   +1 more source

The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells. [PDF]

PLoS Biology, 2010
The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis.
Conrad von Schubert, Gongda Xue, Jacqueline Schmuckli-Maurer, Kerry L Woods, Erich A Nigg, Dirk A E Dobbelaere   +5 more
doaj   +1 more source

Coupling of Polo kinase activation to nuclear localization by a bifunctional NLS is required during mitotic entry

Nature Communications, 2017
Drosophila Polo kinase is the founding member of the Polo-Like Kinase (PLK) family and a master regulator of mitosis and cytokinesis. Here the authors uncover a molecular mechanism for the spatiotemporal regulation of Polo kinase during mitotic entry ...
David Kachaner, Damien Garrido, Haytham Mehsen, Karine Normandin, Hugo Lavoie, Vincent Archambault   +5 more
doaj   +1 more source

An investigation of Plk1 PBD inhibitor KBJK557 as a tumor growth suppressor in non-small cell lung cancer

Journal of Analytical Science and Technology, 2022
Lung cancer is the second most commonly reported type of cancer worldwide. Approximately 80–85% of lung cancer occurrences are accounted by non-small cell lung cancer (NSCLC).
Pethaiah Gunasekaran, Gong-Hyeon Lee, Yeon Sil Hwang, Bon-Chul Koo, Eun Hee Han, Guel Bang, Yeo Kyung La, Sunghyun Park, Hak Nam Kim, Mi-Hyun Kim, Jeong Kyu Bang, Eun Kyoung Ryu   +11 more
doaj   +1 more source