Results 31 to 40 of about 547,441 (316)

Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I [PDF]

, 2010
Mammalian cleavage factor I (CF Im) is composed of two polypeptides of 25 kDa and either a 59 or 68 kDa subunit (CF Im25, CF Im59, CF Im68). It is part of the cleavage and polyadenylation complex responsible for processing the 39 ends of messenger RNA ...
Antje Ostareck-Lederer, Neuenkirchen, N., Ostareck-Lederer, Antje, Keller, W., Dettwiler, Sabine, Sabine Dettwiler, Fischer, Utz, Martin, Georges, Rüegsegger, U., Fischer, U., Georges Martin, Ashwin Chari, Blank, Diana, Diana Blank, Neuenkirchen, Nils, Blank, D., Utz Fischer, Chari, Ashwin, Ostareck-Lederer, A., Nils Neuenkirchen, Walter Keller, Chari, A., Ursula Rüegsegger, Dettwiler, S., Martin, G., Keller, Walter, Rüegsegger, Ursula   +26 more
core   +1 more source

Identification of the Amide II Band in the cis-Amide 1-Methyluracil, in Poly(U), and in Poly(A)·Poly(U)

Journal of Biological Chemistry, 1973
The amide II band, extensively studied in secondary trans-amides but generally reported to be absent in the infrared spectra of cis-amides, has been identified at 1417 cm-1 in the cyclic cis-amide 1-methyluracil. Specific isotopic substitution (2H, 18O, 15N) provides unambiguous evidence that the mode is an N—H bending vibration extensively coupled to ...
H T, Miles, T P, Lewis, E D, Becker, J, Frazier   +3 more
openaire   +2 more sources

On the Different Mode of Action of Au(I)/Ag(I)-NHC Bis-Anthracenyl Complexes Towards Selected Target Biomolecules

Molecules, 2020
Gold and silver N-heterocyclic carbenes (NHCs) are emerging for therapeutic applications. Multiple techniques are here used to unveil the mechanistic details of the binding to different biosubstrates of bis(1-(anthracen-9-ylmethyl)-3-ethylimidazol-2 ...
Francesca Binacchi, Federica Guarra, Damiano Cirri, Tiziano Marzo, Alessandro Pratesi, Luigi Messori, Chiara Gabbiani, Tarita Biver   +7 more
doaj   +1 more source

Two acid RNases from Dactylis glomerata seeds. Purification, properties and effect of polyamines and lectins on their activity

Acta Societatis Botanicorum Poloniae, 2014
Two glycoproteidic acid RNases (RNase I and RNase II) were obtained and purified from the seeds of Dactylis glomerata by extraction with acetate buffer, fractionation with ammonium sulfate, ion-exchange chromatography on DEAE-cellulose, DEAE-Sphadex ...
Janina Wiśniowska, Bronisława Morawiecka   +1 more
doaj   +1 more source

Impact of speciation on the tellurium electrochemistry in choline chloride-based deep eutectic solvents

Electrochemistry Communications, 2022
The electrochemistry of tellurium in two different deep eutectic solvents, choline chloride - urea (ChCl-U) and choline chloride - oxalic acid (ChCl-Ox) was studied on glassy carbon (GC) and polycrystalline (Au(poly)) gold electrodes by cyclic and ...
Alassane Sorgho, Moussa Bougouma, Gael De Leener, Julien Vander Steen, Thomas Doneux   +4 more
doaj   +1 more source

Hempseed Lignanamides Rich-Fraction: Chemical Investigation and Cytotoxicity towards U-87 Glioblastoma Cells

Molecules, 2020
The weak but noteworthy presence of (poly)phenols in hemp seeds has been long overshadowed by the essential polyunsaturated fatty acids and digestible proteins, considered responsible for their high nutritional benefits.
Ersilia Nigro, Giuseppina Crescente, Marialuisa Formato, Maria Tommasina Pecoraro, Marta Mallardo, Simona Piccolella, Aurora Daniele, Severina Pacifico   +7 more
doaj   +1 more source

HCV poly U/UC sequence–induced inflammation leads to metabolic disorders in vulvar lichen sclerosis

Life Science Alliance, 2021
Multi-omics analysis reveals the elevation of HCV poly U/UC sequences, which induces abnormal inflammation and related metabolic disorder in vulvar lichen sclerosis.
Qing Cong, Xiao Guo, Shengwei Zhang, Jinhui Wang, Yi Zhu, Lili Wang, Guangxing Lu, Yufeng Zhang, Wei Fu, Liying Zhou, Shuaikang Wang, Cenxi Liu, Jia Song, Chaoyong Yang, Chi Luo, Ting Ni, Long Sui, He Huang, Jin Li   +18 more
doaj   +1 more source

The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition

, 2008
The degradation of the poly(A) tail is crucial for posttranscriptional gene regulation and for quality control of mRNA. Poly(A)-specific ribonuclease (PARN) is one of the major mammalian 3’ specific exo-ribonucleases involved in the degradation of the ...
Naohiro Kobayashi, Shirouzu, Mikako, Sakura Suzuki, Nagata, Takashi, Yoshihide Hayashizaki, Takashi Nagata, Yutaka Muto, Takanori Kigawa, Kobayashi, Naohiro, Peter Güntert, Mikako Shirouzu, Muto, Yutaka, Akiko Tanaka, Endo, Ryuta, Makoto Inoue, Hayashizaki, Yoshihide, Terada, Takaho, Inoue, Makoto, Kigawa, Takanori, Suzuki, Sakura, Yokoyama, Shigeyuki, Takaho Terada, Ryuta Endo, Shigeyuki Yokoyama, Güntert, Peter, Tanaka, Akiko   +25 more
core   +1 more source

Identification of MYC intron 2 regions that modulate expression.

PLoS ONE
MYC pre-mRNA is spliced with high fidelity to produce the transcription factor known to regulate cellular differentiation, proliferation, apoptosis, and alternative splicing.
Van S Tompkins, Zheng Xue, Jake M Peterson, Warren B Rouse, Collin A O'Leary, Walter N Moss   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source